Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism and excretion; AUC; area under the blood/plasma concentration time curve; BMDL; lower 95% confidence limit of the benchmark dose; Cmax; maximum blood/plasma concentration; NOAEL; no-observed-adverse-effect-level;
مقالات ISI جذب، توزیع، متابولیسم و دفع (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism and excretion; AFND; allele frequency net database; ALT; alanine aminotransferase; AOP; adverse outcome pathway; AOP-KB; AOP knowledge base; AST; aspartate aminotransferase; BSEP; bile salt export protein; CAR; c
Keywords: جذب، توزیع، متابولیسم و دفع; Arg-Gly-Asp; Arginylglycylaspartic acid; FDA; Food and Drug Administration; DNA; Deoxyribonucleic acid; NCI; National Cancer Institute; SCLC; Small cell lung cancers; NSCLC; Non-small cell lung cancers; 5-FU; 5-Fluorouracil; OTCs; Organic cationic transpo
Pharmacokinetics, tissue distribution and excretion of luteolin and its major metabolites in rats: Metabolites predominate in blood, tissues and are mainly excreted via bile
Keywords: جذب، توزیع، متابولیسم و دفع; Luteolin; Metabolite; Pharmacokinetics; Bioavailability; Distribution; Excretion; ADME; absorption, distribution, metabolism and excretion; AUC; area under the curve; BCRP; breast cancer resistance protein; CE; collision energy; Cmax; peak concentration;
Keywords: جذب، توزیع، متابولیسم و دفع; AD; Alzheimer disease; ADME; absorption, distribution, metabolism and excretion; AO; adverse outcome; AOP; adverse outcome pathway; AOP-KB; adverse outcome pathway knowledge base; BDNF; brain derived neurotrophic factor; B/H; Bradford-Hill; CI; complex I
Keywords: جذب، توزیع، متابولیسم و دفع; Risk assessment; Less than lifetime exposure; Fluctuating exposure; Intermittent exposure; ADME; absorption, distribution, metabolism and excretion; AUC; area under the blood/plasma concentration time curve; BMDL; lower 95% confidence limit of the benchma
Keywords: جذب، توزیع، متابولیسم و دفع; 5α-R; 5α-reductase type 2; ADME; absorption, distribution, metabolism and excretion; AG; andrographolide; AGD; anogenital distance; AOP; adverse outcome pathway; AR; androgen receptor; BPAD; biological pathway altering dose; CHH; congenital hypogonadotr
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism and excretion; A(O)EL; Acceptable (Operator) Exposure Level; BMDL; lower 95% confidence limit of the benchmark dose; HLV; Human Limit Value; MoS; Margin of Safety; NOAEL; No-Observed-Adverse-Effect-Level; OEL; Oc
Keywords: جذب، توزیع، متابولیسم و دفع; DILI; drug induced liver injury; FDA; Food and Drug Administration; NIH; National Institute of Health; LTKB; Liver Toxicity Knowledge Base; QSAR; quantitative structure activity relationship; ADME; absorption, distribution, metabolism and excretion; ALT;
Keywords: جذب، توزیع، متابولیسم و دفع; AAN; aristolochic acid nephropathy; ADME; absorption, distribution, metabolism and excretion; CYT P450; cytochrome P450; DPP-IV; dipeptidyl peptidase IV; GLP1; glucagon like peptide 1; GLUT4; glucose transporter 4; GSH; glutathione; GST; glutathione-S-tra
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism and excretion; 3D; three-dimensional; 3T3; “3-day transfer” mouse fibroblast cell line; AGGR; aggregating brain cell cultures; DIV; day in vitro; EU CLP; European regulation on classification, labelling and p
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism and excretion; AUC; area under the blood/plasma concentration time curve; BMDL; benchmark dose lower limit; NOAEL; no-observed-adverse-effect level; TK; toxicokinetics; C,t-curve; blood/plasma concentration-time
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism and excretion; ADMET; absorption, distribution, metabolism, excretion and toxicity; FDA; USA Food and Drug Administration; GWAS; genome-wide association study; mTOR; mammalian target of rapamycin; NME; new molecu
Cell cultures in drug discovery and development: The need of reliable in vitro-in vivo extrapolation for pharmacodynamics and pharmacokinetics assessment
Keywords: جذب، توزیع، متابولیسم و دفع; 3Rs; Reduction, Replacement, Refinement; PBPK; physiologically based pharmacokinetic; 2D; two-dimensional; 3D; three-dimensional; HTS; high-throughput screening; IVIVE; in vitro-in vivo extrapolation; ADME; absorption, distribution, metabolism and excreti
High-performance liquid chromatography coupled to inductively coupled plasma - Mass spectrometry (HPLC-ICP-MS) for quantitative metabolite profiling of non-metal drugs
