Keywords: DHEA; dehydroepiandrosterone; DHEAS; dehydroepiandrosterone sulfonate; DMSO; dimethyl sulfoxide; HEK; human embryonic kidney cells; HRP; horseradish peroxidase; PAPS; 3â²-phosphoadenosine 5â²-phosphosulfate; PCR; polymerase chain reaction; PVDF; polyvin
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Keywords: AL; alantolactone; AL-GSH; glutathione conjugate of alantolactone; AL-Cys; cysteine conjugate of alantolactone; AUC; area under the concentration-time curve; Cys; cysteine; CYP450; cytochrome P450; DAD; diode array detector; GSH; glutathione; GST; glutath
Keywords: AUC; area under the concentration-time curve; AST; aspartate transaminase; ALT; alanine transaminase; BCRP; breast cancer resistance protein; BEI; biliary excretion index; CL/F; oral clearance; Clbiliary; in vitro biliary clearance; ER; Efflux Ratio; LCâ
Keywords: Androgens; Intracrinology; Steroid biosynthesis; Hormone-dependent cancer; Testosterone; 11-oxygenated androgens; 11KA4; 11-keto-androstenedione; 11KDHT; 11-keto-5α-dihydrotestosterone; 11KT; 11-keto-testosterone; 11OHA4; 11β-hydroxy-androstenedione; 11
Keywords: Oxysterols; Cancer; Polymorphism; Risk; Genetics; Cholesterol; 25(OH)D; 25-hydroxyvitamin D; ABC; ATP-binding cassette; AEBS; antiestrogen-binding site; BC; breast cancer; BCR; biochemical recurrence; CETP; cholesteryl ester transfer protein; CH25H; chole
Keywords: Cytochrome P450; Liver; Gene expression; Sex; Age; Drug metabolism; BChE; butyrylcholinesterase; CYP; cytochrome P450; GST; glutathione S-transferase; PCR; polymerase chain reaction; PXR; pregnane X receptor; RT-PCR; reverse transcriptase PCR; SULT; sulfo
Keywords: ABCC; ATP-binding cassette sub-family C; ABCG2; ATP-binding cassette sub-family G member 2 (BCRP); DHFA; Dihydroferulic acid; DMCA; 3,4-dimethoxycinnamic acid; FA; Ferulic acid; FA-glu; Ferulic acid-4-O-glucuronide; FA-sul; Ferulic acid-4-O-sulfate; HT; H
Keywords: 2-hydroxy-estradiol; 2,3-dihydroxy-17β-estradiol; 2-methoxy-estradiol; 2-methoxy-3-hydroxy-17β-estradiol; 4-methoxy-estradiol; 3-hydroxy-4-methoxy-17β-estradiol; 4-hydroxy-estradiol; 3,4-dihydroxy-17β-estradiol; 16α-hydroxy-estradiol; 3,16α-dihydrox
Keywords: CYP; cytochrome P450; 3-D; three-dimensional; APAP; acetaminophen; NAPQI; N-acetyl-p-benzoquinone imine; GSH; glutathione; ROS; reactive oxygen species; UGT; UDP-glucuronosyltransferase; SULT; sulfotransferase; ABT; 1-aminobenzotriazole; mBCl; monochlorob
Keywords: SULT, cytosolic sulfotransferase; PAPS, 3′-phosphoadenosine-5′-phosphosulfate; TLC, thin-layer chromatographyCytosolic sulfotransferase; SULT; Sulfation; Opioids; Drugs
Keywords: AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; BT; β-tubulin; CYP; cytochrome P450 monooxygenase enzymes; EF; elongation factor; GAPDH; glyceraldehyde 3-phosphate dehudrogenase; GR; glucocorticoid receptor; HSP; hea
Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1
Keywords: DHEA; dehydroepiandrosterone; DHEAS; dehydroepiandrosterone sulfate; OH-PCB; hydroxylated polychlorinated biphenyl; 4â²-OH PCB 3; 4-chloro-4â²-hydroxybiphenyl; 4-OH-PCB 8; 2,4â²-dichloro-4-hydroxybiphenyl; 4-OH-PCB 11; 3,3â²-dichloro-4-hydroxybiphenyl
Sulfotransferase-catalyzed biotransformation of liguzinediol and comparison of its metabolism in different species using UFLC-QTOF-MS
