Keywords: روش های جایگزین; Developmental neurotoxicity; Methylmercury; Glucocorticoid receptor; Endocrine disruptor; Alternative methods;
مقالات ISI روش های جایگزین (ترجمه نشده)
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Keywords: روش های جایگزین; Membrane transporters; Active transport; Toxicokinetics; Chemical risk assessment; Alternative methods; Survey;
Keywords: روش های جایگزین; Safety of machinery; Lockout; Equipment; Regulation; Alternative methods;
Keywords: روش های جایگزین; ANOVA; analysis of variance; APC; antigen presenting cell; AZPR; azathioprine; BA; Pbenzo(a)pyrene; CYA; cyclosporin A; CYPH; cyclophosphamide monohydrate; DEX; dexamethasone; DPBS; Dulbecco's phosphate-buffered saline; DMSO; dimethylsulfoxide; ELISA; enz
Keywords: روش های جایگزین; Global coalition; Emerging technologies; Food safety; Drug safety; Regulatory agencies; Alternative methods; Best practices; Cross-training;
Keywords: روش های جایگزین; Embryo-fetal developmental toxicity; Database; Alternative methods; Cross-species analysis;
Keywords: روش های جایگزین; Thyroid disruption; Alternative methods; MTT; Thyroid gland culture;
Keywords: روش های جایگزین; Monocyte activation test; Rabbit pyrogen test; Alternative methods; Lipoteichoic acid; Gram-positive bacteria; Sanitary surveillance; Human cryopreserved whole blood;
Keywords: روش های جایگزین; Reproductive toxicity; Oocyte; Spermatozoa; ReProTect; Fertilization; Bovine; Alternative methods; 3Rs principle;
Keywords: روش های جایگزین; Risk assessment; Toxicology; Skin; Cosmetics; Alternative methods; Ãvaluation du risque; Toxicologie; Peau; Cosmétiques; Méthodes alternatives;
Keywords: روش های جایگزین; AUC; area under the curve; BPA; bisphenol A; BUP; bitumen upgrading product; BR; bayrepel; CAP; trans-capsaicin; COM; complex organic mixture; CSO; clarified slurry oil; DAE; distillate aromatic extract; DDT; dichlorodiphenyltrichloroethane; DEET; N,N-Die
Keywords: روش های جایگزین; Skin sensitization; Alternative methods; In vitro; Keratinocytes; Toxicogenomics;
Keywords: روش های جایگزین; Alternative methods; Skin irritation; SkinEthic; Greasy/sticky chemicals testing; Botanical ingredients; Washing procedures;
CON4EI: Development of serious eye damage and eye irritation testing strategies with respect to the requirements of the UN GHS/EU CLP hazard categories
Keywords: روش های جایگزین; BCOP; Bovine Corneal Opacity and Permeability; CON4EI; CONsortium for in vitro Eye Irritation testing strategy; EpiOcular⢠EIT; EpiOcular Eye Irritation Test; EpiOcular⢠ET-50; EpiOcular Time-to-toxicity; EU CLP; European Union Regulation on Classific
Derivation of an inhalation TTC for the workplace based on DNEL values reported under REACH
Keywords: روش های جایگزین; TTC; Threshold of toxicological concern; Inhalation toxicity; Risk assessment; Reach; Alternative methods;
Characterization of 3D embryonic C57BL/6 and A/J mouse midbrain micromass in vitro culture systems for developmental neurotoxicity testing
Keywords: روش های جایگزین; 3D organotypic culture; Developmental neurotoxicology; Alternative methods; Micromass; Gene x environment;
A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme
Keywords: روش های جایگزین; ADME; absorption, distribution, metabolism, elimination; AOP; adverse outcome pathway; EFSA; European Food and Safety Agency; EURL ECVAM; European Union Reference Laboratory for Alternatives to Animal Testing; FDA; US Food and Drug Administration; IATA; I
Endocrine Disruptors: Data-based survey of in vivo tests, predictive models and the Adverse Outcome Pathway
Keywords: روش های جایگزین; Endocrine Disruptors; Alternative methods; Human health; Modelling; Prediction; Adverse Outcome Pathways; High-throughput;
In vitro genotoxicity testing-Can the performance be enhanced?
