Keywords: salt; solubility; stability; biopharmaceutical; poorly water soluble; solution phase; solid phase; equilibrium; pKa; pH; AB; acetate buffer; ACN; acetonitrile; API; active pharmaceutical ingredient; BS; benzoate salt; CB; citrate buffer; DSC; differential
مقالات ISI (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
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Keywords: Pyrrolizidine alkaloids; Acute toxicants; Genotoxic carcinogens; Hepatotoxic agents; Food; Food supplements; ANZFA; Australia New Zealand Food Authority; acute reference dose; ARfD; DHP; 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5[[H]]-pyrrolizine; BfR; Feder
Keywords: Caffeine; Systematic review; Safety; Pregnancy; Coffee; Behavior; ADHD; attention deficit hyperactivity disorder; AHRQ; Agency for Healthcare Research and Quality; BMC; bone mineral content; BMD; bone mineral density; BMI; body mass index; CDC; US Centers
Keywords: MN; micronucleus; CA; chromosomal aberrations; CBMN; cytokinesis-block micronucleus assay; GSH; glutathione; IARC; International Agency for Research on Cancer; i.p.; intraperitonelly; LOEL; lowest observed effect level; MTD; maximum tolerated dose; NOEL;
Keywords: ACD; Allergic Contact Dermatitis; AEL; Acceptable Exposure Level; AF; assessment factor; AOO; acetone-olive oil; CEE; categorical exposure estimate; CEL; Consumer Exposure Level; CES; carboxylesterases; CSAF; Chemical-Specific Adjustment Factors; DDEF; Da
Keywords: FeDTex database; Reproductive toxicology; LOEL; NOEL; Risk assessment; Multi-generation reproductive toxicity study;
Keywords: 2D-GC; 2-dimensional gas chromatography, or GCÂ ÃÂ GC; CLP; classification, labelling and packaging of substances and mixtures (Regulation (EC) No. 1272/2008); C-range; carbon range; CSR; Chemical Safety Report; CONCAWE; Conservation of Clean Air and Wat
Keywords: ADE; acceptable daily exposure; EMA; European Medicines Agency; ICH; International Conference on Harmonisation; ISPE; International Society of Pharmaceutical Engineers; MAC; maximum allowable carryover; MRTD; maximum recommended therapeutic dose; NOEL; no
Less-toxic rearrangement products of NX-toxins are formed during storage and food processing
Keywords: DAS; diacetoxyscirpenol; DMEM; Dulbecco's Modified Eagle's Medium; DON; deoxynivalenol; ELSD; evaporative light scattering detector; HRMS; high resolution mass spectrometry; MeOH; methanol; MS/MS; tandem mass spectrometry; NOEL; no observed effect lev
Study on the developmental toxicity of β-ionone in the rat
Keywords: Embryotoxicity; Food additives; Fragrance chemicals; Reproductive toxicity; Teratogenicity; ADI; acceptable daily intake; BIO; β-ionone; CYP; cytochrome P450; FDA; US Food and Drug Administration; GD; gestation day; γ-GT; γ-glutamyltransferase; GRAS; G
Repeated dose 90-day oral toxicity test of G-7% NANA in rats: An application of new criterion for toxicity determination to test article-induced changes
Keywords: Glycomacropeptide; N-acetylneuraminic acid; NANA; Repeated dose,90-daytoxicity test; NOEL; NOAEL; LOAEL; Immunotoxicity; Toxicity determination criterion;
Effects of daily exposure to saccharin sodium and rebaudioside A on the ovarian cycle and steroidogenesis in rats
Keywords: T1R3; taste receptor type 1 subunit 3; Gα; G protein α-gustducin; T2R38; taste receptor type 2 subunit 38; GPCR; G-protein coupled receptors; PLC-β2; phospholipase C-β2; cAMP; cyclic adenosine monophosphate; FSH; follicle-stimulating hormone; LH; lute
Advances on the chromatographic determination of amphenicols in food
Keywords: ADI; Acceptable Daily Intake; APPI; Atmospheric pressure photoionization; CAP; chloramphenicol; CAP-Glu; Chloramphenicol glucuronide; CCα; Decision limit; CCβ; Capacity of detection; CVM; Center for Veterinary Medicine; DAD; Diode array detector; ECD; E
Suitability of the in vitro Caco-2 assay to predict the oral absorption of aromatic amine hair dyes
