Keywords: کمترین میزان بروز ناخواسته مشاهده شده; NOAEL; no observed adverse effect level; LOAEL; lowest observed adverse effect level; MRL; minimal risk level; JECFA; joint expert committee on food additives; ATSDR; agency for toxic substances and disease registry; PTWI; provisional tolerable weekly int
مقالات ISI کمترین میزان بروز ناخواسته مشاهده شده (ترجمه نشده)
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Keywords: کمترین میزان بروز ناخواسته مشاهده شده; β-HCH; β-hexachlorocyclohexane; µg/l; microgram per liter; µM/l; micromolar per liter; Æ©; total; 1-HP; 1-hydroxypyrene; 2; 3-DHBA, 2,3-dihydroxybenzoic Acid; 2cx-MMHP; mono-(2-carboxymethylhexyl) phthalate; 3PBA; 3-phenoxybenzoic acid; 4F3PBA; 4-fluo
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; ADME; Absorption, Distribution, Metabolism, Excretion; AOPs; adverse outcome pathways; AUC; Area under the Curve; AEs; assessment elements; AOs; assessment options; BMDL; benchmark dose lower bound; CAAT; Center for Alternatives to Animal Testing; Cefic-L
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; Food allergy; Walnut; Allergen thresholds; Threshold dose distributions; Eliciting doses; DBPCFC; Double-blind, placebo-controlled food challenge; ED; Eliciting doses; ICSA; Interval-Censoring Survival Analysis; LOAEL; Lowest observed adverse effect level
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; Hydroquinone; Dermal absorption; Permeation coefficients; Benchmark dose; Margin of exposure; Risk assessment; HQ; hydroquinone; i.v.; intravenous; LOAEL; lowest observed adverse effect level; AUC; area under curve; BMD; benchmark dose; BMDL; lower confid
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; PCT; paracetamol; HPC; hydroperoxide content; LPX; lipid peroxidation; PCC; protein carbonyl content; SOD; superoxide dismutase; CAT; catalase; GPx; glutathione peroxidase; LC-MS/MS; liquid chromatography-tandem mass spectrometry; MS; mass spectrometer; L
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; Windows of sensitivity; Motor development; Chemical exposures; Laboratory animals; GD; gestation day; LOAEL; lowest observed adverse effect level; NOAEL; no observed adverse effect level; PND; post-natal day; PNM; post-natal month; PNW; post-natal week;
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; Allergy; Dose distribution; Modelling; Sesame; Threshold; DBPCFC; Double Blind Placebo Controlled Food Challenge test; ED; Eliciting Dose; EU; European Union; LOAEL; Lowest Observed Adverse Effect Level; NOAEL; No Observed Adverse Effect Level;
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; CNS; central nervous system; CWM; Cincinnati water maze; DNT; developmental neurotoxicity; EOGRTS; extended one-generation reproductive toxicity study; EPA; Environmental Protection Agency; FOB; functional observational battery; L&M; learning and memory;
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; EDCs; endocrine disrupting chemicals; PCBs; polychlorinated biphenyls; PAHs; polyaromatic hydrocarbons; BFRs; brominated flame retardants; Aps; alkylphenols; PFCs; perfluorinated chemicals; POPs; persistent organic pollutants; ER; estrogen receptor; NOAEL
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; AR; androgen receptor; BPH; benign prostatic hyperplasia; DBP; di-n-butyl phthalate; DHT; dihydrotestoterone; EDC; endocrine disrupting chemicals; ER; estrogen receptor; HDL; high density lipoproteins; IL-1β; interleukin-1β; LDL; low density lipoprotein
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; AUC; area under the curve; BPA; bisphenol A; BUP; bitumen upgrading product; BR; bayrepel; CAP; trans-capsaicin; COM; complex organic mixture; CSO; clarified slurry oil; DAE; distillate aromatic extract; DDT; dichlorodiphenyltrichloroethane; DEET; N,N-Die
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; BMD; benchmark dose; BMDL; lower confidence bound of the benchmark dose; NOAEL; no observed adverse effect level; LOAEL; lowest observed adverse effect level; EFSA; European Food Safety Authority; OECD; Organisation for Economic Co-operation and Developme
