کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5856415 | 1562127 | 2016 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Case studies putting the decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping) into practice
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کلمات کلیدی
DLSDPPGbauADOPGCphALFDNPCATDPPAOPDMEMAUC - AUCDulbecco's modified Eagle Medium - Eagle Medium اصلاح شده DulbeccoAAN - ONanalytical ultracentrifugation - ultracentrifugation تحلیلیCellular effects - اثرات سلولیAMA - اماAtomic adsorption - جذب اتمیRead-Across - خواندن در سراسرCategory - دسته بندیOrganic pigments - رنگدانه های آلیCentrophenoxine - سنتورفنکسینBET - شرطadverse outcome pathway - مسیر ناخوشایندDynamic Light Scattering - پراکندگی نور دینامیکیGrouping - گروه بندی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Case studies covering carbonaceous nanomaterials, metal oxide and metal sulphate nanomaterials, amorphous silica and organic pigments were performed to assess the Decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping). The usefulness of the DF4nanoGrouping for nanomaterial hazard assessment was confirmed. In two tiers that rely exclusively on non-animal test methods followed by a third tier, if necessary, in which data from rat short-term inhalation studies are evaluated, nanomaterials are assigned to one of four main groups (MGs). The DF4nanoGrouping proved efficient in sorting out nanomaterials that could undergo hazard assessment without further testing. These are soluble nanomaterials (MG1) whose further hazard assessment should rely on read-across to the dissolved materials, high aspect-ratio nanomaterials (MG2) which could be assessed according to their potential fibre toxicity and passive nanomaterials (MG3) that only elicit effects under pulmonary overload conditions. Thereby, the DF4nanoGrouping allows identifying active nanomaterials (MG4) that merit in-depth investigations, and it provides a solid rationale for their sub-grouping to specify the further information needs. Finally, the evaluated case study materials may be used as source nanomaterials in future read-across applications. Overall, the DF4nanoGrouping is a hazard assessment strategy that strictly uses animals as a last resort.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 76, April 2016, Pages 234-261
Journal: Regulatory Toxicology and Pharmacology - Volume 76, April 2016, Pages 234-261
نویسندگان
Josje H.E. Arts, Muhammad-Adeel Irfan, Athena M. Keene, Reinhard Kreiling, Delina Lyon, Monika Maier, Karin Michel, Nicole Neubauer, Thomas Petry, Ursula G. Sauer, David Warheit, Karin Wiench, Wendel Wohlleben, Robert Landsiedel,