Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; Elderly; Clinical pharmacology; Specific populations; Physiologically based pharmacokinetics; Dose optimization; Personalized medicine; Pharmacometrics;
مقالات ISI فارماکوکینتیک مبتنی بر فیزیولوژی است (ترجمه نشده)
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Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; Oral absorption; Paediatrics; Physiologically based pharmacokinetics; Bioavailability; Absorption rate;
Quantitative estimation of cholinesterase-specific drug metabolism of carbamate inhibitors provided by the analysis of the area under the inhibition-time curve
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; AChE; acetylcholinesterase (EC 3.1.1.7); ADME; absorption, distribution, metabolism, excretion; AUC; area under the concentration-time curve; AUIC; area under the inhibition-time curv; BChE; butyrylcholinesterase (EC 3.1.1.8); BTCh; butyrylthiocholine; DT
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; biliary excretion; drug interactions; efflux pumps; MRP; permeability; ATV; atorvastatin; MET; metformin; 2-OH ATV; 2-hydroxyatorvastatin; CYP; cytochrome P450; MDCK; Madin-Darby canine kidney; MDR; multidrug resistance gene; BCRP; breast cancer resistanc
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; physiologically based pharmacokinetic modeling; drug interactions; Monte Carlo; in vitro-in vivo correlations (IVIVC); nonlinear regression; biliary excretion; biliary recycling; hepatic metabolism; hepatic transport; AUC; area under the curve of concen
A Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug-Drug Interactions of Buprenorphine After Subcutaneous Administration of CAM2038 With Perpetrators of CYP3A4
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; buprenorphine; drug-drug interaction; physiologically based pharmacokinetics; ketoconazole; rifampin;
A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; ADME; absorption, distribution, metabolism, elimination; AOP; adverse outcome pathway; EFSA; European Food and Safety Agency; EURL ECVAM; European Union Reference Laboratory for Alternatives to Animal Testing; FDA; US Food and Drug Administration; IATA; I
Mechanistic Physiologically Based Pharmacokinetic Modeling of the Dissolution and Food Effect of a Biopharmaceutics Classification System IV Compound-The Venetoclax Story
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; amorphous; absorption, distribution, metabolism, and excretion (ADME); bioavailability; food effect; physiologically based pharmacokinetic modeling; clinical pharmacokinetics; intestinal absorption; passive diffusion/transport; drug interaction; ASD; Amor
Pharmacokinetics of [14C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; Pharmacokinetics; Benzo[a]pyrene; Accelerator mass spectrometry; Dietary polycyclic aromatic hydrocarbons; ADME; absorption distribution metabolism and excretion; AFB1; aflatoxin B1; AMS; accelerator mass spectrometry; ATDSR; Agency for Toxic Substances a
Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; Biorelevant dissolution; Weak base; PBPK modeling; BCS class II; pH dependent solubility; ACAT; advanced compartmental absorption and transit model; ADAM; advanced dissolution, absorption and metabolism model; API; active pharmaceutical ingredient; ASD;
Evaluation of Drug-Drug Interaction Potential Between Sacubitril/Valsartan (LCZ696) and Statins Using a Physiologically Based Pharmacokinetic Model
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; physiologically based pharmacokinetic modeling; transporters; statin; absorption; organic anion-transporting polypeptide; drug-drug interaction; AUC; area under the plasma concentration-time curve; Cmax; maximum plasma concentration; CLint,T; transporter-
Prediction of in vivo developmental toxicity by combination of Hand1-Luc embryonic stem cell test and metabolic stability test with clarification of metabolically inapplicable candidates
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; EST; embryonic stem cell test; ECVAM; European Center for the Validation of Alternative Methods; PBPK; physiologically based pharmacokinetics; MIC; metabolically inapplicable candidate; PBS; phosphate buffered saline; DMSO; dimethyl sulfoxide; MD; maximum
A Physiologically Based Pharmacokinetic Model to Describe Artemether Pharmacokinetics in Adult and Pediatric Patients
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; clinical pharmacokinetics; CYP enzymes; drug metabolizing enzymes; elimination; hepatic clearance; interspecies scaling; physiologically based pharmacokinetic modeling; preclinical pharmacokinetics; simulations; AUC; area under the plasma concentration-ti
PBPK model of methotrexate in cerebrospinal fluid ventricles using a combined microdialysis and MRI acquisition
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; CSF; cerebrospinal fluid; MTX; methotrexate; PET; positron emission tomography; PBPK; Physiologically Based Pharmacokinetics; MRI; magnetic resonance imaging; IM; intramuscular administration; IV; intravenous administration; Gd-DOTA; gadolinium chelate; A
In silico methods for predicting drug-drug interactions with cytochrome P-450s, transporters and beyond
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; Cheminformatics; Computational; Docking; Machine learning; Modeling; Pharmacophore; Physiologically based pharmacokinetics;
Prediction of Total Hepatic Clearance by Combining Metabolism, Transport, and Permeability Data in the In Vitro-In Vivo Extrapolation Methods: Emphasis on an Apparent Fraction Unbound in Liver for Drugs
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; hepatocytes; intrinsic clearance; unbound fraction; metabolism; transport; permeability; in vitro-in vivo extrapolation; in vitro-in vivo correlation; IVIVE; pharmacokinetics; physiologically based pharmacokinetics; PBPK modeling;
Toward a new paradigm for the efficient in vitro–in vivo extrapolation of metabolic clearance in humans from hepatocyte data
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; hepatocytes; intrinsic clearance; unbound fraction; computational ADME; in vitro–in vivo extrapolation; in vitro–in vivo correlation; IVIVE; pharmacokinetics; physiologically based pharmacokinetics; PBPK modeling
Inter-individual Variability of In Vivo CYP2D6 Activity in Different Genotypes
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; inter-individual variability; CYP2D6; Monte Carlo simulation; physiologically based pharmacokinetics; pharmacogenetics; dextromethorphan; drug discovery;
Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; physiologically based pharmacokinetics; CYP3A4; P-glycoprotein; Intestinal absorption; pharmacokinetics;
Pharmacokinetic simulator with three-dimensional graphical models: Sociotechnological interface of pharmacokinetics for medical personnel, patients, and medicinal chemists
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; Physiologically based pharmacokinetics; Graphical user interface; Social technology;
Dynamical coupling of PBPK/PD and AUC-based toxicity models for arsenic in tilapia Oreochromis mossambicus from blackfoot disease area in Taiwan
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی است; Arsenic; Area-under-curve; Blackfoot disease; Modeling; Physiologically based pharmacokinetics; Pharmacodynamics; Tilapia;