کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6283248 | 1615155 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Alleviation of abnormal synaptic neurotransmitter release by cell-permeable form of the truncated SNAP-25 upon transcutaneous delivery
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کلمات کلیدی
DBSBoNTPTDVAMPDNCBSNARECMAPSNAP-25SNARE complex - SNARE پیچیدهdeep brain stimulation - تحریک عمقی مغزDrug delivery - تحویل(رهایش) داروProtein transduction domain - دامنه انتقال پروتئینDinitrochlorobenzene - دینیتروکلروبنزنBlood–brain barrier - سد خونی مغزیBBB - سد خونی مغزیAnti-wrinkle - ضد چروکBotulinum neurotoxin - نوروتوکسین بوتولینومcompound muscle action potential - پتانسیل عمل عضله مرکبVesicle-associated membrane protein - پروتئین غشاء مرتبط با Vesiclesynaptosome-associated protein of 25 kDa - پروتئین مرتبط با سیناپتوزوم 25 کیلو دالتونsoluble N-ethylmaleimide-sensitive factor attachment protein receptor - گیرنده پروتئین دلبستگی حساس به پروتئین محلول N-ethylmaleimide
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Alleviation of abnormal synaptic neurotransmitter release by cell-permeable form of the truncated SNAP-25 upon transcutaneous delivery Alleviation of abnormal synaptic neurotransmitter release by cell-permeable form of the truncated SNAP-25 upon transcutaneous delivery](/preview/png/6283248.png)
چکیده انگلیسی
Abnormal releases of neurotransmitters result in movement disorders such as dystonia, chorea, tics, blepharospasm and wrinkle formation, and intra-muscular injection of Botulinum neurotoxin is widely used for the treatment of these complications. But it is potentially poisonous and must be intra-muscularly injected with precision by a well-trained physician. For novel therapeutic development with high safety profile and easy skin penetration for these complications, we generated Trans-X, a cell permeable form of the truncated SNAP-25 that is one of the SNARE complex for vesicle exocytosis of neuron. Upon topical administration, Trans-X efficiently penetrated through skin, reached the dermis layer and remained stable. Trans-X, which did not show any ocular or skin allergic sensitivity, can block the pre-synaptic neurotransmitter transport via acting as a competitive inhibitor of SNARE complex formation, and effectively induced muscle paralysis comparable to BOTOX® evaluated by measuring compound muscle action potential. Topical treatment of the facial skin with Trans-X in clinical study can prevent the wrinkle formation and improve the skin roughness. Therefore, our study suggests that Trans-X may be a convenient and effective medical and cosmetic treatment for local management of movement disorder without systemic toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 543, 24 May 2013, Pages 52-57
Journal: Neuroscience Letters - Volume 543, 24 May 2013, Pages 52-57
نویسندگان
Tae-Yoon Park, Min-Jung Shin, Sung-Dong Park, Sang-Kyou Lee,