کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5858083 1562161 2015 96 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
What happens in the skin? Integrating skin permeation kinetics into studies of developmental and reproductive toxicity following topical exposure
ترجمه فارسی عنوان
چه اتفاقی می افتد در پوست؟ ترکیب سینتیک نفوذ پوست به مطالعات مربوط به سمیت تولید و تولید مثل پس از قرار گرفتن در معرض موضعی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Animal-based developmental and reproductive toxicological studies involving skin exposure rarely incorporate information on skin permeation kinetics. For practical reasons, animal studies cannot investigate the many factors which can affect human skin permeation and systemic uptake kinetics in real-life scenarios. Traditional route-to-route extrapolation is based on the same types of experiments and requires assumptions regarding route similarity. Pharmacokinetic modeling based on skin physiology and structure is the most efficient way to incorporate the variety of intrinsic skin and exposure-dependent parameters occurring in clinical and occupational settings into one framework. Physiologically-based pharmacokinetic models enable the integration of available in vivo, in vitro and in silico data to quantitatively predict the kinetics of uptake at the site of interest, as needed for 21st century toxicology and risk assessment. As demonstrated herein, proper interpretation and integration of these data is a multidisciplinary endeavor requiring toxicological, risk assessment, mathematical, pharmaceutical, biological and dermatological expertise.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 58, December 2015, Pages 252-281
نویسندگان
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