Keywords: A; alanine; AOP; adverse outcome pathway; C; cysteine; Cys; cysteine; DNCB; 2,4-Dinotrochlorobenzene; DPRA; direct peptide reactivity assay; EGDMA; Ethylene glycol dimethacrylate; F; phenylalanine; FN; false negative; FP; false positive; GHS; Global harmo
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Keywords: acupuncture; allergic contact dermatitis; DNCB; mice;
Keywords: AOO; acetone/olive oil; BrdU; 5-bromo-2'-deoxyuridine; CHS; contact hypersensitivity; DMF; N,N-dimethylformamide; DNCB; 1-chloro-2,4-dinitrobenzene; HCA; hexyl cinnamic aldehyde; LLNA; local lymph node assay; mAb; monoclonal antibody; MS; methyl salicyl
Keywords: 5hmC; 5-Hydroxymethylcytosine; 5mC; 5-Methylcytosine; AOO; Acetone:olive oil; DMR; Differentially methylated region; DNCB; 2,4-Dinitrochlorobenzene; hMmeDIP; Hydroxymethylated DNA immunoprecipation; IFN; Interferon; IL; Interleukin; IP; Immunoprecipitated
Keywords: Trx; thioredoxin; TrxR; thioredoxin reductase; TrxR1; thioredoxin reductase 1; Sec or U; selenocysteine; Cys or C; cysteine; Trp or W; tryptophan; Ser or S; serine; Asn or N; asparagine; Ala or A; alanine; Gly or G; glycine; juglone; 5-hydroxy-1,4-naphtho
Keywords: Contact hypersensitivity; eosinophil-deficient; sensory nerve; degranulation; DNCB; Dinitrochlorobenzene; DNFB; Dinitrofluorobenzene; EAI; Eosinophil activity index; EPX-mAb; Eosinophil peroxidase-specific monoclonal antibody; PGP 9.5; Pan-neuronal antibo
Keywords: CA; cinnamaldehyde; C-OH; cinnamic alcohol; DiSFeB; Dipartimento di Scienze Farmacologiche e Biomolecolari; DNCB; dinitrochlorobenzene; DMF; dimethylformamide; DMSO; dimethylsulfoxide; DSA05 (μg/cm2); induction dose per skin area (DSA) that produces a po
Ameliorative effects of Juniperus rigida fruit on oxazolone- and 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice
Keywords: JFE; Juniperus rigida fruit EtOH extract; AD; atopic dermatitis; DNCB; 2,4-dinitrochlorobenzene; IL-4; interleukin-4; IgE; immunoglobulin E; Th2; T-helper cell type-2; TEWL; transepidermal water loss; PMA; phorbol 12-myristate 13-acetate; Juniperus rigida
Pyrus ussuriensis Maxim. leaves extract ameliorates DNCB-induced atopic dermatitis-like symptoms in NC/Nga mice
Keywords: Pyrus ussuriensis Maxim; Atopic dermatitis; NC/Nga mice; 2, 4-dinitrochlorobenzene; Interleukins; IgE; PUL; Pyrus ussuriensis Maxim. Leaves; AD; Atopic dermatitis; NO; Nitric oxide; IL-6; Interleukin 6; IL-1β; Interleukin 1β; TNF-α; tumor necrosis fact
Total sesquiterpene lactones isolated from Inula helenium L. attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice
Keywords: Inula helenium L.; Total sesquiterpene lactones; Anti-inflammatory; Atopic dermatitis; SLs; Sesquiterpene lactones; TSL-IHL; total sesquiterpene lactones; AL; alantolactone; IAL; isoalantolactone; RA; rheumatoid arthritis; AD; atopic dermatitis; DNCB; 2,4
Immune-modulation via IgD B-cell receptor suppresses allergic skin inflammation in experimental contact hypersensitivity models despite of a Th2-favoured humoral response
Keywords: ACD; allergic contact dermatitis; AD; atopic dermatitis; BAFF; B-cell activating factor; BCR; B-cell receptor; Breg; regulatory B cells; CD40L; CD40 ligand; CHS; contact hypersensitivity; DNCB; 2,4 dinitrochlorobenzene; FcRs; Fc receptors; FcγRβII; Fc g
Jageum-Jung improves 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice and suppresses pro-inflammatory chemokine production by inhibiting TNF-α/IFN-γ-induced STAT-1 and NFκB signaling in HaCaT cells
Keywords: AD; atopic dermatitis; DAD; diode array UV/VIS detector; DMSO; dimethyl sulfoxide; DNCB; 2,4-dinitrochlorobenzene; DNP-HAS; dinitrophenyl-human serum albumin; ELISA; Enzyme-linked immunosorbent assay; ERK; extracellular signal-regulated kinases; FBS; fe
GPCR Kinase (GRK)-2 Is a Key Negative Regulator of Itch: l-Glutamine Attenuates Itch via a Rapid Induction of GRK2 in an ERK-Dependent Way
