کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849480 | 1561755 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Safety evaluation of rebaudioside A produced by fermentation
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کلمات کلیدی
Yarrowia lipolyticafermentativeGRASFDANOELRebaudioside AEFSAJECFAFCCSCFNOAELADI - NAMEEuropean Food Safety Authority - اداره ایمنی اروپاSafety evaluation - ارزیابی ایمنیSteviol glycosides - استیوول گلیکوزیدgenerally recognized as safe - به طور کلی به عنوان امن شناخته شده استAcceptable daily intake - دریافت روزانه قابل قبولFood and Drug Administration - سازمان غذا و داروJoint FAO/WHO Expert Committee on Food Additives - مجمع متخصص FAO / WHO در مورد مواد افزودنی مواد غذاییNo observed effect level - هیچ سطح اثر مشاهده شدهNo observed adverse effect level - هیچ عوارض جانبی مشاهده نشده
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Safety evaluation of rebaudioside A produced by fermentation Safety evaluation of rebaudioside A produced by fermentation](/preview/png/5849480.png)
چکیده انگلیسی
The safety of rebaudioside A, produced fermentatively by Yarrowia lipolytica encoding the Stevia rebaudiana metabolic pathway (fermentative Reb A), is based on several elements: first, the safety of steviol glycosides has been extensively evaluated and an acceptable daily intake has been defined; second, the use of Y. lipolytica, an avirulent yeast naturally found in foods and used for multiple applications; and third the high purity of fermentative Reb A and its compliance with internationally defined specifications. A bacterial reverse mutation assay and an in vitro micronucleus test conducted with fermentative Reb A provide evidence for its absence of mutagenicity, clastogenicity and aneugenicity. The oral administration of fermentative Reb A to Sprague-Dawley rats for at least 91 days did not lead to any adverse effects at consumption levels up to 2057 mg/kg bw/day for males and 2023 mg/kg bw/day for females, which were concluded to be the No Observed Adverse Effect Levels. The results were consistent with outcomes of previous studies conducted with plant-derived rebaudioside A, suggesting similar safety profiles for fermentative and plant-derived rebaudioside A. The results of the toxicity studies reported here support the safety of rebaudioside A produced fermentatively from Y. lipolytica, as a general purpose sweetener.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 89, March 2016, Pages 73-84
Journal: Food and Chemical Toxicology - Volume 89, March 2016, Pages 73-84
نویسندگان
Mélina Rumelhard, Hiromi Hosako, Irene M.J. Eurlings, Walter M.A. Westerink, Lauren M. Staska, Jeanine A.G. van de Wiel, James La Marta,