کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5649082 | 1407116 | 2017 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chemical photoallergy: photobiochemical mechanisms, classification, and risk assessments
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کلمات کلیدی
photoirritation factor3T3 NRU PTAOPLLNANSAIDSPIFMECiFRa - IFRAP-aminobenzoic acid - P-آمینو بنزوئیک اسیدROS - ROSLocal lymph node assay - آزمایش گره لنفاوی محلیUltraviolet - اشعه فرابنفشQSAR - بزرگسال Photosensitivity - حساسیت به نور، فوتوسنسیتیویNon-steroidal anti-inflammatory drugs - داروهای ضد التهابی غیر استروئیدیDEREK - دورکQuantitative structure-activity relationships - روابط فعالیت ساختاری کمیHOMO-LUMO gap - شکاف HOMO-LUMOMolar extinction coefficient - ضریب انقراض مولیPhotoallergy - عکس آلرژیPhototoxicity - فتوتوکسیسیتیadverse outcome pathway - مسیر ناخوشایندICH - منVisible light - نور مرئیPABA - پاباReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Chemical photoallergy: photobiochemical mechanisms, classification, and risk assessments Chemical photoallergy: photobiochemical mechanisms, classification, and risk assessments](/preview/png/5649082.png)
چکیده انگلیسی
Chemical photosensitivity can be elicited by exposure of the skin to various pharmaceutical substances, foods, cosmetics and other environmental chemicals, followed by exposure to sunlight. There are at least three types of chemical photosensitivity, i.e., photoirritancy (narrowly defined as phototoxicity), photogenotoxicity and photoallergenicity, and their clinical characteristics and mechanisms are quite different. Concerns about chemical photoallergy is increasing, and various studies have been made to clarify the photobiochemical characteristics of photoallergens and the mechanisms involved. Various methodologies, including in silico prediction models, photochemical assay systems, and in vitro phototoxicity prediction tools, have been developed to predict the photoallergenic potential of chemicals over the past few years. The aim of this manuscript is to review the clinical characteristics, pathogenetic mechanisms and photobiochemical features of photoallergens, with special emphasis on the current status about development of screening systems for predicting photoallergenic potential of chemicals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Dermatological Science - Volume 85, Issue 1, January 2017, Pages 4-11
Journal: Journal of Dermatological Science - Volume 85, Issue 1, January 2017, Pages 4-11
نویسندگان
Satomi Onoue, Yoshiki Seto, Hideyuki Sato, Hayato Nishida, Morihiko Hirota, Takao Ashikaga, Anne Marie Api, David Basketter, Yoshiki Tokura,