Keywords: LZDO; liguzinediol; Cys; cysteine; NAC; N-acetylcysteine; GSH; glutathione; 2-NAC-LZDO; 2-N-acetylcysteine-LZDO; 2-Cys-LZDO; 2-cysteine-LZDO; 2-GSH-LZDO; 2-glutathione-LZDO; HLC; human liver cytosol; HLM; human liver microsomes; RLC; rat liver cytosol; RL
Disruption of thyroid hormone sulfotransferase activity by brominated flame retardant chemicals in the human choriocarcinoma placenta cell line, BeWo
Keywords: Flame Retardants; Thyroid hormones; Sulfotransferase; BeWO; Cell cultures; 2,4,6-TBP; 2,4,6-tribromophenol; DI; deiodinase; DIO3; type 3 deiodinase; GC/MS; gas chromatography/mass spectrometry; IC50; half-maximal inhibitory concentration; Km; Michaelis co
In vitro percutaneous absorption and metabolism of Bisphenol A (BPA) through fresh human skin
Keywords: BPA; Bisphenol A; BPA-gluc; BPA-glucuronide; BPA-sulf; BPA-sulfate; ECHA; European Chemicals Agency; CoRAP; substance evaluation process by ECHA; EFSA; European Food Safety Authority; EPA; U.S. Environmental Protection Agency; OECD TG; Organisation for Ec
Significance of A-to-I RNA editing of transcripts modulating pharmacokinetics and pharmacodynamics
Keywords: ABC; ATP-binding cassette transporter; ADAR; adenosine deaminase acting on RNA; ADH; alcohol dehydrogenase; AhR; aryl hydrocarbon receptor; AKR; aldo-keto reductase; ALS; amyotrophic lateral sclerosis; AZIN1; antizyme inhibitor 1; AMPA; α-amino-3-hydroxy
The body burden and thyroid disruption in lizards (Eremias argus) living in benzoylurea pesticides-contaminated soil
Keywords: BPUs; benzoylurea pesticides; HPT; hypothalamus-pituitary-thyroid; trα; thyroid hormone receptor α; trβ; thyroid hormone receptor β; dio1; deiodinase type 1; dio2; deiodinase type 2; udp; uridine diphosphate glucuronosyl transferase; sult; sulfotransf
Occurrence of sulfonated steroids and ovarian expression of steroid sulfatase and SULT1E1 in cyclic cows
Keywords: A4; androstenedione; AnDiolS; 5-androstene-3β,17β-diol sulfate; An; androsterone; AnS; androsterone sulfate; APCI; atmospheric pressure chemical ionization; CholS; cholesterol sulfate; CL; corpus luteum; COCs; cumulus-oocyte-complexes; DHEA; dehydroepia
A study of inter-individual variability in the Phase II metabolism of xenobiotics in human skin
Keywords: ACD; Allergic contact dermatitis; COMT; catechol-O-methyl transferases; GST; glutathione-S-transferases; HaCaT; Immortalised keratinocytes “Human Adult Low Calcium High Temperature”; NAT; N-acetyltransferases; NHEK; Normal Human Epidermal Keratinocyte
The role of Nrf2-Keap1 signaling pathway in the antioxidant defense response induced by PAHs in the calm Ruditapes philippinarum
Keywords: Polycyclic aromatic hydrocarbons; Ruditapes philippinarum; NF-E2-related nuclear factor 2 (Nrf2); RNAi; R. philippinarum; Ruditapes philippinarum; Nrf2; NF-E2-Related Factor 2; Keap1; Kelch-like-ECH-associated Protein 1; PAHs; Polycyclic Aromatic Hydrocar
Effects of sulfur-fumigation on the pharmacokinetics, metabolites and analgesic activity of Radix Paeoniae Alba
Keywords: AUC; area under the plasma concentration-time curve; BS; Radix Paeoniae Alba; CID; collision-induced dissociation; CL; clearance; Cmax; maximum plasma concentration; FDA; US Food and Drug Administration; HPLC/UV; high performance liquid chromatography/u
