Keywords: Spermine (PubChem CID1103); Spermidine (PubChem CID1102); Biogenic amines; Cytotoxicity; Food safety; Spermine; Spermidine; IC50; NOAEL; LOAEL;
مقالات ISI (ترجمه نشده)
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Keywords: NOAEL; no observed adverse effect level; LOAEL; lowest observed adverse effect level; MRL; minimal risk level; JECFA; joint expert committee on food additives; ATSDR; agency for toxic substances and disease registry; PTWI; provisional tolerable weekly int
Keywords: β-HCH; β-hexachlorocyclohexane; µg/l; microgram per liter; µM/l; micromolar per liter; Ʃ; total; 1-HP; 1-hydroxypyrene; 2; 3-DHBA, 2,3-dihydroxybenzoic Acid; 2cx-MMHP; mono-(2-carboxymethylhexyl) phthalate; 3PBA; 3-phenoxybenzoic acid; 4F3PBA; 4-fluo
Keywords: Health risk assessment; Air freshener consumer products; Inhalation and dermal hazard; Fragrance ingredients; Tiered 1 and 2 risk assessment; IAQ; indoor air quality; KME; Korean Ministry of Environment; KNLIC; Korean National Law Information Center; SCCN
Keywords: ADME; Absorption, Distribution, Metabolism, Excretion; AOPs; adverse outcome pathways; AUC; Area under the Curve; AEs; assessment elements; AOs; assessment options; BMDL; benchmark dose lower bound; CAAT; Center for Alternatives to Animal Testing; Cefic-L
Keywords: Food allergy; Walnut; Allergen thresholds; Threshold dose distributions; Eliciting doses; DBPCFC; Double-blind, placebo-controlled food challenge; ED; Eliciting doses; ICSA; Interval-Censoring Survival Analysis; LOAEL; Lowest observed adverse effect level
Keywords: Honokiol microemulsion; Cerebral ischemia protection; Embryo-fetal development toxicity; AAALAC; Association for Assessment and Accreditation of Laboratory Animal Care; GD; gestation day; GLP; Good Laboratory Practice; ICH; International Conference on Har
Keywords: Hydroquinone; Dermal absorption; Permeation coefficients; Benchmark dose; Margin of exposure; Risk assessment; HQ; hydroquinone; i.v.; intravenous; LOAEL; lowest observed adverse effect level; AUC; area under curve; BMD; benchmark dose; BMDL; lower confid
Keywords: PCT; paracetamol; HPC; hydroperoxide content; LPX; lipid peroxidation; PCC; protein carbonyl content; SOD; superoxide dismutase; CAT; catalase; GPx; glutathione peroxidase; LC-MS/MS; liquid chromatography-tandem mass spectrometry; MS; mass spectrometer; L
Keywords: Windows of sensitivity; Motor development; Chemical exposures; Laboratory animals; GD; gestation day; LOAEL; lowest observed adverse effect level; NOAEL; no observed adverse effect level; PND; post-natal day; PNM; post-natal month; PNW; post-natal week;
Keywords: Allergy; Dose distribution; Modelling; Sesame; Threshold; DBPCFC; Double Blind Placebo Controlled Food Challenge test; ED; Eliciting Dose; EU; European Union; LOAEL; Lowest Observed Adverse Effect Level; NOAEL; No Observed Adverse Effect Level;
Keywords: CNS; central nervous system; CWM; Cincinnati water maze; DNT; developmental neurotoxicity; EOGRTS; extended one-generation reproductive toxicity study; EPA; Environmental Protection Agency; FOB; functional observational battery; L&M; learning and memory;
Keywords: AIC; Akaike information criterion; AP; abdominal pain; CI; confidence interval; DBPCFC; double-blind placebo-controlled food challenge; ED; eliciting dose; GI; gastrointestinal; OAS; oral allergy syndrome; LOAEL; the lowest observed adverse effect level;
Keywords: EDCs; endocrine disrupting chemicals; PCBs; polychlorinated biphenyls; PAHs; polyaromatic hydrocarbons; BFRs; brominated flame retardants; Aps; alkylphenols; PFCs; perfluorinated chemicals; POPs; persistent organic pollutants; ER; estrogen receptor; NOAEL
