کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8554174 | 1562700 | 2017 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro safety and efficacy evaluations of a complex botanical mixture of Eugenia dysenterica DC. (Myrtaceae): Prospects for developing a new dermocosmetic product
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کلمات کلیدی
photoirritation factorOMCEDEPIFBCOPDNCBMUSSTCBPIIC50IVISMPEITSSPF1-chloro-2,4-dinitrobenzene - 1-کلرو-2،4-دینیتروبنزن3,4-dihydroxy-l-phenylalanine - 3،4-دی هیدروکسیل-فنیل آلانینUN GHS - GHSl-DOPA - L-DOPANRU - NOcytokinesis-block micronucleus assay - آزمون میکرونوکلئوس بلوک سیتوکینزیRisk evaluation - ارزیابی ریسکIntegrated testing strategies - استراتژی تست یکپارچهOctyl methoxycinnamate - اکتیل متوقف سیناماتneutral red uptake - جذب قرمز خالصBovine Corneal Opacity and Permeability - خلوص و نفوذپذیری قرنیه گاوAlternative methods - روش های جایگزینUnited Nations Globally Harmonized System of Classification and Labelling of Chemicals - سازمان ملل متحد سیستم جهانی طبقه بندی و برچسب زدن مواد شیمیاییstimulation index - شاخص تحریکCytokinesis-block proliferation index - شاخص تکثیر بلوک سیتوکینزیسAnti-aging - ضد پیریSun protection factor - عامل حفاظت از خورشیدCosmetic - لوازم آرایشی و بهداشتیPropidium iodide - پروتئین یدیدoptical density - چگالی نوری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
In the context of developing a new natural product-based cosmetic, the in vitro efficacy and safety evaluations of a complex botanical mixture based on Eugenia dysenterica leaf hydroalcoholic extract (EDE) (2.5-1000 μg/mL) were carried out. Chromatographic analysis demonstrated the presence of the tannin (ellagic acid) and flavonoids (quercetin and gallic acid) which characterize the EDE as a polyphenol-rich mixture. Using HFF-1 fibroblasts, it was shown that EDE promoted cell regeneration after UVA exposure. It also led to the inhibition of the collagenase, elastase and tyrosinase enzymes, which are involved in skin-related disorders. In terms of toxicological evaluation, the EDE was classified as non-phototoxic through the 3T3 Neutral Red Uptake Phototoxicity Test (OECD N° 432, 2004) and non-eye irritant by Bovine Corneal Opacity and Permeability (OECD N° 437, 2013) assay, in conjunction with corneal histomorphometric analysis. Furthermore, the EDE has no skin sensitization potential as demonstrated by a two-out-of-three prediction model [protein-binding/haptenization (OECD N° 442C, 2015), keratinocyte and dendritic cell activations]. In addition, it was shown that the EDE seems to be non-genotoxic through the cytokinesis-block micronucleus assay (OECD N° 487, 2014) using HepG2 cells. When considered together, these findings support the use of EDE botanical mixture in cosmetic/pharmaceutical products.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 45, Part 3, December 2017, Pages 397-408
Journal: Toxicology in Vitro - Volume 45, Part 3, December 2017, Pages 397-408
نویسندگان
Larissa Cleres Moreira, Renato Ivan de Ávila, Danillo Fabrini Maciel Costa Veloso, Tatiana Nascimento Pedrosa, Emerson Silva Lima, Renê Oliveira do Couto, Eliana Martins Lima, Aline Carvalho Batista, José Realino de Paula, Marize Campos Valadares,