دانلود مقالات ISI درباره دستورالعمل آزمون + ترجمه فارسی

ارزیابی روش غلظت ثابت برای ارزیابی سمیت بودن استنشاق حاد

An evaluation of the fixed concentration procedure for assessment of acute inhalation toxicity

Keywords: دستورالعمل آزمون; Acute inhalation studies; 3Rs; Evident toxicity; Fixed concentration procedure (FCP); Refinement; Regulatory toxicology; TG403; TG436; TG433; ATC; acute toxic class; CI; confidence interval; FCP; fixed concentration procedure; GHS; globally harmonised sys

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

روش پیش بینی مبتنی بر مسیر برای ارزیابی غیر حیوانات از سمیت استنشاق حاد

Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity

Keywords: دستورالعمل آزمون; Acute inhalation toxicity; In vitro; In silico; Ex vivo; Quantitative structure-activity relationships (QSAR); Adverse outcome pathway; Aggregate exposure pathway; Dosimetry; Integrated approach to testing and assessment (IATA); Risk assessment; ADME; abs

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2018 سفارش ترجمه

فوری برای بهینه سازی و هماهنگی تجزیه و تحلیل هورمون های تیروئید و تفسیر آنها در مطالعات سم شناسی توسعه و تولید مثل

The urgency for optimization and harmonization of thyroid hormone analyses and their interpretation in developmental and reproductive toxicology studies

Keywords: دستورالعمل آزمون; ANSES; Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (French Agency for Food, Environmental and Occupational Health & Safety); CRO; contract research organization; CV; coefficient of variation; DART; deve

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2018 سفارش ترجمه

پذیرش مقررات و استفاده از مطالعات سم شناسی باروری یک نسل در اروپا

Regulatory acceptance and use of the Extended One Generation Reproductive Toxicity Study within Europe

Keywords: دستورالعمل آزمون; ACSA; Agricultural Chemical Safety Assessment of the ILSI HESI; ARA; Actual Regulatory Acceptance by regulatory authorities; CARACAL; Competent Authorities for REACH and GLP; CLP; classification and labelling process; CMR; Carcinogenic, Mutagenic and Repr

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

انتقال قابل توجهی از سوکسواتریت 4 هفته ای سمیت خوراکی به مطالعه تحلیلی نشان داده شده است که نشان دهنده دو داروی ضد درد دارویی و دو آلاینده محیطی با خواص ایمنی

The transferability from rat subacute 4-week oral toxicity study to translational research exemplified by two pharmaceutical immunosuppressants and two environmental pollutants with immunomodulating properties

Keywords: دستورالعمل آزمون; AH-receptor; aryl hydrocarbon receptor; AZA; azathioprine; BaP; benzo[a]pyrene; BN; Brown Norway (rat strain); BfR; Federal Institute for Risk Assessment; BgVV; Federal Institute for Health Protection of Consumers and Veterinary Medicine; BW; body weight;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه

SkinEthic™ HCE Eye Irritation Test: Similar performance demonstrated after long distance shipment and extended storage conditions

Keywords: دستورالعمل آزمون; BLR; Between Laboratory Reproducibility; CAS RN; Chemical Abstracts Service Registry Number; Cat 1; UN GHS classification for chemicals causing irreversible effects on the eye/serious damage to the eye; Cat 2; UN GHS classification for chemicals causing r

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2019 سفارش ترجمه

Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing

Keywords: دستورالعمل آزمون; Mutation; Germ cell; Transgene; Test guideline; Rodent;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

CON4EI: Development of serious eye damage and eye irritation testing strategies with respect to the requirements of the UN GHS/EU CLP hazard categories

Keywords: دستورالعمل آزمون; BCOP; Bovine Corneal Opacity and Permeability; CON4EI; CONsortium for in vitro Eye Irritation testing strategy; EpiOcular™ EIT; EpiOcular Eye Irritation Test; EpiOcular™ ET-50; EpiOcular Time-to-toxicity; EU CLP; European Union Regulation on Classific