Sulfation disposition of liquiritigenin in SULT1A3 overexpressing HEK293 cells: The role of breast cancer resistance protein (BCRP) and multidrug resistance-associated protein 4 (MRP4) in sulfate efflux of liquiritigenin
Keywords: CLint; intrinsic clearance; CYP; cytochrome P450; HPLC; high performance liquid chromatography; Km; Michaelis-Menten constant; MS; mass spectroscopy; PAPS; 3â²-Phosphoadenosine-5â²-phosphosulfate; QTOF; Quadrupole time-of-flight; shRNA; short hairpin RN
Galangin's potential as a functional food ingredient
Keywords: Galangin; Propolis; Alpinia officinarum; Functional food ingredient; Polypharmacology; Flavonoid; AChE; acetylcholinesterase; AD; Alzheimer's disease; ADME; Administration, Distribution, Metabolism and Excretion; AHR; airway hyperresponsive; AhR; aryl h
Original articleOn the sulfation of O-desmethyltramadol by human cytosolic sulfotransferases
Keywords: ATP; adenosine 5â²-triphosphate; O-DMT; O-desmethyltramadol; PAPS; 3â²-phosphoadenosine-5â²-phosphosulfate; SULT; cytosolic sulfotransferase; TLC; thin-layer chromatography; Tramadol; O-Desmethyltramadol; Sulfation; Cytosolic sulfotransferase; Sult;
Identification of a sulfate metabolite of PCB 11 in human serum
Keywords: DCM; dichloromethane; DEE; diethyl ether; Hx; hexane; KCl; potassium chloride; LC-PCB; lower-chlorinated PCB; MRM; multiple reaction monitoring; MTBE; methyl-tert-butyl ether; OH-PCB; hydroxylated PCB; PCB; polychlorinated biphenyl; SULT; cytosolic sulfot
The liver transcriptome of suckermouth armoured catfish (Pterygoplichthys anisitsi, Loricariidae): Identification of expansions in defensome gene families
Keywords: RNA-Seq; P450; SULT; ABC transporters; Nuclear receptors;
Simultaneous quantification of estrogens, their precursors and conjugated metabolites in human breast cancer cells by LC-HRMS without derivatization
Keywords: 3β-HSD; 3β-hydroxysteroiddehydrogenase; 17β-HSD; 17β-hydroxysteroiddehydrogenase; AD; androstenedione; DHEA; dehydroepiandrosterone; DHEA-S; dehydroepiandrosterone-3-sulfate; DMEM; Dulbecco's Modified Eagle Medium F-12; DMSO; dimethylsulfoxide; DPBS;
Cellular adaptation to xenobiotics: Interplay between xenosensors, reactive oxygen species and FOXO transcription factors
Keywords: AhR; arylhydrocarbon receptor; AIP; AhR interacting protein; ARE; antioxidant response element; ARNT; AhR nuclear translocator; bHLH; basic helix-loop-helix (DNA binding and dimerisation domain); CAR; constitutive androstane receptor; CBP; CREB-binding pr
Î4-3-ketosteroids as a new class of substrates for the cytosolic sulfotransferases
Keywords: SULT; Cytosolic sulfotransferase; PAPS; 3â²-phosphoadenosine 5â²-phosphosulfate; DHEA; dehydroepiandrosterone; KSI; Ketosteroid isomerase; Sulfotransferase; Ketosteroid; 4-androstene-3,17-dione; Ketosteroid isomerase;
The translocator protein (18Â kDa) and its role in neuropsychiatric disorders
Keywords: 3α-HSD; 3α-hydroxysteroid dehydrogenase; 3β-HSD; 3β-hydroxysteroid dehydrogenase/Î5âÎ4; AIF; apoptosis inducing factor; AD; Alzheimer's disease; ANT; adenine nucleotide translocator; AP-1; activator protein 1; APAF-1; apoptotic peptidase activat
Human cytosolic sulfotransferase SULT1C4 mediates the sulfation of doxorubicin and epirubicin
