کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849418 | 1561753 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A two-year dietary carcinogenicity study of (2R,4R)-monatin salt in mice
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کلمات کلیدی
AAALACno-observed-effect-levelFDANOELGLPNOAELGGTOECDALTIACUCADMEHPLC/MS/MS - HPLC / MS / MSAlanine aminotransferase - آلانین آمینوترانسفرازUS Food and Drug Administration - اداره غذا و داروی ایالات متحدهAssociation for Assessment and Accreditation of Laboratory Animal Care - انجمن ارزیابی و اعتباربخشی مراقبت از حیوانات آزمایشگاهیstandard deviation - انحراف معیارSafety - ایمنیGood Laboratory Practice - تمرین خوب آزمایشگاهیabsorption, distribution, metabolism and excretion - جذب، توزیع، متابولیسم و دفعInstitutional Animal Care and Use Committee - سازمان مراقبت و مراقبت از حیواناتOrganisation for Economic Co-operation and Development - سازمان همکاری اقتصادی و توسعهCarcinogenicity - سرطان زاییHigh performance liquid chromatography tandem mass spectrometry - طیف سنجی جرمی کروماتوگرافی با عملکرد بالاDietary - غذاییICH - منMice - موشno-observed-adverse-effect level - هیچ عارضه ای مشاهده نشدInternational Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use - کنفرانس بین المللی هماهنگی الزامات فنی ثبت دارویی برای استفاده انسانیGamma-glutamyl transferase - گاما گلوتامیل ترانسفراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A two-year dietary carcinogenicity study of (2R,4R)-monatin salt in mice A two-year dietary carcinogenicity study of (2R,4R)-monatin salt in mice](/preview/png/5849418.png)
چکیده انگلیسی
Groups of Crl:CD-1 (ICR) mice (60/group/sex) were fed 0 (2 control groups), 5000, 20,000, or 40,000 ppm of enzymatically sourced (2R,4R)-monatin salt (“R,R-monatin”) in the diet for up to two years. There were no adverse effects on survival, incidence of palpable masses and tumors, feed consumption, hematology or serum chemistry parameters, organ weights, or ophthalmic, macroscopic, and microscopic examinations. The only notable effect was statistically significantly lower mean body weights and body weight gains in all treated groups, which generally occurred throughout the study and were most likely a result of caloric dilution of the test diets and not considered adverse. There were no test article-related changes in the incidence or occurrence of neoplastic diseases in mice on this study. The no-observed-effect-level (NOEL) for carcinogenicity of R,R-monatin fed to mice for 24 months was 40,000 ppm, the highest dietary concentration tested, which was equivalent to approximately 6502 and 7996 mg/kg bw/day in males and females, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 91, May 2016, Pages 191-201
Journal: Food and Chemical Toxicology - Volume 91, May 2016, Pages 191-201
نویسندگان
Witty A. Brathwaite, Christine M. Crincoli, Alex K. Eapen, Marisa O. Rihner, Andrey I. Nikiforov, Catherine A. Picut,