کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8550943 | 1562105 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Study on the developmental toxicity of β-ionone in the rat
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کلمات کلیدی
NCRResearch Institute for Fragrance MaterialsRIFMFDANOELJECFANOAELTeratogenicityγ-GTOECDLD50CyPGRASADI - NAMEβ-Ionone - β-یونونγ-glutamyltransferase - γ-گلوتامیل ترانسفرازUS Food and Drug Administration - اداره غذا و داروی ایالات متحدهFood additives - افزودنی های مواد غذاییgenerally recognized as safe - به طور کلی به عنوان امن شناخته شده استBIO - بیوAcceptable daily intake - دریافت روزانه قابل قبولlethal dose 50% - دوز مرگبار 50٪gestation day - روز بارداریOrganisation for Economic Co-operation and Development - سازمان همکاری اقتصادی و توسعهReproductive toxicity - سمیت تولید مثلEmbryotoxicity - سمیت عصبیCytochrome P450 - سیتوکروم پی۴۵۰MIO - منWeight - وزن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
β-ionone (BIO) is used in fragrances, toiletries and non-cosmetic products, and as a flavor food additive. Notwithstanding the widespread human exposure, there are limited data on the reproductive toxicity of BIO. This study evaluated the developmental toxicity of BIO (0, 125, 250, 500 and 1000â¯mg/kg body weight/day) given orally to rats on days 6-15 of gestation (GD6-15). C-section was on GD21 and implantations, living and dead fetuses and resorptions were recorded. Fetuses were weighed, and examined for external abnormalities and skeleton and visceral anomalies. The embryotoxicity of a single oral dose of BIO (1000â¯mg/kg body wt) given on GD11 was evaluated as well. At the highest dose, BIO reduced weight gain and produced chromodacryorrhea and other signs of toxicity. BIO did not increase the frequency of malformations nor did it retard fetal growth. Nonetheless, BIO decreased the pregnancy rate in the group of females exposed on GD6-15, and increased the resorption rate in those treated on GD11 only. In conclusion, except for a higher embryolethality at a maternally toxic dose, BIO caused no embryotoxic effect over the dose range tested and the study NOAEL for maternal and developmental toxicity was 500â¯mg of BIO/ kg of body weight/day.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 97, August 2018, Pages 110-119
Journal: Regulatory Toxicology and Pharmacology - Volume 97, August 2018, Pages 110-119
نویسندگان
Flávia C.M. Pinto, Rosangela R. De-Carvalho, Ana Cecilia A.X. De-Oliveira, Isabella F. Delgado, Francisco J.R. Paumgartten,