کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849480 | 1561755 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Safety evaluation of rebaudioside A produced by fermentation
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کلمات کلیدی
Yarrowia lipolyticafermentativeGRASFDANOELRebaudioside AEFSAJECFAFCCSCFNOAELADI - NAMEEuropean Food Safety Authority - اداره ایمنی اروپاSafety evaluation - ارزیابی ایمنیSteviol glycosides - استیوول گلیکوزیدgenerally recognized as safe - به طور کلی به عنوان امن شناخته شده استAcceptable daily intake - دریافت روزانه قابل قبولFood and Drug Administration - سازمان غذا و داروJoint FAO/WHO Expert Committee on Food Additives - مجمع متخصص FAO / WHO در مورد مواد افزودنی مواد غذاییNo observed effect level - هیچ سطح اثر مشاهده شدهNo observed adverse effect level - هیچ عوارض جانبی مشاهده نشده
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The safety of rebaudioside A, produced fermentatively by Yarrowia lipolytica encoding the Stevia rebaudiana metabolic pathway (fermentative Reb A), is based on several elements: first, the safety of steviol glycosides has been extensively evaluated and an acceptable daily intake has been defined; second, the use of Y. lipolytica, an avirulent yeast naturally found in foods and used for multiple applications; and third the high purity of fermentative Reb A and its compliance with internationally defined specifications. A bacterial reverse mutation assay and an in vitro micronucleus test conducted with fermentative Reb A provide evidence for its absence of mutagenicity, clastogenicity and aneugenicity. The oral administration of fermentative Reb A to Sprague-Dawley rats for at least 91 days did not lead to any adverse effects at consumption levels up to 2057 mg/kg bw/day for males and 2023 mg/kg bw/day for females, which were concluded to be the No Observed Adverse Effect Levels. The results were consistent with outcomes of previous studies conducted with plant-derived rebaudioside A, suggesting similar safety profiles for fermentative and plant-derived rebaudioside A. The results of the toxicity studies reported here support the safety of rebaudioside A produced fermentatively from Y. lipolytica, as a general purpose sweetener.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 89, March 2016, Pages 73-84
Journal: Food and Chemical Toxicology - Volume 89, March 2016, Pages 73-84
نویسندگان
Mélina Rumelhard, Hiromi Hosako, Irene M.J. Eurlings, Walter M.A. Westerink, Lauren M. Staska, Jeanine A.G. van de Wiel, James La Marta,