Keywords: AEP; 2-amino-5-ethylphenol; CEN; 2-chloro-6-ethylamino-4-nitrophenol; HAP; 4-hydroxypropylamino-3-nitrophenol; APB; HC Blue 16; HCR; HC Red no 13; HCY; HC Yellow no 13; HDAP; 1-hydroxyethyl-4,5-diamino pyrazole; ACP; 2-amino-6-chloro-4-nitrophenol; AHT; 4
FEMA expert panel review of p-mentha-1,8-dien-7-al genotoxicity testing results
Keywords: Perilla; Perillaldehyde; Flavoring ingredients; Genotoxicity; FEMA GRAS; bw; body weight; CA; chromosomal aberration; EMS; ethylmethanesulfonate; EFSA; the European Food Safety Authority; FEMA; the Flavor and Extract Manufacturers Association; GLP; good l
A two-year dietary carcinogenicity study of (2R,4R)-monatin salt in mice
Keywords: Carcinogenicity; R,R-Monatin; Mice; Safety; Dietary; AAALAC; Association for Assessment and Accreditation of Laboratory Animal Care; ADME; absorption, distribution, metabolism and excretion; ALT; alanine aminotransferase; FDA; US Food and Drug Administrat
Safety evaluation of rebaudioside A produced by fermentation
Keywords: Rebaudioside A; Yarrowia lipolytica; Steviol glycosides; Fermentative; Safety evaluation; ADI; Acceptable Daily Intake; EFSA; European Food Safety Authority; FCC; Food Chemical Codex; FDA; Food and Drug Administration; JECFA; Joint FAO/WHO Expert Committe
Acute and subacute toxicity studies of CMICE-013, a novel iodinated rotenone-based myocardial perfusion tracer, in Sprague Dawley rats and Gottingen minipigs
Keywords: Preclinical toxicity study; CMICE-013; Myocardial perfusion tracer; Iodinated rotenone; MPI; myocardial perfusion imaging; RBC; red blood cell; HGB; hemoglobin; HCT; hematocrit; MCV; mean corpuscular volume; MCH; mean corpuscular hemoglobin; MCHC; mean co
A combined dietary chronic toxicity and two-year carcinogenicity study of (2R,4R)-monatin salt in Sprague-Dawley rats
Keywords: Carcinogenicity; Chronic; Rat; Safety; Dietary; (2R,4R)-Monatin; AAALAC; Association for Assessment and Accreditation of Laboratory Animal Care; ADME; absorption, distribution, metabolism and excretion; FDA; US Food and Drug Administration; GLP; Good Labo
Genotoxic properties of representatives of alkylindazoles and aminoalkyl-indoles which are consumed as synthetic cannabinoids
Keywords: Synthetic cannabinoids; Genotoxicity; Comet assay; Micronucleus; Lymphocytes; 2-AA; 2-aminoanthracene; BN-MN; binucleated cells with micronucleus; CBMN assay; cytokinesis-block micronucleus assay; MN; micronucleus; Nbuds; nuclear buds; CBPI; cytokinesis-b
Global histone modifications in Fumonisin B1 exposure in rat kidney epithelial cells
Keywords: FB1; Fumonisin B1; HAT; histone acetyltransferase; H3K9ac; histone H3 lysine 9 acetylation; H3K9me2; histone H3 lysine 9 dimethylation; H3K9me3; histone H3 lysine 9 trimethylation; H3K4me3; histone H3 lysine 4 trimethylation; H4K20me3; histone H4 lysine 2
A reproductive, developmental and neurobehavioral study following oral exposure of tetrabromobisphenol A on Sprague-Dawley rats
Keywords: Tetrabromobisphenol A; Reproductive/developmental effects; Oral exposure; NOEL;
Use of read-across and computer-based predictive analysis for the safety assessment of PEG cocamines
Keywords: CIR; Cosmetic Ingredient Review; GD; gestation day; LOAEL; lowest observed adverse effect level; NOAEL; no observed adverse effect level; NOEL; no observed effect level; PEG; polyethylene glycol; SAR; structure-activity relationship; SOI; structure of i
Foodborne mycotoxicoses, risk assessment and underestimated hazard of masked mycotoxins and joint mycotoxin effects or interaction
Keywords: ALARA; As Low As Reasonably Achievable; BEN; Balkan Endemic Nephropathy; CAC; Codex Alimentarius Commission; CCFAC; Codex Committee on Food Additives and Contaminants; DALY; Disability Adjustment Life Year; DAS; Diacetoxyscirpenol; DON; Deoxynivalenol; EU
14th Annual Meeting of the Safety Pharmacology Society: Threading through peripheral and central nervous system presentations
Keywords: Aβ; Aβ-amyloid protein; AANEM; American Academy of Neuromuscular and Electrodiagnostic Medicine; AAN; American Academy of Neurology; AD; Alzheimer's Disease; API; Alzheimer's Prevention Initiative-APOE4; ADF; Abuse Deterrent Formulations; ADNI; Alzheime