Keywords: جذب، توزیع، متابولیسم و دفع; Quantitative drug metabolite profiling; Inductively coupled plasma - (tandem) mass spectrometry coupled to high-performance liquid chromatography; Spectral interference; Chemical resolution; Chemical derivatization for ICP-MS detection; ICP-MS(/MS); ind
In silico and in vitro analysis of coumarin derivative induced anticancer effects by undergoing intrinsic pathway mediated apoptosis in human stomach cancer
Keywords: جذب، توزیع، متابولیسم و دفع; SBC; Apoptosis; Docking; ADME; Stomach cancer cell line (AGS); Anti-proliferative; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; ADME; absorption, distribution, metabolism and excretion; FBS; fetal bovine serum; RPMI; rosewell park m
Role of efflux transporters in the absorption, distribution and elimination in rodents of a novel PDE4 inhibitor, CHF6001
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism and excretion; AUC0-t(last); area under the concentration-time curve up to the last measurable concentration; AUCinf; area under the concentration-time curve up to infinity; AUCÏ; area under the concentration-ti
Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism and excretion; Clint; intrinsic clearance; Clp; plasma clearance; Clu; unbound clearance; DCM; dichloromethane; DHEP; dog hepatocytes; DLM; dog liver microsomes; DMAc; dimethylacetamide; DMF; dimethylformamide; D
Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception
Keywords: جذب، توزیع، متابولیسم و دفع; Pharmacokinetics; Inflammation; Nociception; Safety pharmacology; IS01957; Para-coumaric acid derivative; p-CA; Para coumaric acid; ADME; Absorption, distribution, metabolism and excretion; CH; Chlorpromazine hydrochloride; PS; Pentobarbital sodium; PBS;
Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A
Keywords: جذب، توزیع، متابولیسم و دفع; Botulism; Botulinum toxin; Botulinum neurotoxin; Mercaptoacetamide; Metalloprotease inhibitor; SNAP-25; SNARE protein; X-ray crystallography; ADME; absorption, distribution, metabolism and excretion; BAT®; heptavalent botulism antitoxin; BHSAI; Biotechno
In Vitro-In Vivo Extrapolation of Metabolism- and Transporter-Mediated Drug-Drug Interactions-Overview of Basic Prediction Methods
Keywords: جذب، توزیع، متابولیسم و دفع; drug interaction; cytochrome P450s; membrane transport/transporters; regulatory; guidance/guideline; ADME; absorption, distribution, metabolism and excretion; BCRP; breast cancer resistance protein; CYP; cytochrome P-450; d; induction calibration factor;
Interaction between the zebrafish (Danio rerio) organic cation transporter 1 (Oct1) and endo- and xenobiotics
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism and excretion; ASP+; 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide; DAPI; 4â²,6-diamidino-2-phenylindole; DBT; dibutyltin chloride; DMEM; Dulbecco's modified eagle's medium; HEK239; human embryonic kid
Integrating RNA sequencing into neuro-oncology practice
Keywords: جذب، توزیع، متابولیسم و دفع; CNS; central nervous system; RNA-seq; RNA sequencing; qRT-PCR; quantitative reverse transcription polymerase chain reaction; NGS; next-generation sequencing; GBM; glioblastoma; SNPs; single nucleotide polymorphisms; exRNAs; extracellular RNAs; lncRNAs; lo
In vitro and in silico characterisation of Tacrolimus released under biorelevant conditions
Keywords: جذب، توزیع، متابولیسم و دفع; Tacrolimus (PubChem CID: 5282315); ACAT; advanced compartmental and transit; ADME; absorption, distribution, metabolism and excretion; ANOVA; analysis of variance; API; active pharmaceutical ingredient; BCS; biopharmaceutics classification system; CL; cle
A two-year dietary carcinogenicity study of (2R,4R)-monatin salt in mice
Keywords: جذب، توزیع، متابولیسم و دفع; Carcinogenicity; R,R-Monatin; Mice; Safety; Dietary; AAALAC; Association for Assessment and Accreditation of Laboratory Animal Care; ADME; absorption, distribution, metabolism and excretion; ALT; alanine aminotransferase; FDA; US Food and Drug Administrat
A combined dietary chronic toxicity and two-year carcinogenicity study of (2R,4R)-monatin salt in Sprague-Dawley rats
Keywords: جذب، توزیع، متابولیسم و دفع; Carcinogenicity; Chronic; Rat; Safety; Dietary; (2R,4R)-Monatin; AAALAC; Association for Assessment and Accreditation of Laboratory Animal Care; ADME; absorption, distribution, metabolism and excretion; FDA; US Food and Drug Administration; GLP; Good Labo
ReviewIn silico pharmacology: Drug membrane partitioning and crossing
Keywords: جذب، توزیع، متابولیسم و دفع; ABC; ATP-binding cassette; ADME; absorption, distribution, metabolism and excretion; AMP; antimicrobial peptide; CG; coarse-grained; COX; cyclooxygenase; CYP; cytochrome P450; DLiPC; dilinoeyl-phosphatidylcholine; DOPC; 1,2-dioleoyl-sn-glycero-3-phosphoch
