A regulatory approach to assess the potency of substances toxic to the reproduction

► The reproductive toxicity potency range of substances in the database is approximately one million. ► The average potency distribution of substances classified in category 1 versus category 2 was similar. ► The distributions show a clear log-normal distribution which will allow the setting of boundaries for the setting of SCLs. ► The ED10 for effects warranting classification is proposed as the best parameter for the potency.