کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8553966 | 1562695 | 2018 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme
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کلمات کلیدی
MOALRSSSEURAT-1ITTCabsorption, distribution, metabolism, eliminationFDAToxicodynamicsEURL ECVAMQIVIVETRVPBPKPODAOPADMETTCOECDEFSAUS EPA - EPA ایالات متحدهEuropean Union Reference Laboratory for Alternatives to Animal Testing - آزمایشگاه مرجع اتحادیه اروپا برای جایگزینی برای تست حیواناتThreshold of toxicological concern - آستانه نگرانی سمیUS Environmental Protection Agency - آژانس حفاظت از محیط زیست ایالات متحدهUS Food and Drug Administration - اداره غذا و داروی ایالات متحدهSafety assessment - ارزیابی ایمنیToxicokinetics - تاکسیکوسینتیک، تاکسیکوکینتیکMode of action - حالت عملAlternative methods - روش های جایگزینIntegrated approaches to testing and assessment - روشهای یکپارچه برای تست و ارزیابیOrganisation for Economic Cooperation and Development - سازمان همکاری اقتصادی و توسعهSystemic toxicity - سمیت سیستمیکphysiologically based pharmacokinetics - فارماکوکینتیک مبتنی بر فیزیولوژی استadverse outcome pathway - مسیر ناخوشایندPoint of departure - نقطه عزیمتIATA - یاتا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
When performing safety assessment of chemicals, the evaluation of their systemic toxicity based only on non-animal approaches is a challenging objective. The Safety Evaluation Ultimately Replacing Animal Test programme (SEURAT-1) addressed this question from 2011 to 2015 and showed that further research and development of adequate tools in toxicokinetic and toxicodynamic are required for performing non-animal safety assessments. It also showed how to implement tools like thresholds of toxicological concern (TTCs) and read-across in this context. This paper shows a tiered scientific workflow and how each tier addresses the four steps of the risk assessment paradigm. Cosmetics Europe established its Long Range Science Strategy (LRSS) programme, running from 2016 to 2020, based on the outcomes of SEURAT-1 to implement this workflow. Dedicated specific projects address each step of this workflow, which is introduced here. It tackles the question of evaluating the internal dose when systemic exposure happens. The applicability of the workflow will be shown through a series of case studies, which will be published separately. Even if the LRSS puts the emphasis on safety assessment of cosmetic relevant chemicals, it remains applicable to any type of chemical.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 50, August 2018, Pages 137-146
Journal: Toxicology in Vitro - Volume 50, August 2018, Pages 137-146
نویسندگان
Bertrand Desprez, Matt Dent, Detlef Keller, Martina Klaric, Gladys Ouédraogo, Richard Cubberley, Hélène Duplan, Joan Eilstein, Corie Ellison, Sébastien Grégoire, Nicola J. Hewitt, Carine Jacques-Jamin, Daniela Lange, Amy Roe, Helga Rothe,