Keywords: روش های جایگزین; Genotoxicity; In vitro mammalian cell test; Safety assessment; Alternative methods; Carc; carcinogenicity; CAvit; in vitro chromosomal aberration test; CAviv; in vivo chromosomal aberration test; DB; database; DNAviv; in vivo DNA strand breakage (e.g. co
Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop
Keywords: روش های جایگزین; Carcinogenicity; Alternative methods; Rodent bioassay; Toxicogenomics; Mechanisms; Cancer hallmarks; CTA;
Endocrine and physiological effects of linuron and S-metolachlor in zebrafish developing embryos
Keywords: روش های جایگزین; Alternative methods; Endocrine disruption; Fish embryo toxicity; Neurotoxicity; Oxidative stress; Teratogenic effects;
Toxicity evaluation of the photoprotective compound LQFM048: Eye irritation, skin toxicity and genotoxic endpoints
Keywords: روش های جایگزین; Alternative methods; Eye irritation; Genotoxicity; Heterocyclic derivative; Phototoxicity; Skin sensitization;
(Q)SAR tools for priority setting: A case study with printed paper and board food contact material substances
Keywords: روش های جایگزین; (Q)SAR; Mutagenicity; Prioritization; Food contact materials; Alternative methods; AD(I); applicability domain (index); ECHA; European Chemicals Agency; EFSA; European Food Safety Authority; FACET; Flavours, Additives and food Contact materials Exposure T
In vitro safety and efficacy evaluations of a complex botanical mixture of Eugenia dysenterica DC. (Myrtaceae): Prospects for developing a new dermocosmetic product
Keywords: روش های جایگزین; AAAPVN; N-succinyl-ala-ala-ala-p-nitroanilide; BCOP; Bovine Corneal Opacity and Permeability; CBPI; cytokinesis-block proliferation index; CV80; non-cytotoxic concentration of test substance that maintain cell viability â¥Â 80%; DNCB; 1-chloro-2,4-dinitr
Performance of two alternative methods for Listeria detection throughout Serro Minas cheese ripening
Keywords: روش های جایگزین; Listeria; Raw milk cheese; Alternative methods
Analysis of the Local Lymph Node Assay (LLNA) variability for assessing the prediction of skin sensitisation potential and potency of chemicals with non-animal approaches
Keywords: روش های جایگزین; ACE; acetone; AOO; acetone:olive oil (4:1 by volume); DMF; dimethylformamide; EC3; effective concentration inducing a stimulation index of 3; ETOH/DEP; Ethanol/diethylphthalate; EXT; extreme (ECETOC classification); IDR; Insufficient Dose Response; MOD; m
Skin sensitizer identification by IL-8 secretion and CD86 expression on THP-1 cells
Keywords: روش های جایگزین; CD, cluster of differentiation; LLNA, local lymph node assay; MFI, mean fluorescence intensity; TNF-α, tumor necrosis factor-alfaAllergenicity; Sensitizer; In vitro test; Alternative methods
Correlation between ToBI test and in vivo titration for diphtheria and tetanus
Keywords: روش های جایگزین; ToBI test; Vaccines; Quality control; Hyperimmune sera; Alternative methods
Allele-specific PCR for quantitative analysis of mutants in live viral vaccines
Keywords: روش های جایگزین; Oral Polio Vaccine; Virulent revertants; Consistency monitoring; MAPREC; Alternative methods;
Introduction of a methoxymethyl side chain into p-phenylenediamine attenuates its sensitizing potency and reduces the risk of allergy induction
Keywords: روش های جایگزین; PPD; p-phenylenediamine; PTD; p-toluylenediamine; ME-PPD; 2-methoxymethyl-p-phenylenediamine; LLNA; local lymph node assay; QRA; quantitative risk assessment; SCCS; Scientific Committee on Consumer Safety; HE-PPD; hydroxyethyl-PPD; WoE; weight-of-evidence
Report on the international workshop on alternatives to the murine histamine sensitization test (HIST) for acellular pertussis vaccines: State of the science and the path forward
Keywords: روش های جایگزین; Pertussis toxin; Acellular pertussis vaccines; Alternative methods; Safety; Biochemical assays; Cell-based assays;
Optimizing the aquatic toxicity assessment under REACH through an integrated testing strategy (ITS)
Keywords: روش های جایگزین; ACR; acute-to-chronic ratios; AF; assessment factor; BCF; bioconcentration factor; BOD5; 5-days biochemical oxygen demand; C&L; classification and labeling; CLP; classification, labeling and packaging; COD; chemical oxygen demand; CSA; chemical safety ass
Automatic sorting of toxicological information into the IUCLID (International Uniform Chemical Information Database) endpoint-categories making use of the semantic search engine Go3R
Keywords: روش های جایگزین; Semantic search engine; REACH; Registration dossiers; Regulatory toxicology; Data sharing; Alternative methods; 3Rs principle;
The GARD assay for assessment of chemical skin sensitizers