Effect of atrazine and fenitrothion at no-observed-effect-levels (NOEL) on amphibian and mammalian corticosterone-binding-globulin (CBG)
Keywords: NOEL; Atrazine; Fenitrothion; CBG; Amphibian; Rat;
Evaluations of the mutagenicity of a pigment extract from bulb culture of Hippeastrum reticulatum
Keywords: ADI; acceptable daily intake; AF2; 2-2(2-furyl)-3-(5-nitro-2-furyl) acrylamide; BAP; 6-benzylaminopurine; BP5; benzo(a)pyrene; CB; chromosome break; DEL; deletion; DBMA; dimethylbenz(a)anthracine; DMFA; dimethylformamide; FDA; food and drug administration
The JFFMA assessment of flavoring substances structurally related to menthol and uniquely used in Japan
Keywords: ADI; acceptable daily intake; EFSA; European Food Safety Authority; FEMA; Flavor and Extract Manufacturers Association; MSDI; Maximized Survey-Derived Intake; NOEL; no observed effect level; JECFA; Joint FAO/WHO Expert Committee on Food Additives; JFFMA;
Estimates of daily di-isodecyl phthalate (DIDP) intake calculated from urinary biomonitoring data
Keywords: ADI; acceptable daily intake; CE; creatinine excretion rate; DINP; di-isononyl phthalate; DIDP; di-isodecyl phthalate; DPHP; di-propyl-heptyl phthalate; FUE; fractional urinary excretion; MIDP; mono-isodecyl phthalate; MINP; mono-isononyl phthalate; OH-MI
Thujone and thujone-containing herbal medicinal and botanical products: Toxicological assessment
Keywords: Thujone; Risk assessment; Toxicity; Metabolism; Pharmacokinetics; ADI; acceptable daily intake; BMDL; benchmark dose (lower confidence limit); CNS; central nerve system; CYP; cytochrome P450; EMA; European Medicines Agency; GABAA; gamma-aminobutyric acid
Trigger values for investigation of hormonal activity in drinking water and its sources using CALUX bioassays
Keywords: ADI; Acceptable Daily Intake; ADME; Absorption, Distribution, Metabolism, Excretion; AR; Androgen Receptor; BQ; Benchmark Quotient; DEX; Dexamethasone; DHT; Dihydrotestosterone; DMSO; Dimethylsulfoxide; E1; Estrone; E2; 17β-Estradiol; EE2; 17α-Ethinyles
Toxicological evaluation of peroxy sulfonated oleic acid (PSOA) in subacute and developmental toxicity studies
Keywords: Peroxy sulfonated oleic acid; PSOA; Subacute toxicity; Developmental toxicity; Hydroperoxide; NOEL;
Safety assessment of a new multivitamin
Keywords: A/G; albumin to globulin ratio; ALB; albumin; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BUN; blood urea nitrogen; BW; body weight; CHOL; cholesterol; CI; confidence interval; CR; creatinine; GLB; globulin; GLU; glucose; HCT; haemocri
Airway effects of repeated exposures to ozone-initiated limonene oxidation products as model of indoor air mixtures
Keywords: BAL; bronchoalveolar lavage; f; breaths per min; LOP; limonene oxidation products; NOEL; no-observed-effect-level; TB; time of break; TI; time of inspiration; TP; duration of the pause between end of expiration and the initiation of the next inhalation; V
Safety evaluation of a natural eggshell membrane-derived product
Keywords: AAFCO; Association of American Feed Control Officials; ABSRET; absolute reticulocytes; A/G; albumin/globulin ratio; ALB; albumin; ALP; alkaline phosphatase; ALT; alanine aminotransferase; ANOVA; analysis of variance; APTT; activated partial thromboplastin
Prediction of skin sensitization potency of chemicals by human Cell Line Activation Test (h-CLAT) and an attempt at classifying skin sensitization potency
Keywords: h-CLAT; human Cell Line Activation Test (h-CLAT); EC3; estimated concentration that produces a stimulation index of 3 in the murine local lymph node assay; LLNA; murine local lymph node assay; CV75; tested concentration providing a cell viability of 75%;
Risk assessment for consumer exposure to toluene diisocyanate (TDI) derived from polyurethane flexible foam
