Risk assessment of endocrine active chemicals: Identifying chemicals of regulatory concern

► Endocrine disruption criteria combining regulatory toxicity and mechanistic studies. ► These combined adverse effects with mode of action of toxicity. ► Refinement to discriminate endocrine disrupting chemicals of low and higher concern. ► For human health specificity and potency to induce endocrine toxicity is considered. ► For ecotoxicology further population relevance and negligible exposure is proposed.