A systems pharmacology approach to decipher the mechanism of danggui-shaoyao-san decoction for the treatment of neurodegenerative diseases
Keywords: جذب، توزیع، متابولیسم و دفع; DSS; danggui-shaoyao-san; NDs; neurodegenerative diseases; TCM; traditional Chinese medicine; AD; Alzheimer's disease; PD; Parkinson's disease; HD; Huntington's disease; ALS; amyotrophic lateral sclerosis; AIA; aspirin-intolerant asthma; PRA; Paeoniae Rad
Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors
Keywords: جذب، توزیع، متابولیسم و دفع; Coumarins; Factor XIIa; Factor XII; FXII; Antithrombotic agents; Benzopyrans; ADME; absorption, distribution, metabolism and excretion; FXIIa; activated coagulation factor XII; FXa; activated coagulation factor X; THR; thrombin; FVIIa; activated factor VI
In vivo toxicity studies of fusarium mycotoxins in the last decade: A review
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism and excretion; AFs; aflatoxins; ALT; alanine aminotransferase; HFB1; aminopentol; AS; aluminosilicate; AST; aspartate aminotransferase; AUC; area under curve; BEA; beauvericin; bw; body weight; CAT; catalase; CYP
Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilities
Keywords: جذب، توزیع، متابولیسم و دفع; ACAT; acyl CoA:cholesterol acyltransferase; ADME; absorption, distribution, metabolism and excretion; APCI; atomospheric pressure chemical ionization; CM; chylomicron; dba; dibenzylideneacetone; CYP; cytochrome P450; DDI; drug-drug interaction; DGAT; ac
Quantification of biliary excretion and sinusoidal excretion of 5(6)-carboxy-2â²,7â²-dichlorofluorescein (CDF) in cultured hepatocytes isolated from Sprague Dawley, Wistar and Mrp2-deficient Wistar (TRâ) rats
Keywords: جذب، توزیع، متابولیسم و دفع; BC; bile canaliculae; CDF; 5(6)-carboxy-2â²,7â²-dichlorofluorescein; CDF-DA; CDF-diacetate; abcc1-6; ATP-binding cassette, sub-family C (CFTR/MRP) member 1-6; Mrp1-6; multidrug resistance associated protein 1-6; BEI; biliary excretion index; Oatp; organ
Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase
Keywords: جذب، توزیع، متابولیسم و دفع; BLM; Bloom helicase; SAR; structure activity relationship; HTS; high throughput screen; ADME; absorption, distribution, metabolism and excretion; MLM; mouse liver microsomes; NADPH; nicotinamide adenine dinucleotide phosphate; PBS; phosphate buffered sali
Determination of n-octanol/water partition coefficients of weak ionizable solutes by RP-HPLC with neutral model compounds
Keywords: جذب، توزیع، متابولیسم و دفع; Kow; n-Octanol/water partition coefficient; RP-HPLC; Reversed-phase high performance liquid chromatography; kw; P-HPLC retention factor of the solute corresponding to the neat aqueous fraction of mobile phase; Kowâ³; Apparent n-octanol/water partition co
Metastatic disease: A drug discovery perspective
Keywords: جذب، توزیع، متابولیسم و دفع; GEMM; genetically engineered mouse models; ADME; absorption, distribution, metabolism and excretion; PK; pharmacodynamics; ECM; extracellular matrix; EMT; epithelial-mesenchymal transition; MET; mesenchymal-epithelial transition; NSCLC; non-small cell
Compatibility art of traditional Chinese medicine: From the perspective of herb pairs
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism and excretion; APL; acute promyelocytic leukemia; CHM; Chinese herbal medicine; CYP2E1; Cytochrome P450 2E1; dl-THP; dl-tetrahydropalmatine; HIF1α; hypoxia-inducible factor-1alpha; HUVECs; human umbilical vascul
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease
Keywords: جذب، توزیع، متابولیسم و دفع; Acetylcholinesterase inhibitors; Butyrylcholinesterase inhibitors; Quinolizidine derivatives; Bi- and tricyclic systems derivatives; Single-entity multi-target agents; Aβ; β-amyloid; ACh; acetylcholine; AChE; acetylcholinesterase; AD; Alzheimer's dise
Analysis of Chinese herbal medicines with holistic approaches and integrated evaluation models
Keywords: جذب، توزیع، متابولیسم و دفع; Absorption, distribution, metabolism and excretion; ADME; Capillary electrophoresis combined with mass spectrometry; CE-MS; Chinese herbal medicine; Chromatographic fingerprinting; Gas chromatography combined with mass spectrometry; GC-MS; Holistic approa
Research perspectives for pre-screening alternatives to animal experimentation
Keywords: جذب، توزیع، متابولیسم و دفع; MEIC; Multicenter Evaluation of In vitro Cytotoxicity program; REACH; Registration, Evaluation, Authorisation and Restriction of Chemicals system; HTS; high throughput screening; MTS; medium throughput screening; ED; endocrine disruptor; ADME; absorption,