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2018 سفارش ترجمه

Simulation of mouse and rat spermatogenesis to inform genotoxicity testing using OECD test guideline 488

Keywords: دستورالعمل آزمون; Mutations; Germ cells; Transgene; Test guideline; Rodent;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

Pre-validation of an in vitro skin irritation test for medical devices using the reconstructed human tissue model EpiDerm™

Keywords: دستورالعمل آزمون; DPBS; Dulbecco's phosphate buffered saline; EPI-200-SIT-MD; EpiDerm skin irritation test for medical devices; ET50; time required to reduce viability to 50%; HA; heptanoic acid; IC 50; inhibition concentration that to reduce viability to 50%; ISO; the Int

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

CON4EI: SkinEthic™ Human Corneal Epithelium Eye Irritation Test (SkinEthic™ HCE EIT) for hazard identification and labelling of eye irritating chemicals

Keywords: دستورالعمل آزمون; BCOP; Bovine Corneal Opacity and Permeability; BCOP LLBO; Bovine Corneal Opacity and Permeability Laser Light based Opacitometer; CAS RN; Chemical Abstracts Service Registry Number; Cat1; UN GHS classification for chemicals causing irreversible effects on

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

CON4EI: Short Time Exposure (STE) test method for hazard identification and labelling of eye irritating chemicals

Keywords: دستورالعمل آزمون; Cat 1; UN GHS classification for chemicals causing irreversible effects on the eye/serious damage to the eye; Cat 2; UN GHS classification for chemicals causing reversible effects on the eye/eye irritation, sub-catagorised in 2A (irritant to eyes, eye eff

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

CON4EI: Slug Mucosal Irritation (SMI) test method for hazard identification and labelling of serious eye damaging and eye irritating chemicals

Keywords: دستورالعمل آزمون; BAC; benzalkonium chloride; Cat 1; UN GHS classification for chemicals causing irreversible effects on the eye/serious damage to the eye; Cat 2; UN GHS classification for chemicals causing reversible effects on the eye/eye irritation, sub-categorized in 2

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

A way forward of alternative methods in China: Implementation of skin corrosivity potential using in vitro reconstructed human epidermis

Keywords: دستورالعمل آزمون; CASRN; Chemical Abstract Service Registry Number; d-PBS; Dulbecco's Phosphate Buffered Saline; EURL ECVAM; European Union Reference Laboratory for European Centre for the Validation of Alternative Methods; GHS; Globally harmonized system of classification

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

CON4EI: EpiOcular™ Eye Irritation Test (EpiOcular™ EIT) for hazard identification and labelling of eye irritating chemicals

Keywords: دستورالعمل آزمون; DBALM; Database of Alternative Methods at the European Commission's Joint Research Centre; Cat 1; UN GHS/EU CLP classification for chemicals causing irreversible effects on the eye/serious damage to the eye; Cat 2; UN GHS/EU CLP classification for chemica

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2018 سفارش ترجمه

CON4EI: CONsortium for in vitro Eye Irritation testing strategy - EpiOcular™ time-to-toxicity (EpiOcular ET-50) protocols for hazard identification and labelling of eye irritating chemicals

Keywords: دستورالعمل آزمون; DBALM; Database of Alternative Methods at the European Commission's Joint Research Centre; Cat 1; UN GHS/EU CLP classification for chemicals causing irreversible effects on the eye/serious damage to the eye; Cat 2; UN GHS/EU CLP classification for chemica

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2018 سفارش ترجمه

CON4EI: Development of testing strategies for hazard identification and labelling for serious eye damage and eye irritation of chemicals

Keywords: دستورالعمل آزمون; BCOP; bovine corneal opacity and permeability; BCOP LLBO; bovine corneal opacity and permeability laser light-based opacitometer; CAS RN; chemical abstracts service registry number; Cat 1; UN GHS classification for chemicals causing irreversible effects o

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

Finding synergies for 3Rs - Toxicokinetics and read-across: Report from an EPAA partners' Forum