Keywords: Ad-GRK2; adenovirus expressing GPCR kinase-2; CD; contact dermatitis; CQ; chloroquine; DNCB; dinitrochlorobenzene; Gln; l-glutamine; GRK; GPCR kinase; MKP-1; MAPK phosphatase-1; siRNA; small interfering RNA;
Inhibitory effect of Patrinia scabiosifolia Link on the development of atopic dermatitis-like lesions in human keratinocytes and NC/Nga mice
Keywords: AD; Atopic dermatitis; DNCB; 2,4-dinitrochlorobenzene; MCP-1; Monocyte chemotactic protein-1; PBS; Phosphate-buffered saline; PS; Patrinia scabiosifolia; RBC; red blood cell; SDS-PAGE; sodium dodecyl sulfate-polyacrylamide gel electrophoresis; Anti-inflam
Dendritic cells' death induced by contact sensitizers is controlled by Nrf2 and depends on glutathione levels
Keywords: ACD; allergic contact dermatitis; BMDC; bone marrow dendritic cells; CinA; cinnamaldehyde; CHS; contact hypersensitivity; CS; contact sensitizer; DNCB; 2,4-dinitrochlorobenzene; GSH; glutathione; GPX1; Glutathione peroxidase 1; GSR; Glutathione-S-reductas
Comparison and validation of an in vitro skin sensitization strategy using a data set of 33 chemical references
Keywords: Ac; Acylating agents; ACD; Allergic Contact Dermatitis; AOP; Adverse Outcome Pathway; ARE; Antioxidant Response Element; DC; dendritic cell; DMSO; dimethyl sulfoxide; DNCB; dinitrochlorobenzene; DPRA; Direct Peptide Reactivity Assay; ECVAM; European Centr
In vitro safety and efficacy evaluations of a complex botanical mixture of Eugenia dysenterica DC. (Myrtaceae): Prospects for developing a new dermocosmetic product
Keywords: AAAPVN; N-succinyl-ala-ala-ala-p-nitroanilide; BCOP; Bovine Corneal Opacity and Permeability; CBPI; cytokinesis-block proliferation index; CV80; non-cytotoxic concentration of test substance that maintain cell viability â¥Â 80%; DNCB; 1-chloro-2,4-dinitr
Topical Application of Dieckol Ameliorates Atopic Dermatitis in NC/Nga Mice by Suppressing Thymic Stromal Lymphopoietin Production
Keywords: AD; atopic dermatitis; BMDC; bone marrow-derived dendritic cell; DC; dendritic cell; DNCB; 2,4-dinitrochlorobenzene; HDM; house dust mite; IKKβ; inhibitor of NF-κB kinase subunit beta; OX40L; OX40 ligand; TSLP; thymic stromal lymphopoietin;
Lactobacillus pentosus KF340 alleviates house dust mite-induced murine atopic dermatitis via the secretion of IL-10-producing splenic B10 cells
Keywords: Lactobacillus pentosus KF340; Atopic dermatitis; B10 cells; BAFF; Dendritic cells; AADCs; alternative activated DCs; AD; atopic dermatitis; APRIL; a proliferation-inducing ligand; BAFF; B cell-activating factor; B10; IL-10-producing Breg; CFU; colony form
Sesquiterpene lactones of Moquiniastrum polymorphum subsp. floccosum have antineoplastic effects in Walker-256 tumor-bearing rats
Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; Cat; catalase; DNCB; 2,4-dinitrochlorobenzene; EDTA; ethylenediaminetetraacetic acid; EtOAc; ethyl acetate; F1B; dichloromethane fra
Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2
Keywords: AMC; 7-amino-4-methylcoumarin; CDDO-Me; methyl-2-cyano-3,12-dioxooleana-1, 9(11)dien-28-oate; DNCB; 2,4-dinitrochlorobenzene; Gclm; glutamate-cysteine ligase regulatory subunit; HIF-1α; hypoxia-inducible factor 1α; IAA; iodoacetamide; Keap1; Kelch-lik
Sceptridium ternatum attenuates allergic contact dermatitis-like skin lesions by inhibiting T helper 2-type immune responses and inflammatory responses in a mouse model
Keywords: ACD; allergic contact dermatitis; DNCB; 2,4-dinitrochlorobenzene; IgE; immunoglobulin E; IL-4; interleukin-4; IFN-γ; interferon-γ; LPS; lipopolysaccharide; NO; nitric oxide; ST; Sceptridium ternatum ethanol extract; TNF-α; tumor necrosis factor-α; All
Topical application of Kochia scoparia inhibits the development of contact dermatitis in mice
Keywords: Kochia scoparia; Contact dermatitis; DNCB; Cytokine; Inflammation
