کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5561385 | 1562118 | 2017 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lacking applicability of in vitro eye irritation methods to identify seriously eye irritating agrochemical formulations: Results of bovine cornea opacity and permeability assay, isolated chicken eye test and the EpiOcular⢠ET-50 method to classify acco
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کلمات کلیدی
Isolated Chicken Eye testIVISCATEURL ECVAMBCOPEITHSIOECDAAALACUN GHS - GHSHET-CAM - HET CAMEye irritation test - آزمون تحریک چشمAssociation for Assessment and Accreditation of Laboratory Animal Care - انجمن ارزیابی و اعتباربخشی مراقبت از حیوانات آزمایشگاهیstandard deviation - انحراف معیارPresent - حاضرBovine Corneal Opacity and Permeability - خلوص و نفوذپذیری قرنیه گاوCategory - دسته بندیtest guideline - دستورالعمل آزمونOrganization for Economic Co-operation and Development - سازمان همکاری و توسعه اقتصادیClassification - طبقه بندیisolated chicken eye - چشم مرغ جدا شدهoptical density - چگالی نوریcorneal opacity - کدورت قرنیهnegative control - کنترل منفیIATA - یاتاIce - یخ
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In vitro methods have gained regulatory acceptance for the prediction of serious eye damage (UN GHS Cat 1). However, the majority of in vitro methods do not state whether they are applicable to agrochemical formulations. This manuscript presents a study of up to 27 agrochemical formulations tested in three in vitro assays (three versions of the bovine corneal opacity and permeability test (BCOP, OECD TG 437) assay, the isolated chicken eye test (ICE, OECD TG 438) and the EpiOcular⢠ET-50 assay). The results were compared with already-available in vivo data. In the BCOP only one of the four, one of five in the ICE and six of eleven tested formulations in the EpiOcular⢠ET-50 Neat Protocol resulted in the correct UN GHS Cat 1 prediction. Overpredictions occurred in all assays. These data indicate a lack of applicability of the three in vitro methods to reliably predict UN GHS Cat 1 of agrochemical formulations. In order to ensure animal-free identification of seriously eye damaging agrochemical formulations testing protocols and/or prediction models need to be modified or classification rules should be tailored to in vitro testing rather than using in vivo Draize data as a standard.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 85, April 2017, Pages 33-47
Journal: Regulatory Toxicology and Pharmacology - Volume 85, April 2017, Pages 33-47
نویسندگان
Susanne N. Kolle, Andrew Van Cott, Bennard van Ravenzwaay, Robert Landsiedel,