Keywords: دستورالعمل آزمون; Physiologically-based kinetic (PBK) modelling; Hazard and risk assessment; Weight-of-evidence (WoE); Threshold of toxicological concern (TTC); In vitro to in vivo extrapolation (IVIVE); Integrated approach for testing and assessment (IATA); Absorption; Di

دانلود رایگان متن کامل مقاله ISI 68 صفحه سال انتشار : 2018 سفارش ترجمه

The challenge of the application of 'omics technologies in chemicals risk assessment: Background and outlook

Keywords: دستورالعمل آزمون; Omics; Transcriptomics; Weight-of-evidence; Registration, Evaluation, Authorisation, and Restriction (REACH); Plant protection products; Regulatory toxicology; Hazard assessment; Test method validation; Test method standardisation; AOP; Adverse outcome pa

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Biometrical evaluation of the performance of the revised OECD Test Guideline 402 for assessing acute dermal toxicity

Keywords: دستورالعمل آزمون; Test guideline; Acute dermal toxicity; Globally Harmonized System (GHS); Biometric evaluation; Animal welfare; ATC; Acute Toxic Class method; FDP; Fixed Dose Procedure; GHS; Globally Harmonized System for Classification and Labelling; LD50; Lethal Dose, 5

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Lacking applicability of in vitro eye irritation methods to identify seriously eye irritating agrochemical formulations: Results of bovine cornea opacity and permeability assay, isolated chicken eye test and the EpiOcular™ ET-50 method to classify acco

Keywords: دستورالعمل آزمون; Serious eye damage; EpiOcular ET-50; Isolated chicken eye test; (Modified) bovine corneal opacity and permeability test; Agrochemical formulation; Classification; AAALAC; Association for Assessment and Accreditation of Laboratory Animal Care; BCOP; bovine

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Evaluation of fibrin-based dermal-epidermal organotypic cultures for in vitro skin corrosion and irritation testing of chemicals according to OECD TG 431 and 439

Keywords: دستورالعمل آزمون; RhE; reconstructed human epidermis; ORG; organotypic skin culture; H&E; hematoxylin and eosin; MTT; 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; BD CBA; Becton Dickinson Cytometric Bead Array; OD; optical density; RH; relative humidity; R

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Guidance on the selection of cohorts for the extended one-generation reproduction toxicity study (OECD test guideline 443)

Keywords: دستورالعمل آزمون; Cohorts; EOGRTS; Extended one-generation reproductive toxicity study; Developmental toxicity; Fertility; Rat; Reproduction; Triggers; ACSA; Agricultural Chemical Safety Assessment; DIT; developmental immunotoxicity; DNT; developmental neurotoxicity; ECETO

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Analysis of the Local Lymph Node Assay (LLNA) variability for assessing the prediction of skin sensitisation potential and potency of chemicals with non-animal approaches

Keywords: دستورالعمل آزمون; ACE; acetone; AOO; acetone:olive oil (4:1 by volume); DMF; dimethylformamide; EC3; effective concentration inducing a stimulation index of 3; ETOH/DEP; Ethanol/diethylphthalate; EXT; extreme (ECETOC classification); IDR; Insufficient Dose Response; MOD; m

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Assessment of cosmetic ingredients in the in vitro reconstructed human epidermis test method EpiSkin™ using HPLC/UPLC-spectrophotometry in the MTT-reduction assay

Keywords: دستورالعمل آزمون; CAS RN; Chemical Abstract Service Registry Number; R2; coefficient of determination; Cat. 1; Category 1; Cat. 2; Category 2; EIT; eye irritation test; DG SANCO; European Commission Directorate General for Health and Consumer Protection; EURL ECVAM; Europe

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

A retrospective evaluation method for in vitro mammalian genotoxicity tests using cytotoxicity index transformation formulae

Keywords: دستورالعمل آزمون; CA; chromosomal aberration; DB; database; ECVAM; The European Centre for the Validation of Alternative Methods; IWGT; International Workshops on Genotoxicity Testing; JEC; Japan Existing Chemical; LOGEL; lowest observed genotoxicity effect level; MN; micr