Keywords: روش های جایگزین; ACD; allergic contact dermatitis; AHR; aryl hydrocarbon receptor; DC; dendritic cell; DMSO; dimethyl sulfoxide; IFN; interferon; LC; langerhans cell; LLNA; local lymph node assay; LMW; low molecular weight; NRF2; nuclear factor-erythroid 2-related factor
Establishment of a new in vitro test method for evaluation of eye irritancy using a reconstructed human corneal epithelial model, LabCyte CORNEA-MODEL
Keywords: روش های جایگزین; Reconstructed human corneal epithelium; Eye irritation; Alternative methods; LabCyte CORNEA-MODEL; In vitro; Ocular
Report on the international workshop on alternative methods for Leptospira vaccine potency testing: State of the science and the way forward
Keywords: روش های جایگزین; Leptospira vaccines; Alternative methods; Potency; Replacement; Refinement; Reduction
Housing of rabbit does: Group and individual systems: A review
Keywords: روش های جایگزین; Rabbit does; Housing systems; Group-housing; Alternative methods;
Guiding principles for the implementation of non-animal safety assessment approaches for cosmetics: Skin sensitisation
Keywords: روش های جایگزین; ACD; allergic contact dermatitis; AEL; acceptable exposure level; APC; antigen presenting cells; CEL; consumer exposure level; CIR; cosmetic ingredient review; COLIPA; the European Cosmetics Association; DC; dendritic cells; DPRA; direct peptide reactivit
Automation of an in vitro cytotoxicity assay used to estimate starting doses in acute oral systemic toxicity tests
Keywords: روش های جایگزین; High throughput screening; Cytotoxicity; Acute oral toxicity; Validation; Safety assessment; Alternative methods;
Putting the parts together: Combining in vitro methods to test for skin sensitizing potentials
Keywords: روش های جایگزین; ARE; antioxidant response element; AUC; area under the curve; C.C; control cells; CV75; concentration reducing viability to 75%; DC; dendritic cells; DMSO; dimethyl sulfoxide; DNCB; 1-chloro-2,4-dinitrobenzene; DPRA; Direct Peptide Reactivity Assay; ECHA;
In vitro cytokine release from human peripheral blood mononuclear cells in the assessment of the immunotoxic potential of chemicals
Keywords: روش های جایگزین; Immunotoxicity; In vitro; Cytokines; Cell proliferation; Peripheral blood mononuclear cells; Alternative methods;
Different sensitivity of BALB/c 3T3 cell clones in the response to carcinogens
Keywords: روش های جایگزین; Cell transformation assay; Alternative methods; Carcinogens; Metabolic activation; REACHACE, absolute clonal efficiency; B(a)P, benzo(a)pyrene; 1,2-DBE, 1,2 dibromoethane; CTA, cell transformation assay; GSH, glutathione; 3-MCA, 3-methylcholanthrene; MEL,
From alternative methods to a new toxicology
Keywords: روش های جایگزین; Alternative methods; Animal testing; Toxicology; Validation; Evidence-based medicine; Omics technologies;
Evaluating the sensitization potential of surfactants: Integrating data from the local lymph node assay, guinea pig maximization test, and in vitro methods in a weight-of-evidence approach
Keywords: روش های جایگزین; Alternative methods; Skin sensitization; Guinea pig maximization test (GPMT); hCLAT; Irritation; KeratinoSens assay; Local lymph node assay (LLNA); Peptide reactivity assay; Regulatory tests; Weight of evidence;
Application of a multiple endpoint bacterial reporter assay to evaluate toxicological relevant endpoints of perfluorinated compounds with different functional groups and varying chain length
Keywords: روش های جایگزین; Reporter assay; Perfluorinated compounds; Escherichia coli; Varying chain length; Bacterial reporter assay; Alternative methods
Transferability and inter-laboratory variability assessment of the in vitro bovine oocyte maturation (IVM) test within ReProTect
Keywords: روش های جایگزین; Reproductive toxicity; Female germ cells; ReProTect; Maturation; Bovine oocytes; Alternative methods
A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: Genotoxicity. A COLIPA analysis
Keywords: روش های جایگزین; Genotoxicity; Cosmetic ingredients; Alternative methods; Hazard assessment; Safety assessment;
Behavioral toxicology in the 21st century: Challenges and opportunities for behavioral scientists: Summary of a symposium presented at the annual meeting of the Neurobehavioral Teratology Society, June, 2009
Keywords: روش های جایگزین; Toxicity testing; Toxicity pathway; Behavioral toxicology; Thyroid hormone pathway; Narcosis pathway; Phthalates; Alternative methods; Risk assessment
A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: Skin irritation
Keywords: روش های جایگزین; Skin irritation; Safety assessment; Alternative methods;
A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: Eye irritation
Keywords: روش های جایگزین; Eye irritation; Alternative methods; Safety assessment; Cosmetics;