Keywords: Doxorubicin; Epirubicin; Sulfation; Cytosolic sulfotransferase; SULT; ATP; adenosine 5â²-triphosphate; PAPS; 3â²-phosphoadenosine 5â²-phosphosulfate; SULT; cytosolic sulfotransferase;
Function and organization of the human cytosolic sulfotransferase (SULT) family
Keywords: Sulfotransferase; Sulfation; Detoxification; Liver; Metabolism; SULT; sulfotransferase; PAPS; 3â²-phosphoadenosine 5â²-phosphosulfate; DHEA; dehydroepiandrosterone; DHEAS; dehydroepiandrosterone sulfate; APS; adenosine 5â²-phosphosulfate;
Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues
Keywords: 2,4,6-TBP; 2,4,6-tribromophenol; BFR; brominated flame retardant; DI; deiodinase; GC/ECNI-MS; electron capture negative ion mass spectrometry; HIPS; high-impact polystyrene; LC-MS/MS; liquid chromatography tandem mass spectrometry; PBDE; polybrominated
MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes
Keywords: CYP; cytochrome P450; miRNA; microRNA; DMETs; drug metabolizing enzymes and transporters; CAR; constitutive androstane receptor; PXR; pregnane X receptor; RE; response element; 3â²-UTR; 3â²-untranslated region; SULT; sulfotransferase; Ago; argonaute RIS
Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver
Keywords: ALF; acute liver failure; NAPQI; N-acetyl-p-benzoquinone imine; UGT; UDP-glucuronosyltransferase; SULT; sulfotransferase; CYP; cytochrome P450; 3â²-UTR; 3â²-untranslated region; SNP; single nucleotide polymorphism; miRNA; microRNA; UDPGA; uridine diphos
An engineered heterodimeric model to investigate SULT1B1 dependence on intersubunit communication
Keywords: PAP; 3â²,5â²-diphosphoadenosine; PAPS; 3â²-phosphoadenosine 5â²-phosphosulfate; SULT; cytosolic sulfotransferase; Drug metabolism; Sulfation; Protein engineering; Half-site reactivity; SULT1B1;
Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1â²-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism
Keywords: CYP; cytochrome P450s; DEX; dexamethasone; E-3â²-N2-dGuo; N2-(trans-isoestragol-3â²-yl)-2â²-deoxyguanosine; GSTs; glutathione S transferases; OTM; olive tail moment; PAPSS; 3â²-phosphoadenosine 5â²-phosphosulphate synthase; PCP; pentachlorophenol; PN
MicroRNAs related to androgen metabolism and polycystic ovary syndrome
Keywords: Polycystic ovary syndrome; MicroRNA; Androgens; DHEA; DHEAS; Ovarian steroid metabolism; Biomarker; DHEA; dehydroepiandrosterone; DHEAS; dehydroepiandrosterone sulfate; PCOS; polycystic ovary syndrome; T2D; type 2 diabetes mellitus; CYP; Cytochrome P450;
Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes
Keywords: ABC; ATP-binding cassette transporter; AGPAT2; 1-acylglycerol-3-phosphate O-acyltransferase; AhR; arylhydrocarbon receptor; AKR1C1; aldo-keto reductase 1C1; APO; apolipoprotein; ASBT; apical sodium dependent bile acid transporter; BAs; bile acids; BSEP; b
Oxysterols: From cholesterol metabolites to key mediators
Keywords: ABC; ATP-binding cassette; ACAT; acyl-coenzyme A cholesterol acyltransferase; C4; 7-hydroxycholestenone; CA; cholestanoic acid; CH25H; cholesterol-25-hydroxylase; ChEH; cholesterol epoxide hydrolase; CNS; central nervous system; CSF; cerebrospinal fluid;
Bisphenol A and its analogs: Do their metabolites have endocrine activity?
