کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8553880 | 1562696 | 2018 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CON4EI: Short Time Exposure (STE) test method for hazard identification and labelling of eye irritating chemicals
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کلمات کلیدی
UN GHS classification for chemicals causing irreversible effects on the eye/serious damage to the eyeCONsortium for in vitro Eye Irritation testing strategySLSDPBSSIRCOECDDRDFPRFNRCON4EISTEDMSO - DMSOUN GHS - GHSOcular irritation - تحریک چشمtest guideline - دستورالعمل آزمونDimethyl sulfoxide - دیمتیل سولفواکسیدUnited Nations Globally Harmonized System of Classification and Labelling of Chemicals - سازمان ملل متحد سیستم جهانی طبقه بندی و برچسب زدن مواد شیمیاییOrganization for Economic Co-operation and Development - سازمان همکاری و توسعه اقتصادیsodium lauryl sulfate - سدیم لوریل سولفاتPers - شخصیتDulbecco's phosphate buffered saline - فسفات باسیل نمک DulbeccoPersistence - ماندگاریFalse positive rate - نرخ مثبت کاذبFalse negative rate - نرخ منفی کاذبoptical density - چگالی نوریcorneal opacity - کدورت قرنیهSolvent control - کنترل حلالPositive control - کنترل مثبتCONJ - کنجکاوCat 1 - گربه 1Cat 2 - گربه 2
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The accuracy of the STE test method to identify Cat 1 chemicals was 61.3% with 23.7% sensitivity and 95.2% specificity. If non-soluble chemicals and unqualified results were excluded, the performance to identify Cat 1 chemicals remained similar (accuracy 62.2% with 22.7% sensitivity and 100% specificity). The accuracy of the STE test method to identify No Cat chemicals was 72.5% with 66.2% sensitivity and 100% specificity. Excluding highly volatile chemicals, non-surfactant solids and non-qualified results resulted in an important improvement of the performance of the STE test method (accuracy 96.2% with 81.8% sensitivity and 100% specificity). Furthermore, it seems that solids are more difficult to test in the STE, 71.4% of the solids resulted in unqualified results (solubility issues and/or high variation between independent runs) whereas for liquids 13.2% of the results were not qualified, supporting the restriction of the test method regarding the testing of solids.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 49, June 2018, Pages 65-76
Journal: Toxicology in Vitro - Volume 49, June 2018, Pages 65-76
نویسندگان
E. Adriaens, J.A. Sr., B.R. Meyer, L.C. Blakeman, N. Alépée, P. Fochtman, R. Guest, H. Kandarova, S. Verstraelen, A.R. Van Rompay,