کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5861247 | 1562713 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Suitability of the in vitro Caco-2 assay to predict the oral absorption of aromatic amine hair dyes
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کلمات کلیدی
OECDno adverse effect levelTDANOELHPDNOAELP-gpAHTHCRTEERHcySCCsAPBHBSSAmCAMEHMAAEPCENAMPACPCaco-2AUC - AUCDMSO - DMSOP-glycoprotein - P-گلیکوپروتئینOral absorption - جذب دهانیIn vitro - درونکشتگاهیDimethyl sulfoxide - دیمتیل سولفواکسیدHair dyes - رنگ موOrganization for Economic Co-operation and Development - سازمان همکاری و توسعه اقتصادیCosmetics - لوازم آرایشیHank's balanced salt solution - محلول نمک متعادل هانکtransepithelial electrical resistance - مقاومت الکتریکی transepithelialarea under the curve - منطقه تحت منحنیPrediction - پیش بینیScientific Committee on Consumer Safety - کمیته علمی ایمنی مصرف کنندهHAp - گام
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Oral absorption is a key element for safety assessments of cosmetic ingredients, including hair dye molecules. Reliable in vitro methods are needed since the European Union has banned the use of animals for the testing of cosmetic ingredients. Caco-2 cells were used to measure the intestinal permeability characteristics (Papp) of 14 aromatic amine hair dye molecules with varying chemical structures, and the data were compared with historical in vivo oral absorption rat data. The majority of the hair dyes exhibited Papp values that indicated good in vivo absorption. The moderate to high oral absorption findings, i.e. â¥Â 60%, were confirmed in in vivo rat studies. Moreover, the compound with a very low Papp value (APB: 3-((9,10-dihydro-9,10-dioxo-4-(methylamino)-1-anthracenyl)amino)-N,N-dimethyl-N-propyl-1-propanaminium) was poorly absorbed in vivo as well (5% of the dose). This data set suggests that the Caco-2 cell model is a reliable in vitro tool for the determination of the intestinal absorption of aromatic amines with diverse chemical structures. When used in combination with other in vitro assays for metabolism and skin penetration, the Caco-2 model can contribute to the prediction and mechanistic interpretation of the absorption, metabolism and elimination properties of cosmetic ingredients without the use of animals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 32, April 2016, Pages 1-7
Journal: Toxicology in Vitro - Volume 32, April 2016, Pages 1-7
نویسندگان
Cindy Obringer, John Manwaring, Carsten Goebel, Nicola J. Hewitt, Helga Rothe,