Keywords: BPA; bisphenol A (4,4â²-(propane-2,2-diyl)diphenol); BPAF; bisphenol AF (1,1,1,3,3,3-hexafluoro-2,2-bis (4-hydroxyphenyl)propane); BPB; bisphenol B, (2,2-bis(4-hydroxyphenyl)butane); BPF; bisphenol F (bis(4-hydroxyphenyl)methane); BPS; bisphenol S (bis[4
Sulfation of ritodrine by the human cytosolic sulfotransferases (SULTs): Effects of SULT1A3 genetic polymorphism
Keywords: SULT; cytosolic sulfotransferase; PAPS; 3â²-phosphoadenosine-5â²-phosphosulfate; PCR; polymerase chain reaction; SNP; single nucleotide polymorphism.; Sulfation; Ritodrine; Cytosolic sulfotransferase; SULT; SULT1A3; Genetic polymorphism;
Structural plasticity in the human cytosolic sulfotransferase dimer and its role in substrate selectivity and catalysis
Keywords: SULT; Cytosolic sulfotransferase; Sulfation; PAPS; 3′-phosphoadenosine-5′-phosphosulfate; PAP; 3′-diphosphoadenosine; Structure; Metabolism
Hepatic expression patterns of aryl hydrocarbon receptor, pregnane X receptor, two cytochrome P450s and five phase II metabolism genes responsive to 17alpha-methyltestosterone in rare minnow Gobiocypris rarus
Keywords: AHR; aryl hydrocarbon receptor; PXR; pregnane X receptor; CYP; cytochrome P450; SULT; sulfotransferase; UGT; UDP-glucuronosyltransferases; AHR2; PXR; Cytochrome P450; Sulfotransferase; UDP-glucuronosyltransferases; 17Alpha-methyltestosterone;
Malabaricone C-containing mace extract inhibits safrole bioactivation and DNA adduct formation both in vitro and in vivo
Keywords: BMD; benchmark dose; BMDL10; the lower confidence limit of the benchmark dose causing 10% extra tumor incidence; EDI; estimated daily intake; GSH; glutathione reduced; 7HC; 7-hydroxycoumarin; 7HCS; 7-hydroxycoumarin sulfate; HPLC; high performance liquid
Coupling ultra-high-pressure liquid chromatography with mass spectrometry for in-vitro drug-metabolism studies
Keywords: ADC; Analog-to-digital converter; ADMET; Absorption, distribution, metabolism, excretion and toxicity; APCI; Atmospheric pressure chemical ionization; CYP; Cytochrome P450; DDI; Drug-drug interaction; DMPK; Drug metabolism and pharmacokinetics; DT; Dwell
Consequences of psychophysiological stress on cytochrome P450-catalyzed drug metabolism
Keywords: CYP; Cytochrome P450; PAH; polycyclic aromatic hydrocarbon; EROD; ethoxyresorufin 7-dealkylase; PROD; pentoxyresorufin 7-dealkylase; B[α]P; benzo[α]pyrene; PNP; p-nitrophenol hydroxylation; FMO; flavin-containing monoxygenases; EH; epoxide hydrolases; G
Rutaecarpine effects on expression of hepatic phase-1, phase-2 metabolism and transporter genes as a basis of herb-drug interactions
Keywords: Cyp; cytochrome P450; Ugt; glucuronylotransferase; Sult; sulfotransferase; Oatp; organic anion transporting peptide; Mrp; multidrug resistance-associated protein; Rut; rutaecarpine; Rutaecarpine; Herb-drug interaction; Cytochrome P450; Glucuronidation;
Identification and characterization of a novel kaempferol sulfotransferase from Arabidopsis thaliana
Keywords: SULT; cytosolic sulfotransferase; PAPS; 3â²-phosphoadenosine 5â²-phosphosulfate; Sulfotransferase; Flavonoid; Arabidopsis thaliana;
Genetic Variability in 8q24 Confers Susceptibility to Urothelial Carcinoma of the Upper Urinary Tract and is Linked With Patterns of Disease Aggressiveness at Diagnosis
Keywords: urinary tract; urothelium; carcinoma; polymorphism; genetic; genetic predisposition to disease; PCR; polymerase chain reaction; SNP; single nucleotide polymorphism; SULT; sulfotransferase; UC; urothelial carcinoma; UUT; upper urinary tract;