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; DNEL; derived no effect level; ECHA; European Chemicals Agency; LD; lethal dose; LOAEL; lowest observed adverse effect level; MoS; margin of safety; NOAEL; no observed adverse effect level; REACH; registration, evaluation, authorization and restriction of
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; DBPCFC; double-blind placebo-controlled food challenge; NOAEL; no observed adverse effect level; LOAEL; lowest observed adverse effect level; ED; eliciting dose; Threshold dose distribution; Simulation study; Allergenic foods;
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; AGD; anogenital distance; BBP; butyl benzyl phthalate; CE; creatinine excretion; DBP; di-n-butyl phthalate; DEHP; di(2-ethylhexyl) phthalate; DEP; diethyl phthalate; DI; daily intake; DNEL; Derived No Effect Level; DiBP; diisobutyl phthalate; DiNP; diison
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; NOAEL; no observed adverse effect level; LOAEL; lowest observed adverse effect level; fcan; daily feed consumption per animal; fcbw; daily feed consumption per bodyweight; Dose decrement; NOAEL; LOAEL; Study design; Pesticide toxicity;
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; Allergenic foods; threshold dose distributions; children; eliciting dose; DBPCFC; Double-blind, placebo-controlled food challenge; ED; Eliciting dose; LOAEL; Lowest observed adverse effect level; NOAEL; No observed adverse effect level;
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; DBPCFC; Double-blind, placebo-controlled oral food challenge; FAAN; Food Allergy & Anaphylaxis Network; FALCPA; Food Allergen Labeling and Consumer Protection Act; FDA; U.S. Food and Drug Administration; LOAEL; Lowest Observed Adverse Effect Level; NHANES
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; Methyl methacrylate; Olfactory effects; Human relevance; Occupational levels; Physiologically based pharmacokinetic (PBPK) model; Dosimetric adjustment factors; 2-EH; 2-ethyl Hexanol; AA; acrylic acid; ACGIH; American Conference of Governmental Industrial
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; ABC; ATP-binding cassette; ATR; atrazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)-s-triazine; AUC; area under the curve; BW; body weight; 14C-ATR; 14C-atrazine; DACT; didealkylatrazine, 2-chloro-4,6-diamino-1,3,5-triazine; DE; desethylatrazine, 2-chlor
Use of physiologically based kinetic modelling-facilitated reverse dosimetry to convert in vitro cytotoxicity data to predicted in vivo liver toxicity of lasiocarpine and riddelliine in rat
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; Physiologically based kinetic (PBK) model; Lasiocarpine; Riddelliine; Liver toxicity; In vitro-in vivo extrapolation; Reverse dosimetry; BMDL5-BMDU5; lower/upper limit of the 90% confidence interval of the benchmark dose that gives a 5% response; BMDL10;
Initial hazard assessment of 4-benzylphenol, a structural analog of bisphenol F: Genotoxicity tests in vitro and a 28-day repeated-dose toxicity study in rats
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; CAS no. 101-53-1; 4-Benzylphenol; Genotoxicity; Repeated-dose toxicity; Rat; Gavage; NOAEL; D-value; Hazard class; Screening risk assessment; CHL; Chinese hamster lung fibroblastic cell; CSCL; The Japanese Chemical Substances Control Law; JECDB; Japan Exi
Cyanobacteria blooms in water: Italian guidelines to assess and manage the risk associated to bathing and recreational activities
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; CB; cyanobacteria; CTX; cyanotoxins; CYN; cylindrospermopsin; MC; microcystin; ATX-a; anatoxin-a; LPS; lipopolysaccharides; STX; saxitoxins; NOAEL; No Observed Adverse Effect Level; LOAEL; Lowest Observed Adverse Effect Level; Cyanobacteria; Cyanotoxins;
Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; Regulatory toxicology; Transcriptomics; Metabolomics; Good laboratory practice (GLP); Weight-of-evidence (WoE); Adverse outcome pathway (AOP); Mode-of-action (MoA); Gene expression; Differentially expressed genes; ANOVA; Analysis of variance; AOP; Adverse
A generic Transcriptomics Reporting Framework (TRF) for 'omics data processing and analysis
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; Regulatory toxicology; Normalisation of 'omics data; Statistical analysis; Differentially expressed genes; Reproducibility; Bioinformatics; Gene expression; ADI; Acceptable daily intake level; ANOVA; Analysis of variance; CEFIC; European Chemical Indust
Sperm quality and fertility in rats after prenatal exposure to low doses of TCDD: A three-generation study
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; TCDD; Tetrachlorodibenzo-p-dioxin; GD; gestational day; LOAEL; lowest observed adverse effect level; LD50; median lethal dose; PND; post-natal day; Dioxin; Epididymis; Sperm quality; Fertility; Transgenerational effect;
Predicting points of departure for risk assessment based on in vitro cytotoxicity data and physiologically based kinetic (PBK) modeling: The case of kidney toxicity induced by aristolochic acid I
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; Physiologically based kinetic (PBK) model; Aristolochic acid I (AAI); Kidney toxicity; In vitro-in vivo extrapolation; Risk assessment; Physiologically based pharmacokinetic (PBPK) model; AA; aristolochic acid; AAI; aristolochic acid I; AAII; aristoloch
Peanut traces in packaged food products consumed by allergic individuals: Results of the MIRABEL project
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; CTAB; cetyltrimethyl ammonium bromide; COV; coefficient of variation; DNA; desoxyribonucleic acid; ED; effective dose; ELISA; enzyme-linked immunosorbent assay; LFA; lateral flow assay; LOAEL; lowest observed adverse effect level; LOD; level of detection;
Impact of study design and database parameters on NOAEL distributions used for toxicological concern (TTC) values
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; LOAEL; Lowest Observed Adverse Effect Level; NOAEL; No Observed Adverse Effect Level; PPP; Plant Protection Product, Active Ingredient; TTC; NOAEL; LOAEL; NOAEL distribution;
NSAID-manufacturing plant effluent induces geno- and cytotoxicity in common carp (Cyprinus carpio)
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; LOAEL; lowest observed adverse effect level; TUNEL; terminal deoxynucleotidyl transferase dUTP nick-end labeling; NSAID; nonsteroidal anti-inflammatory drug; ROS; reactive oxygen species; PAR; paracetamol; NPX; naproxen; DCF; diclofenac; IBP; ibuprofen; L
Examining the feasibility of mixture risk assessment: A case study using a tiered approach with data of 67 pesticides from the Joint FAO/WHO Meeting on Pesticide Residues (JMPR)
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; Mixture toxicology; Mixture risk assessment; Dose addition; Hazard index; Pesticide; JMPR; ADI; acceptable daily intake; AL; acceptable level; CAG; cumulative assessment group; EL; exposure level; GAP; good agricultural practice; GEMS; Global Environment
EPHECT III: Health risk assessment of exposure to household consumer products
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; AF; assessment factor; CEL; critical exposure limit; HK; housekeepers; HRA; health risk assessment; IAQ; indoor air quality; IAQG; indoor air quality guideline; LOAEL; lowest observed adverse effect level; ME; microenvironment; NOAEL; no observed adverse
Use of read-across and computer-based predictive analysis for the safety assessment of PEG cocamines
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; CIR; Cosmetic Ingredient Review; GD; gestation day; LOAEL; lowest observed adverse effect level; NOAEL; no observed adverse effect level; NOEL; no observed effect level; PEG; polyethylene glycol; SAR; structure-activity relationship; SOI; structure of i
