کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8550984 | 1562106 | 2018 | 53 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Initial hazard assessment of 4-benzylphenol, a structural analog of bisphenol F: Genotoxicity tests in vitro and a 28-day repeated-dose toxicity study in rats
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کلمات کلیدی
CsClChlOECDMHLWLOAELNOAELD-value - ارزش DQSAR - بزرگسال Quantitative structure-activity relationship - رابطه ساختاری و فعالیت کمیOrganization for Economic Cooperation and Development - سازمان همکاری های اقتصادی و توسعهRepeated-dose toxicity - سمیت دوزهای مجزاGenotoxicity - سمیت ژنتیکیUncertainty factor - عدم قطعیتRat - موش صحراییNo observed adverse effect level - هیچ عوارض جانبی مشاهده نشدهLowest observed adverse effect level - کمترین میزان بروز ناخواسته مشاهده شدهGavage - گاواژ
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
4-Benzylphenol (CAS No. 101-53-1), a structural analog of bisphenol F, has estrogenic activity in vitro and in vivo, as is the case with bisphenol F. 4-Benzylphenol is used in plastics and during organic synthesis. Since its safety is largely unknown, we conducted toxicity tests as part of screening risk assessment in an existing chemical safety survey program. Based on results of the Ames test and the chromosomal aberration test using Chinese hamster lung cells (OECD TG 471 and 473), 4-benzylphenol was determined to be non-genotoxic in vitro. In a 28-day repeated-dose toxicity study, Crl:CD (SD) rats were administrated 4-benzylphenol by gavage at 0, 30, 150, or 750â¯mg/kg/day (OECD TG 407). Consequently, body weight was lower in males at 750â¯mg/kg/day. In the liver, relative organ weights were increased in both sexes at 750â¯mg/kg/day, and centrilobular hepatocellular hypertrophy was observed in males at 150 and 750â¯mg/kg/day. In the forestomach, hyperkeratosis and hyperplasia of squamous cells were observed in males at 150 and 750â¯mg/kg/day, and in females at 750â¯mg/kg/day. Based on these results, we identified the NOAEL for 4-benzylphenol as 30â¯mg/kg/day, with a hazard assessment value (D-value) of 0.05â¯mg/kg/day corresponding to hazard class 3.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 96, July 2018, Pages 64-75
Journal: Regulatory Toxicology and Pharmacology - Volume 96, July 2018, Pages 64-75
نویسندگان
Toshime Igarashi, Hideki Serizawa, Katsumi Kobayashi, Hiroshi Suzuki, Mariko Matsumoto, Takako Iso, Tomoko Kawamura, Kaoru Inoue, Atsushi Ono, Takashi Yamada, Akihiko Hirose,