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2016 سفارش ترجمه

Comparison of the influence of citric acid and acetic acid as simulant for acidic food on the release of alloy constituents from stainless steel AISI 201

Keywords: دستورالعمل آزمون; Austenitic stainless steel; Food contact; CoE protocol; Test guideline; Complexation; Metal release; Surface oxide;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

A decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping)

Keywords: دستورالعمل آزمون; AOP; adverse outcome pathway; APPIE; Association of Powder Process Industry; ASTM; American Society for Testing and Materials; ATP; adenosine triphosphate; BAM; German Federal Institute for Materials Research and Testing; BAuA; German Federal Institute fo

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2015 سفارش ترجمه

In vitro and in vivo genotoxicity investigations of differently sized amorphous SiO2 nanomaterials

Keywords: دستورالعمل آزمون; AAN; average agglomeration number; AUC; analytical ultracentrifugation; BALF; bronchoalveolar fluid; BW; body weight; CFA; colony forming ability; CPH; centrophenoxine; DLS; dynamic light scattering; DMEM; Dulbecco's Modified Eagle Medium; EMS; ethyl me

دانلود رایگان متن کامل مقاله ISI 64 صفحه سال انتشار : 2015 سفارش ترجمه

The OECD expert meeting on ecotoxicology and environmental fate - Towards the development of improved OECD guidelines for the testing of nanomaterials

Keywords: دستورالعمل آزمون; BAF; bioaccumulation factor; BCF; bioconcentration factor; GD; guidance document; EDX; energy dispersive X-ray spectroscopy; FFF; field-flow fractionation; GSPD; Guidance on Sample Preparation and Dosimetry, NM, nanomaterial; OECD; Organisation of Economi

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

CommentaryAssessment of reproductive toxicity under REACH

Keywords: دستورالعمل آزمون; ECHA; European Chemicals Agency; GT; German Society of Toxicology; OECD; Organisation of Economic Cooperation and Development; REACH-EU; Regulation on the Registration, Evaluation, Authorisation and Restriction of Chemicals; TG; test guideline; Test str

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Development of an embryo toxicity test with the pond snail Lymnaea stagnalis using the model substance tributyltin and common solvents

Keywords: دستورالعمل آزمون; Mollusc; Early life stages; Organotin; Pulmonate; Embryonic growth; Test guideline

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Guiding principles for the implementation of non-animal safety assessment approaches for cosmetics: Skin sensitisation

Keywords: دستورالعمل آزمون; ACD; allergic contact dermatitis; AEL; acceptable exposure level; APC; antigen presenting cells; CEL; consumer exposure level; CIR; cosmetic ingredient review; COLIPA; the European Cosmetics Association; DC; dendritic cells; DPRA; direct peptide reactivit

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Combined retrospective analysis of 498 rat multi-generation reproductive toxicity studies: On the impact of parameters related to F1 mating and F2 offspring

Keywords: دستورالعمل آزمون; Multigeneration reproductive toxicity; Test guideline; Database; Developmental toxicity; Risk assessment; Classification & labelling; Lowest observed effect level; Offspring generation

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

On the impact of second generation mating and offspring in multi-generation reproductive toxicity studies on classification and labelling of substances in Europe

Keywords: دستورالعمل آزمون; Multi-generation reproductive toxicity; Extended One Generation Reproductive Toxicity Study (EOGRTS); Test guideline; Developmental toxicity; Classification and labelling (EU C&L);

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

In house validation of recombinant yeast estrogen and androgen receptor agonist and antagonist screening assays

Keywords: دستورالعمل آزمون; YES; yeast estrogen screening; YAS; yeast androgen screening; A; androgen/-ic; AA; antiandrogen/-ic; AE; antiestrogen/-ic; AR; androgen receptor; E; estrogen/-ic; ER; estrogen receptor; hERα; human estrogen receptor α; hAR; human androgen receptor; TA;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه