کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5856668 | 1131980 | 2015 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Use of read-across and computer-based predictive analysis for the safety assessment of PEG cocamines
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کلمات کلیدی
SARSOIUDSCIRLOAELNOELNOAELSafety assessment - ارزیابی ایمنیRead-Across - خواندن در سراسرStructure–activity relationship - رابطه ساختار-فعالیتStructure activity relationship (SAR) - رابطه فعالیت ساختاری (SAR)gestation day - روز بارداریUnscheduled DNA synthesis - سنتز DNA بدون برنامه ریزی شدهCosmetics - لوازم آرایشیNo observed effect level - هیچ سطح اثر مشاهده شدهNo observed adverse effect level - هیچ عوارض جانبی مشاهده نشدهpolyethylene glycol - پلی اتیلن گلیکولPEG - پلیاتیلن گلیکول Lowest observed adverse effect level - کمترین میزان بروز ناخواسته مشاهده شده
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Use of read-across and computer-based predictive analysis for the safety assessment of PEG cocamines Use of read-across and computer-based predictive analysis for the safety assessment of PEG cocamines](/preview/png/5856668.png)
چکیده انگلیسی
In the European Union animal testing has been eliminated for cosmetic ingredients while the US Cosmetic Ingredient Review Expert Panel may request data from animal studies. The use of read-across and predictive toxicology provides a path for filling data gaps without additional animal testing. The PEG cocamines are tertiary amines with an alkyl group derived from coconut fatty acids and two PEG chains of varying length. Toxicology data gaps for the PEG cocamines can be addressed by read-across based on structure-activity relationship using the framework described by Wu et al. (2010) for identifying suitable structural analogs. Data for structural analogs supports the conclusion that the PEG cocamines are non-genotoxic and not expected to exhibit systemic or developmental/reproductive toxicity with use in cosmetics. Due to lack of reliable dermal sensitization data for suitable analogs, this endpoint was addressed using predictive software (TIMES SS) as a first step (Laboratory of Mathematical Chemistry). The prediction for PEG cocamines was the same as that for PEGs, which have been concluded to not present a significant concern for dermal sensitization. This evaluation for PEG cocamines demonstrates the utility of read-across and predictive toxicology tools to assess the safety of cosmetic ingredients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 71, Issue 3, April 2015, Pages 515-528
Journal: Regulatory Toxicology and Pharmacology - Volume 71, Issue 3, April 2015, Pages 515-528
نویسندگان
Julie A. Skare, Karen Blackburn, Shengde Wu, Thomas A. Re, Daniel Duche, Stephanie Ringeissen, Donald L. Bjerke, Viny Srinivasan, Carol Eisenmann,