Management of contaminated marine marketable resources after oil and HNS spills in Europe
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; Oil spill; Contaminated seafood; Hazardous and noxious substances (HNS); Risk assessment; Lift fishery bans; Decision criteria; ALARA; as low as reasonably achievable; B[a]P; Benzo[a]pyrene; BaPE; Benzo[a]pyrene equivalents; BMDL10; benchmark lower limit
Dietary exposure of juvenile female mice to polyhalogenated seafood contaminants (HBCD, BDE-47, PCB-153, TCDD): Comparative assessment of effects in potential target tissues
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; BDE-47; 2,2â²4,4â² Tetrabromodiphenyl ether; BFR; brominated flame retardants; Bw; body weight; DMSO; dimethylsulfoxide; E2; 17-beta estradiol; EU; European Union; HBCD; hexabromocyclododecane; LOAEL; Lowest Observed Adverse Effect Level; NDL; non dioxi
Relative parameter sensitivity in prenatal toxicity studies with substances classified as developmental toxicants
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; Developmental toxicity; Risk assessment; Lowest Observed Adverse Effect Level; Classification and Labeling
A regulatory approach to assess the potency of substances toxic to the reproduction
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; GHS; globally harmonised system of classification and labelling of chemicals; CLP; regulation on classification labelling and packaging of substances and mixtures; GCL; generic concentration limit; SCL; specific concentration limit; LOAEL; lowest observed
Risk assessment of endocrine active chemicals: Identifying chemicals of regulatory concern
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; ACR; acute-to-chronic ratio; BfR; Bundesinstitut für Risikobewertung (German regulatory body); CLP; Classification, Labelling and Packaging; CRD; Chemicals Regulation Directorate (UK regulatory body); ECETOC; European Centre for Ecotoxicology and Toxicol
A consistent and transparent approach for calculation of Derived No-Effect Levels (DNELs) for petroleum substances
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; ACGIH; American Conference of Governmental Industrial Hygienists; AD; Animal Dose; AF; Assessment Factor; BW; body weight; CLP; Classification, Labelling and Packaging Regulation; CNS; Central Nervous System; CSA; Chemical Safety Assessment; CSR; Chemical
Prenatal exposure to bisphenol A promotes angiogenesis and alters steroid-mediated responses in the mammary glands of cycling rats
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; BPA; bisphenol A; CV; coefficients of variation; DAPI; 4â²,6-diamidino-2-phenylindole dihydrochloride; E2; 17β-estradiol; EPA; Environmental Protection Agency; ER; estrogen receptor; FSH; follicle stimulating hormone; GD; gestation day; H&E; hematoxylin
A novel application of the Margin of Exposure approach: Segregation of tobacco smoke toxicants
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; AIC; Akaike's information criteria; ALARA; as low as reasonably achievable; B(a)P; benzo(a)pyrene; BMD; benchmark dose; BMDL and BMDL10; benchmark dose lower confidence limit; BMDS; Benchmark Dose Software; BMR; benchmark response; CalEPA; Californian E
Exposure based waiving: The application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; TTC; threshold of toxicological concern; EBW; exposure based waiving; REACH TGD; Registration Evaluation and Authorisation of Chemicals Technical Guidance Document; NOAEL; no observed adverse effect level; NOAEC; no observed adverse effect concentration;
Evaluation of biochemical effects related to perfluorooctane sulfonic acid exposure in organohalogen-contaminated great tit (Parus major) and blue tit (Parus caeruleus) nestlings
Keywords: کمترین میزان بروز ناخواسته مشاهده شده; PFOS; perfluorooctane sulfonic acid; ww; wet weight; ALT; alanine aminotransferase; OCP; organochlorine pesticide; PCB; polychlorinated biphenyl; PBDE; polybrominated biphenyl ether; HCH; hexachlorocyclohexane; HCB; hexachlorobenzene; OxC; oxychlordane; T