Performance of the N/TERT epidermal model for skin sensitizer identification via Nrf2-Keap1-ARE pathway activation
Keywords: N/TERT; Reconstructed human epidermis; Skin sensitization; Keap1; Nrf2; DNCB;
Introduction of a methoxymethyl side chain into p-phenylenediamine attenuates its sensitizing potency and reduces the risk of allergy induction
Keywords: PPD; p-phenylenediamine; PTD; p-toluylenediamine; ME-PPD; 2-methoxymethyl-p-phenylenediamine; LLNA; local lymph node assay; QRA; quantitative risk assessment; SCCS; Scientific Committee on Consumer Safety; HE-PPD; hydroxyethyl-PPD; WoE; weight-of-evidence
Proteomic allergen-peptide/protein interaction assay for the identification of human skin sensitizers
Keywords: ACD; allergic contact dermatitis; APIA; allergen-peptide/protein interaction assay; CA; cinnamic aldehyde; DNCB; 2,4-dinitrochlorobenzene; MS; mass spectrometry; SA; salicylic acid; Skin sensitization; Small reactive chemicals; Adduct formation; Chemica
Alleviation of abnormal synaptic neurotransmitter release by cell-permeable form of the truncated SNAP-25 upon transcutaneous delivery
Keywords: SNAP-25; synaptosome-associated protein of 25Â kDa; VAMP; vesicle-associated membrane protein; SNARE; soluble N-ethylmaleimide-sensitive factor attachment protein receptor; BoNT; Botulinum neurotoxin; DBS; deep brain stimulation; BBB; blood-brain barrie
Development of an in vitro skin sensitization test based on ROS production in THP-1 cells
Keywords: BH; 1-bromohaxane; BKC; benzalkonium chloride; CB; chlorobenzene; CM-H2DCFDA; 5-(and 6-)-chloromethyl-2â², 7â²-dichlorodihydrofluorescein diacetate, acetyl ester; DCs; dendritic cells; DCV5; concentration showing 5% decrease of cell viability relative
A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis
Keywords: AP1; activator protein-1; ASK1; apoptosis signal-regulating kinase 1; CBB; Coomassie brilliant blue; DMEM; Dulbecco's modified Eagle's medium; DNCB; dinitrochlorobenzene; DTNB; dithiobisnitrobenzoic acid; GRs; glutathione reductases; HIF-1α; hypoxia-indu
Topical application of Taglisodog-eum inhibits the development of experimental atopic dermatitis
Keywords: TSE; Taglisodog-eum; LPS; Lipopolysaccharide; PMA; Phorbol 12-myristate 13-acetate; AD; Atopic dermatitis; Th1 & Th2; T helper 1 and T helper 2; IL-4; Interleukin 4; IL-5; Interleukin 5; IL-10; Interleukin 10; IL-13; Interleukin 13; IL-17; Interleukin 17;
The contribution of thioredoxin-2 reductase and glutathione peroxidase to H2O2 detoxification of rat brain mitochondria
Keywords: ROS; reactive oxygen species; Trx2; thioredoxin-2; GSH; glutathione; SOD; superoxide dismutase; DNCB; 1-chloro-2,4-dinitrobenzene; L-GP; L-α-glycerophosphate; Rat brain mitochondria; Hydrogen peroxide metabolism; Thioredoxin-2 reductase; Glutathione pero
Systemic immunomodulatory effects of topical dinitrochlorobenzene (DNCB) in rats. Activity of peripheral blood polymorphonuclear cells
Keywords: Rats; DNCB; Skin sensitization; Peripheral blood ploymorphonuclears
Putting the parts together: Combining in vitro methods to test for skin sensitizing potentials
Keywords: ARE; antioxidant response element; AUC; area under the curve; C.C; control cells; CV75; concentration reducing viability to 75%; DC; dendritic cells; DMSO; dimethyl sulfoxide; DNCB; 1-chloro-2,4-dinitrobenzene; DPRA; Direct Peptide Reactivity Assay; ECHA;
Inhibitory effects of Chelidonium majus extract on atopic dermatitis-like skin lesions in NC/Nga mice
Keywords: AD; atopic dermatitis; CM; Chelidonium majus; IL-4; interleukin-4; IgE; immunoglobulin E; TNF-α; tumor necrosis factor-α; DNCB; 1-chloro-2,4-dinitrobenzene; NOR; normal group; CON; control group; CMP 1; Chelidonium majus Methanol Extract 100 mg/kg, p.o
Suppression of dust mite extract and 2,4-dinitrochlorobenzene-induced atopic dermatitis by the water extract of Lindera obtusiloba