Keywords: AR; androgen receptor; BPH; benign prostatic hyperplasia; DBP; di-n-butyl phthalate; DHT; dihydrotestoterone; EDC; endocrine disrupting chemicals; ER; estrogen receptor; HDL; high density lipoproteins; IL-1β; interleukin-1β; LDL; low density lipoprotein
Keywords: As; arsenic; BMI; body mass index; BSID; Bayley Scales of Infant Development; Cal-EPA; California Environmental Protection Agency; CAT; Cognitive Abilities Test; CI; confidence interval; CVLTC; California Verbal Learning Test-Children; DMA; dimethylarseni
Keywords: AUC; area under the curve; BPA; bisphenol A; BUP; bitumen upgrading product; BR; bayrepel; CAP; trans-capsaicin; COM; complex organic mixture; CSO; clarified slurry oil; DAE; distillate aromatic extract; DDT; dichlorodiphenyltrichloroethane; DEET; N,N-Die
Keywords: ANOVA; one-way analysis of variance; bw; body weight; EGCG; epigallocatechin gallate; GTE; green tea extract; H&E; Hematoxylin & Eosin; IACUC; Institutional Animal Care and Use Committees; LD50; median lethal dose; LFP; lychee fruit extract; LOAEL; lowest
Keywords: BMD; benchmark dose; BMDL; lower confidence bound of the benchmark dose; NOAEL; no observed adverse effect level; LOAEL; lowest observed adverse effect level; EFSA; European Food Safety Authority; OECD; Organisation for Economic Co-operation and Developme
Keywords: DNEL; derived no effect level; ECHA; European Chemicals Agency; LD; lethal dose; LOAEL; lowest observed adverse effect level; MoS; margin of safety; NOAEL; no observed adverse effect level; REACH; registration, evaluation, authorization and restriction of
Keywords: DBPCFC; double-blind placebo-controlled food challenge; NOAEL; no observed adverse effect level; LOAEL; lowest observed adverse effect level; ED; eliciting dose; Threshold dose distribution; Simulation study; Allergenic foods;
Keywords: AGD; anogenital distance; BBP; butyl benzyl phthalate; CE; creatinine excretion; DBP; di-n-butyl phthalate; DEHP; di(2-ethylhexyl) phthalate; DEP; diethyl phthalate; DI; daily intake; DNEL; Derived No Effect Level; DiBP; diisobutyl phthalate; DiNP; diison
Keywords: C&L; Classification and Labelling; CLP; Classification and Labelling and Packaging Regulations; CMR; carcinogenicity, mutagenicity and reproductive toxicity; D/RT; developmental/reproductive toxicity; EC; European Community; ECETOC; European Centre for Ec
Keywords: ADD; average daily dose; COPC; contaminant of potential concern; CR; concentration ratio; EA; environmental assessment; EFW; energy-from-waste; EHQ; environmental hazard quotient; EPC; exposure point concentration; ERA; environmental risk assessment; HHRA
Keywords: NOAEL; no observed adverse effect level; LOAEL; lowest observed adverse effect level; fcan; daily feed consumption per animal; fcbw; daily feed consumption per bodyweight; Dose decrement; NOAEL; LOAEL; Study design; Pesticide toxicity;
Keywords: Allergenic foods; threshold dose distributions; children; eliciting dose; DBPCFC; Double-blind, placebo-controlled food challenge; ED; Eliciting dose; LOAEL; Lowest observed adverse effect level; NOAEL; No observed adverse effect level;
Keywords: AChE; acetyl cholinesterase; ARfD; acute reference dose; ADI; acceptable daily intake; AT; analytical threshold; BMDL; benchmark dose level; CAG; cumulative assessment group; CCFM; chemically complex food matrices; LOAEL; lowest observed adverse effect le
Keywords: DBPCFC; Double-blind, placebo-controlled oral food challenge; FAAN; Food Allergy & Anaphylaxis Network; FALCPA; Food Allergen Labeling and Consumer Protection Act; FDA; U.S. Food and Drug Administration; LOAEL; Lowest Observed Adverse Effect Level; NHANES
