کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8553893 | 1562696 | 2018 | 50 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CON4EI: Development of testing strategies for hazard identification and labelling for serious eye damage and eye irritation of chemicals
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کلمات کلیدی
EU CLPRhCEreconstructed human cornea-like epitheliumCON4EIReference chemicalsSlug Mucosal IrritationCAS RNBCOPSTESMIHCEguidance documentEITEURLWntCONsortium for in vitro Eye Irritation testing strategyDRDOECDUN GHS classification for chemicals causing irreversible effects on the eye/serious damage to the eyeUN GHS - GHSEye irritation test - آزمون تحریک چشمTesting strategies - استراتژی های تستHuman corneal epithelium - اپیتلیوم قرنیه انسانیNo Cat - بدون گربهOcular irritation - تحریک چشمBovine Corneal Opacity and Permeability - خلوص و نفوذپذیری قرنیه گاوtest guideline - دستورالعمل آزمونChemical Abstracts Service Registry Number - رجیستری شماره سرویس های شیمیاییUnited Nations Globally Harmonized System of Classification and Labelling of Chemicals - سازمان ملل متحد سیستم جهانی طبقه بندی و برچسب زدن مواد شیمیاییOrganisation for Economic Co-operation and Development - سازمان همکاری اقتصادی و توسعهPers - شخصیتPersistence - ماندگاریisolated chicken eye - چشم مرغ جدا شدهcorneal opacity - کدورت قرنیهnegative control - کنترل منفیCat 1 - گربه 1Cat 2 - گربه 2Ice - یخ
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Assessment of acute eye irritation potential is part of the international regulatory requirements for safety testing of chemicals. In the last decades, many efforts have been made in the search for alternative methods to replace the regulatory in vivo Draize rabbit eye test (OECD TG 405). Success in terms of complete replacement of the regulatory in vivo Draize rabbit eye test has not yet been achieved. The main objective of the CEFIC-LRI-AIMT6-VITO CON4EI (CONsortium for in vitro Eye Irritation testing strategy) project was to develop tiered testing strategies for serious eye damage and eye irritation assessment that can lead to complete replacement of OECD TG 405. A set of 80 reference chemicals (e.g. balanced by important driver of classification and physical state), was tested with seven test methods. Based on the results of this project, three different strategies were suggested. We have provided a standalone (EpiOcular ET-50), a two-tiered and three-tiered strategy, that can be used to distinguish between Cat 1 and Cat 2 chemicals and chemicals that do not require classification (No Cat). The two-tiered and three-tiered strategies use an RhCE test method (EpiOcular EIT or SkinEthic⢠EIT) at the bottom (identification No Cat) in combination with the BCOP LLBO (two-tiered strategy) or BCOP OP-KIT and SMI (three-tiered strategy) at the top (identification Cat 1). For our proposed strategies, 71.1% - 82.9% Cat 1, 64.2% - 68.5% Cat 2 and â¥Â 80% No Cat chemicals were correctly identified. Also, similar results were obtained for the Top-Down and Bottom-Up approach.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 49, June 2018, Pages 99-115
Journal: Toxicology in Vitro - Volume 49, June 2018, Pages 99-115
نویسندگان
E. Adriaens, S. Verstraelen, N. Alépée, H. Kandarova, A. Drzewiecka, K. Gruszka, R. Guest, J.A. Sr., A.R. Van Rompay,