Keywords: AD; atopic dermatitis; LOWE; Lindera obtusiloba water extract; DFE; Dermatophagoides farinae extract; DNCB; 2,4-dinitrochlorobenzenel; IL; interleukin; Atopic dermatitis; Lindera obtusiloba; IgE; Skin inflammation; Mast cell;
Topical application of porcine placenta extract inhibits the progression of experimental contact hypersensitivity
Keywords: PE; placenta extract; LPS; lipopolysachharide; TNF-α; tumor necrosis factor alpha; IL-1β; interleukin 1 beta; IFN-γ; interferon gamma; IL-4; interleukin 4; IL-6; interleukin 6; IL-2; interleukin 2; IL-17; interleukin 17; CHS; contact hypersensitivity;
The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: Results of a ring-study in five laboratories
Keywords: LLNA; local lymph node assay; Nrf2; nuclear factor-erythroid 2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; ARE; antioxidant response element; SOP; standard operating procedure; WLR; within laboratory reproducibility; BLR; between laborat
ReviewChemical reactivity measurements: Potential for characterization of respiratory chemical allergens
Keywords: ACD; allergic contact dermatitis; AHCP; ammonium hexachloroplatinate; APC; antigen presenting cells; Da; Dalton; DAD; diode array detector; DC; dendritic cell; DNCB; 2,4-dinitrochlorobenzene; DNFB; 2,4-dinitrofluorobenzene; DTT; d,l-dithiothreitol; EC50;
Cellular and Molecular NeuroscienceResearch PaperHistamine H1, H3 and H4 receptors are involved in pruritus
Keywords: pruritus; histamine; H1 receptor; H3 receptor; H4 receptor; dorsal root ganglia neurons; CPS; capsaicin; DiI; 1,1â²-dioctadecyl-3,3,3â²,3â²-tetramethylindocarbocyanine perchlorate; DMSO; dimethyl sulphoxide; DNCB; 2,4-dinitrochlorobenzene; DRG; dorsal
Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB
Keywords: DILI; drug-induced liver injury; CRMs; chemically reactive metabolites; GSH; glutathione; Nrf2; nuclear factor-erythroid 2 (NF-E2)-related factor; NF-κB; NF-kappa B; ARE; anti-oxidant response element; NAPQI; N-acetyl-p-benzoquinineimine; DNCB; dinitroch
Validation of a mouse model of chemical-induced asthma using trimellitic anhydride, a respiratory sensitizer, and dinitrochlorobenzene, a dermal sensitizer
Keywords: Trimellitic anhydride; 1-chloro-2; 4-dinitrobenzene; occupational asthma; murine model; T-lymphocytes subtypes; IL-4; IFN-γ; macrophage inflammatory protein 2; TNF-α; AOO; Acetone olive oil; AUC; Area under the curve; BAL; Bronchoalveolar lavage; ConA;
Therapy for genital human papillomavirus-related disease
Keywords: AIN; anal intraepithelial neoplasia; CI; confidence interval; CIN; cervical intraepithelial neoplasia; COPV; canine oral papillomavirus; DNCB; dinitrochlorobenzene; 5-FU; 5-fluorouracil; HPV; human papillomavirus; HR; high-oncogenic risk; HSIL; high-grade
Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4+ T-cells
Keywords: AOO; 4:1 acetone:olive oil; DNCB; 2,4-dinitrochlorobenzene; ELISA; enzyme-linked immunosorbant assay; LNC; lymph node cell; NOB; nitrosobenzene; PBS; phosphate buffered saline; SI; stimulation index; SMX; sulfamethoxazole; SMX-NHOH; sulfamethoxazole hydro
Capacity of CD34+ progenitor-derived dendritic cells to distinguish between sensitizers and irritants
Keywords: Dendritic cells; CD34+ progenitor cells; Allergens; Phenotype markers; Cytokines; BC; benzalkonium chloride; CD34-DC; dendritic cells derived from CD34+ cord blood cells; CIN; alpha-hexylcinnamaldehyde; DC; dendritic cells; DNBS; dinitrobenzenesulfonic ac
Safety assessment of esters of p-hydroxybenzoic acid (parabens)
Keywords: DNCB; dinitrochlorobenzene; FEMA; flavor and extract manufacturers' association; GRAS; generally recognized as safe; MIC; minimum inhibitory concentration; NOAEL; no observed adverse effect level; NOEL; no observed effect level; OTC; over the counter; P