Keywords: 4-AMCH; 4-acetyl-1-methylcyclohexene; AF; assessment factor; DHC; dihydrocarvone; IPOH; 3-isopropenyl-6-oxo-heptanal; LOAEL; lowest-observed-adverse-effect-level; 6-MHO; 6-methyl-5-heptene-2-one; NOAEL; no-observed-adverse-effect-level; 4-OPA; 4-oxopentan
Keywords: Methyl methacrylate; Olfactory effects; Human relevance; Occupational levels; Physiologically based pharmacokinetic (PBPK) model; Dosimetric adjustment factors; 2-EH; 2-ethyl Hexanol; AA; acrylic acid; ACGIH; American Conference of Governmental Industrial
Keywords: ABC; ATP-binding cassette; ATR; atrazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)-s-triazine; AUC; area under the curve; BW; body weight; 14C-ATR; 14C-atrazine; DACT; didealkylatrazine, 2-chloro-4,6-diamino-1,3,5-triazine; DE; desethylatrazine, 2-chlor
Utilizing Threshold of Toxicological Concern (TTC) with high throughput exposure predictions (HTE) as a risk-based prioritization approach for thousands of chemicals
Keywords: AOPs; Adverse Outcome Pathways; FSANZ; Food Standards Australia New Zealand; HTE; High Throughput Exposure; HTS; high throughput screening; ILSI; International Life Sciences Institute; HESI; Health and Environmental Sciences Institute; RISK21; Risk Assess
A 90-day subchronic gavage toxicity study in Fischer 344 rats with 3-methylfuran
Keywords: 3-Methylfuran; Toxicology; LOAEL; NOAEL; Benchmark dose modelling;
Effects of bisphenol A and its analogs on reproductive health: A mini review
Keywords: 3β-HSD; 3β-hydroxysteroid dehydrogenase; AR; androgen receptor; BPA; bisphenol A; BPAF; bisphenol AF; BPF; bisphenol F; BPS; bisphenol S; CDC; the US Centers for Disease Control and Prevention; E2; estradiol; EC20; 20% maximal effect concentration; ER Î
Repeated dose 90-day oral toxicity test of G-7% NANA in rats: An application of new criterion for toxicity determination to test article-induced changes
Keywords: Glycomacropeptide; N-acetylneuraminic acid; NANA; Repeated dose,90-daytoxicity test; NOEL; NOAEL; LOAEL; Immunotoxicity; Toxicity determination criterion;
Use of physiologically based kinetic modelling-facilitated reverse dosimetry to convert in vitro cytotoxicity data to predicted in vivo liver toxicity of lasiocarpine and riddelliine in rat
Keywords: Physiologically based kinetic (PBK) model; Lasiocarpine; Riddelliine; Liver toxicity; In vitro-in vivo extrapolation; Reverse dosimetry; BMDL5-BMDU5; lower/upper limit of the 90% confidence interval of the benchmark dose that gives a 5% response; BMDL10;
Initial hazard assessment of 4-benzylphenol, a structural analog of bisphenol F: Genotoxicity tests in vitro and a 28-day repeated-dose toxicity study in rats
Keywords: CAS no. 101-53-1; 4-Benzylphenol; Genotoxicity; Repeated-dose toxicity; Rat; Gavage; NOAEL; D-value; Hazard class; Screening risk assessment; CHL; Chinese hamster lung fibroblastic cell; CSCL; The Japanese Chemical Substances Control Law; JECDB; Japan Exi
Cyanobacteria blooms in water: Italian guidelines to assess and manage the risk associated to bathing and recreational activities
Keywords: CB; cyanobacteria; CTX; cyanotoxins; CYN; cylindrospermopsin; MC; microcystin; ATX-a; anatoxin-a; LPS; lipopolysaccharides; STX; saxitoxins; NOAEL; No Observed Adverse Effect Level; LOAEL; Lowest Observed Adverse Effect Level; Cyanobacteria; Cyanotoxins;
Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop
Keywords: Regulatory toxicology; Transcriptomics; Metabolomics; Good laboratory practice (GLP); Weight-of-evidence (WoE); Adverse outcome pathway (AOP); Mode-of-action (MoA); Gene expression; Differentially expressed genes; ANOVA; Analysis of variance; AOP; Adverse
