کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5561294 1562121 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Classification schemes for carcinogenicity based on hazard-identification have become outmoded and serve neither science nor society
ترجمه فارسی عنوان
طرح های طبقه بندی برای سرطان زایی بر اساس شناسایی خطر قدیمی شده اند و نه به علم و نه به جامعه خدمت می کنند
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- Cancer classification on hazard-identification such as IARC and UN GHS are outmoded.
- Chemicals with differences in potency and modes of action placed in same category.
- Unintended consequences: health scares, costs, and diversion of public funds.
- Modern approaches based on hazard and risk characterization should be used.
- International initiative needed a consensus on for carcinogenicity.

Classification schemes for carcinogenicity based solely on hazard-identification such as the IARC monograph process and the UN system adopted in the EU have become outmoded. They are based on a concept developed in the 1970s that chemicals could be divided into two classes: carcinogens and non-carcinogens. Categorization in this way places into the same category chemicals and agents with widely differing potencies and modes of action. This is how eating processed meat can fall into the same category as sulfur mustard gas. Approaches based on hazard and risk characterization present an integrated and balanced picture of hazard, dose response and exposure and allow informed risk management decisions to be taken. Because a risk-based decision framework fully considers hazard in the context of dose, potency, and exposure the unintended downsides of a hazard only approach are avoided, e.g., health scares, unnecessary economic costs, loss of beneficial products, adoption of strategies with greater health costs, and the diversion of public funds into unnecessary research. An initiative to agree upon a standardized, internationally acceptable methodology for carcinogen assessment is needed now. The approach should incorporate principles and concepts of existing international consensus-based frameworks including the WHO IPCS mode of action framework.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 82, December 2016, Pages 158-166
نویسندگان
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