کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2116927 | 1085044 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Existence of no-observed effect levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline on hepatic preneoplastic lesion development in BN rats
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کلمات کلیدی
DenHepatocarcinogenesisNOELGST-PMeIQx2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline - 2-amino-3،8-dimethylimidazo [4،5-f] quinoxaline2-acetylaminofluorene - 2-استامینامین فلوئورنStrain differences - اختلاف فشارCancer risk assessment - ارزیابی خطر سرطانglutathione S-transferase placental form - فرم جفتی گلوتاتیون S-transferase
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Existence of no-observed effect levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline on hepatic preneoplastic lesion development in BN rats Existence of no-observed effect levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline on hepatic preneoplastic lesion development in BN rats](/preview/png/2116927.png)
چکیده انگلیسی
There is increasing evidence that dose-response curve of genotoxic carcinogen is nonlinear and a practical threshold dose exists. However, little is known about differences in the dose-response relationship of genotoxic carcinogen among different strain rats. Herein, we showed that low doses of genotoxic carcinogen 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx) had no effects on induction of liver glutathione S-transferase placental form (GST-P)-positive foci in both BN and F344 rats, and therefore demonstrated the existence of no-observed effect level for hepatocarcinogenicity of this genotoxic carcinogen irrespective of strains. These findings further support our notion that a practical threshold dose for MeIQx hepatocarcinogenicity exists in rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 231, Issue 2, 18 January 2006, Pages 304-308
Journal: Cancer Letters - Volume 231, Issue 2, 18 January 2006, Pages 304-308
نویسندگان
Min Wei, Taka-aki Hori, Toshio Ichihara, Hideki Wanibuchi, Keiichirou Morimura, Jin Seok Kang, Rawiwan Puatanachokchai, Shoji Fukushima,