A generic Transcriptomics Reporting Framework (TRF) for 'omics data processing and analysis
Keywords: Regulatory toxicology; Normalisation of 'omics data; Statistical analysis; Differentially expressed genes; Reproducibility; Bioinformatics; Gene expression; ADI; Acceptable daily intake level; ANOVA; Analysis of variance; CEFIC; European Chemical Indust
The Monte Carlo technique as a tool to predict LOAEL
Keywords: QSAR; LOAEL; SMILES; Ecology; Drug toxicity; Optimal descriptor;
Micro-CT imaging: Developing criteria for examining fetal skeletons in regulatory developmental toxicology studies - A workshop report
Keywords: Concordance criteria; Developmental toxicology; Imaging; Micro-CT; Skeletal evaluation; GLP validation; 2-D; two-dimensional; 3-D; three-dimensional; CRO; contract research organization; DART; developmental and reproductive toxicology; EFD; embryo-fetal d
4-Week repeated dose oral toxicity study of N-ethyl-2-pyrrolidone in Sprague Dawley rats
Keywords: N-ethyl-2-pyrrolidone; Rat; 28-Day study; Toxicity; CYP 450; cytochrome P450; CYP 2E1; cytochrome P450 2E1; GGT; gamma glutamyl transferase; NEP; N-ethyl-2-pyrrolidone; NAG; N-acetyl glucosaminidase; LOAEL; lowest-observed-adverse-effect-level; NMP; N-met
Sperm quality and fertility in rats after prenatal exposure to low doses of TCDD: A three-generation study
Keywords: TCDD; Tetrachlorodibenzo-p-dioxin; GD; gestational day; LOAEL; lowest observed adverse effect level; LD50; median lethal dose; PND; post-natal day; Dioxin; Epididymis; Sperm quality; Fertility; Transgenerational effect;
Approaches for describing and communicating overall uncertainty in toxicity characterizations: U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) as a case study
Keywords: 4-VCH; 4-vinylcyclohexene; ARA; Alliance for Risk Assessment; ATSDR; Agency for Toxic Substances and Disease Registry; BEs; biomonitoring equivalents; BMD; benchmark dose; BMDL; benchmark dose lower confidence limit; CCl4; carbon tetrachloride; CDC; Cente
Predicting points of departure for risk assessment based on in vitro cytotoxicity data and physiologically based kinetic (PBK) modeling: The case of kidney toxicity induced by aristolochic acid I
Keywords: Physiologically based kinetic (PBK) model; Aristolochic acid I (AAI); Kidney toxicity; In vitro-in vivo extrapolation; Risk assessment; Physiologically based pharmacokinetic (PBPK) model; AA; aristolochic acid; AAI; aristolochic acid I; AAII; aristoloch
Peanut traces in packaged food products consumed by allergic individuals: Results of the MIRABEL project
Keywords: CTAB; cetyltrimethyl ammonium bromide; COV; coefficient of variation; DNA; desoxyribonucleic acid; ED; effective dose; ELISA; enzyme-linked immunosorbent assay; LFA; lateral flow assay; LOAEL; lowest observed adverse effect level; LOD; level of detection;
Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies)
Keywords: Ciguatera fish poisoning; Ciguatoxins; Mouse bioassay; Neuro-2A cell-based assay; LOAEL; Guadeloupe
NSAID-manufacturing plant effluent induces geno- and cytotoxicity in common carp (Cyprinus carpio)
Keywords: LOAEL; lowest observed adverse effect level; TUNEL; terminal deoxynucleotidyl transferase dUTP nick-end labeling; NSAID; nonsteroidal anti-inflammatory drug; ROS; reactive oxygen species; PAR; paracetamol; NPX; naproxen; DCF; diclofenac; IBP; ibuprofen; L
Impact of study design and database parameters on NOAEL distributions used for toxicological concern (TTC) values
Keywords: LOAEL; Lowest Observed Adverse Effect Level; NOAEL; No Observed Adverse Effect Level; PPP; Plant Protection Product, Active Ingredient; TTC; NOAEL; LOAEL; NOAEL distribution;