کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5856826 | 1131984 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of the dose decrement in regulatory rat pesticide toxicity feeding studies
ترجمه فارسی عنوان
تعیین ضریب دوز در مطالعات تغذیه سموم سمنتوم موش صحرایی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
In typical rodent pesticide feeding studies of 4 up to 104Â weeks, animals are offered the pesticide at constant concentrations in the feed. Throughout the entire study duration of up to 104Â weeks, the daily feed consumption per animal remains nearly constant. This results in decreasing doses per kg bodyweight from the first day of treatment onwards as the bodyweight increases. Recently, we have identified this dose decrement as the major cause for lower No Observed Effect Levels (NOAEL, expressed as mg/kg bodyweight) in longer-term studies compared to shorter-term studies, rather than the exposure duration itself. In the current evaluation we investigated the nature of the dose decrement in more detail by using male and female bodyweight and feed consumption data from 118 feeding studies of three rat strains to calculate dose development over time. In male rats, after a steep initial dose decrement, the mean dose at week 7 of treatment is on average half of the initial dose and after 29Â weeks one third of the initial dose. In females, 50% of the initial dose is reached at week 18 and in 25% of the studies one third of the initial dose is reached at approximately 75Â weeks of treatment. Although bodyweights and feed intakes per animal were different between strains, doses and dose development curves over time are similar. The fact that ingested doses in rats continually decrease, especially in the first 13Â weeks, should be taken into account in dietary risk assessments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 67, Issue 2, November 2013, Pages 215-220
Journal: Regulatory Toxicology and Pharmacology - Volume 67, Issue 2, November 2013, Pages 215-220
نویسندگان
Jürg A. Zarn, Barbara E. Engeli, Josef R. Schlatter,