کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8546065 | 1561686 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1
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کلمات کلیدی
PCBDHEASULT2A1SULT1E1OH-PCBdehydroepiandrosteroneSULTDHEASPAPs - PAP هاadenosine 3′-phosphate 5′-phosphosulfate - آدنوزین 3'-فسفات 5'-فسفسفولاتEndocrine disruption - اختلالات غدد درون ریزEstradiol - استرادیولPolychlorinated biphenyl - بیفنیل پلی کربناتPolychlorinated biphenyls - بیفنیل پلیکلر Hydroxylated polychlorinated biphenyls - دیفنیلهای پلی کربنات هیدرولیکی شدهdehydroepiandrosterone sulfate - سولفات dehydroepiandrosteronesulfotransferase - سولفوترانسفرازhydroxylated polychlorinated biphenyl - هیدروکسید پلی فنل بفنیل
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants that are associated with varied adverse health effects. Lower chlorinated PCBs are prevalent in indoor and outdoor air and can be metabolized to their hydroxylated derivatives (OH-PCBs) followed by sulfation to form PCB sulfates. Sulfation is also a means of signal termination for steroid hormones. The human estrogen sulfotransferase (SULT1E1) and alcohol/hydroxysteroid sulfotransferase (SULT2A1) catalyze the formation of steroid sulfates that are inactive at steroid hormone receptors. We investigated the inhibition of SULT1E1 (IC50s ranging from 7.2â¯nM to greater than 10â¯Î¼M) and SULT2A1 (IC50s from 1.3â¯Î¼M to over 100â¯Î¼M) by five lower-chlorinated OH-PCBs and their corresponding PCB sulfates relevant to airborne PCB-exposure. Several congeners of lower chlorinated OH-PCBs relevant to airborne PCB exposures were potent inhibitors of SULT1E1 and SULT2A1 and thus have the potential to disrupt regulation of intracellular concentrations of the receptor-active steroid substrates for these enzymes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 58, March 2018, Pages 196-201
Journal: Environmental Toxicology and Pharmacology - Volume 58, March 2018, Pages 196-201
نویسندگان
Victoria S. Parker, Edwin J. Squirewell, Hans-Joachim Lehmler, Larry W. Robertson, Michael W. Duffel,