Keywords: BHR; bronchial hyperreactivity; BMDS; USEPA benchmark dose software; CSF; cancer slope factor; FEV; forced expiratory volume; FEV1; forced expiratory volume in one second; FVC; forced vital capacity; GPMT; guinea pig maximization test; LADD; lifetime aver
Fumonisin B1 and the kidney: Modes of action for renal tumor formation by fumonisin B1 in rodents
Keywords: AP; aminopentol; aSMase; acid sphingomyelinase; FB1; fumonisin B1; JNK; c-Jun N-terminal kinase; CYP; cytochrome P450 superfamiliy; ERK; extracellular regulated kinase; GCS; glucosylceramide synthase; GSH; glutathione; HFB1; hydrolyzed FB1; MAPK; mitogen-
Risk assessment of genotoxic mutagens with thresholds: A brief introduction
Keywords: Genotoxin; Threshold; Risk-assessment; Mutagen; NOEL; NOAEL; Carcinogen;
Subchronic inhalation of mixtures of cigarette smoke constituents in Xpaâ/âp53+/â knock-out mice: A comparison of intermittent with semi-continuous exposure to acetaldehyde, formaldehyde, and acrolein
Keywords: ANOVA; analysis of variance; B[a]P; benzo[a]pyrene; SC; semi-continuous exposure to a mixture of acetaldehyde, formaldehyde and acrolein; IE; intermittent exposure to a mixture of acetaldehyde, formaldehyde and acrolein; KO; knock-out; MV; mean tidal volu
The FEMA GRAS assessment of α,β-unsaturated aldehydes and related substances used as flavor ingredients
Keywords: ABS; chromosomal aberrations; ADH; alcohol dehydrogenase; ALDH; aldehyde dehydrogenase; BSA; bovine serum albumin; dG; deoxyguanosine; FEMA; Flavor and Extract Manufacturers Association; FPG; formamidopyrimidine DNA glycosylase; GRAS; generally recognized
Relationship between dose of emamectin benzoate and molting response of ovigerous American lobsters (Homarus americanus)
Keywords: Homarus; American lobster; Emamectin benzoate; SLICE™; Molt; NOEL
Existence of no-observed effect levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline on hepatic preneoplastic lesion development in BN rats
Keywords: 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline; Cancer risk assessment; Hepatocarcinogenesis; No-observed effect level; Strain differences; 2-AFF; 2-acetylaminofluorene; DEN; diethylnirtrosamine; GST-P; glutathione S-transferase placental form; MeIQx; 2-am
REPDOSE: A database on repeated dose toxicity studies of commercial chemicals—A multifunctional tool
Keywords: Existing chemicals; SAR; Toxicological database; NOEL; LOEL; Repeated dose toxicity; Rat; Mouse; Organ toxicity; Mechanisms/mode of action
Risk assessment of dietary acrylamide intake in Flemish adolescents
Keywords: IARC; International Agency for Research on Cancer; SNFA; Swedish National Food Administration; FAO/WHO; Food and Agriculture Organisation/World Health Organisation; LC-MS-MS; Liquid chromatography-mass spectrometry-mass spectrometry; US FDA; Unite
Antibiotics in the human food chain: Establishing no effect levels of tetracycline, neomycin, and erythromycin using a chemostat model of the human colonic microflora
Keywords: Tetracycline; Neomycin; Erythromycin; Microflora; Human; Intestinal; Chemostat; Residue; Trace; Low level; Acceptable daily intake; ADI; NOEL;
Review of the toxicology of carbonyl sulfide, a new grain fumigant
Keywords: COS; carbonyl sulfide; CS2; carbon disulfide; DMS; dimethyl sulfide; H2S; hydrogen sulfide; LC50; lethal concentration to 50% of test animals; NOEL; no (adverse) effect level; v/v; volume to volume; Fumigant; Exposure; Carbon disulfide; Neurotoxicity; Gen
Safety assessment of esters of p-hydroxybenzoic acid (parabens)
Keywords: DNCB; dinitrochlorobenzene; FEMA; flavor and extract manufacturers' association; GRAS; generally recognized as safe; MIC; minimum inhibitory concentration; NOAEL; no observed adverse effect level; NOEL; no observed effect level; OTC; over the counter; P
Criteria for the safety evaluation of flavoring substances
Keywords: ABS; chromosomal aberration; ADH; alcohol dehydrogenase; ALD; aldehyde dehydrogenase; AE; anethole epoxide; CYP450; Cytochrome P450; CHO; Chinese hamster ovary; CoA; coenzyme A; CoE; Council of Europe; CCK; cholecystokinin; DDA; detailed dietary analysis;