کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5560398 | 1403319 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
FEMA expert panel review of p-mentha-1,8-dien-7-al genotoxicity testing results
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کلمات کلیدی
ethylmethanesulfonateNOAELGLPJECFAMTDNOELFEMAOECDEMSNASi.p.EFSAFEMA GRASthe Flavor and Extract Manufacturers AssociationppmSCENTPMSDIS-9Chromosomal aberration - انحراف کروموزومیNational Toxicology Program - برنامه سم شناسی ملیSister chromatid exchange - تبادل کروماتید خواهرGood Laboratory Practice - تمرین خوب آزمایشگاهیMaximum tolerated dose - حداکثر دوز قابل تحملintraperitoneal - داخل صفاقیOrganization for Economic Cooperation and Development - سازمان همکاری های اقتصادی و توسعهno-observed-effect level - سطح بدون مشاهدۀ اثرGenotoxicity - سمیت ژنتیکیparts per million - قطعات در میلیونJoint FAO/WHO Expert Committee on Food Additives - مجمع متخصص FAO / WHO در مورد مواد افزودنی مواد غذاییFlavoring ingredients - مواد تشکیل دهنده طعم دهندهMicronucleus - میکروسکوپMale - نرno-observed-adverse-effect level - هیچ عارضه ای مشاهده نشدbody weight - وزن بدنPerilla - پرایلاPerillaldehyde - پریلالدئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
p-Mentha-1,8-dien-7-al is a naturally occurring cyclic alpha,beta-unsaturated aldehyde that is used as a flavoring substance throughout the world. Due to the chemical structure and the potential DNA reactivity of the alpha,beta-unsaturated carbonyl moiety, a battery of genotoxicity assays was requested by the European Food Safety Authority. Previous genotoxicity studies on the substance gave mixed results, but both positive and negative results were hampered by not always being performed to any standard guideline. The new test battery data indicated some evidence of mutagenicity in vitro, but an in vivo comet/micronucleus combination assay performed in rats was concluded by the study directors to not result in any biologically relevant positive responses. However, EFSA concluded that the in vivo assay gave evidence that p-mentha-1,8-dien-7-al was of potential genotoxic concern. The Expert Panel of the Flavor and Extract Manufacturers Association (FEMA) has reviewed the newly available data and considered its interpretation relative to standard guidelines such as that established by the Organization for Economic Cooperation and Development, and has concluded that the results in the comet/micronucleus combination assay are consistent with the interpretation by the study directors; namely, that p-mentha-1,8-dien-7-al does not appear to have any in vivo genotoxic potential.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 98, Part B, December 2016, Pages 201-209
Journal: Food and Chemical Toxicology - Volume 98, Part B, December 2016, Pages 201-209
نویسندگان
Samuel M. Cohen, Shoji Fukushima, Nigel J. Gooderham, F. Peter Guengerich, Stephen S. Hecht, Ivonne M.C.M. Rietjens, Robert L. Smith, Maria Bastaki, Christie L. Harman, Margaret M. McGowen, Sean V. Taylor,