کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5855751 | 1562122 | 2016 | 9 صفحه PDF | دانلود رایگان |
- The effects of the solvent N-ethyl-2-pyrrolidone were evaluated in a 4-week oral toxicity study in SD rats.
- Treatment-related effects on the liver and kidney were observed.
- Male rats appeared to be more sensitive than females.
The solvent N-ethyl-2-pyrrolidone (NEP) was evaluated in a 4-week repeated dose study in rats. NEP diluted in distilled water was orally administered by gavage to male and female Sprague-Dawley rats at doses of 0 (vehicle control), 5, 50, and 250Â mg/kg/day for 28 consecutive days. Transient decreases in the body weight and in the body weight gain of the males was observed during the first days of treatment at the 50 and 250Â mg/kg/day doses. There was a marked increase in urine volume at the beginning of treatment in males and female rats at doses of 50 and 250Â mg/kg/day. No biologically significant differences were observed in hematological and clinical chemistry values in males and females at necropsy. Histological examination revealed an increase in hyaline droplets in the renal tubules of the kidneys and hepatocellular centrilobular hypertrophy in the liver of males at 250Â mg/kg/day. Cytochrome P450 concentration in liver microsomes was slightly increased at 250Â mg/kg/day in males. The results of this study demonstrate that NEP has mild to no effects at doses up to 250Â mg/kg/day when administered orally to rats for 28 days with males being more susceptible than females.
Journal: Regulatory Toxicology and Pharmacology - Volume 81, November 2016, Pages 275-283