کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5857947 | 1562154 | 2016 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A systematic evaluation of the potential effects of trichloroethylene exposure on cardiac development
ترجمه فارسی عنوان
ارزیابی سیستماتیک اثرات بالقوه تری کلروتیلن بر روی رشد قلب
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کلمات کلیدی
DCAMouse Genome InformaticsBMDSWOEBMDLCHDMGIBMRBMDTCAAOPEPAPODNTPTCEU.S. Environmental Protection Agency - آژانس حفاظت از محیط زیست ایالات متحدهdichloroacetic acid - اسید dichloroacetictrichloroacetic acid - اسید ترشکلراکتیکMalformations - اصلاحاتNational Toxicology Program - برنامه سم شناسی ملیTrichloroethylene - تریکلرواتیلن benchmark dose - دوز معادلIntegrated Risk Information System - سیستم اطلاعات ریسک مجتمعIris - عنبیهconfidence interval - فاصله اطمینانCardiac - قلبadverse outcome pathway - مسیر ناخوشایندbenchmark response - معیار پاسخCongenital heart defects - نقص مادرزادی قلبPoint of departure - نقطه عزیمت
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
The 2011 EPA trichloroethylene (TCE) IRIS assessment, used developmental cardiac defects from a controversial drinking water study in rats (Johnson et al. [51]), along with several other studies/endpoints to derive reference values. An updated literature search of TCE-related developmental cardiac defects was conducted. Study quality, strengths, and limitations were assessed. A putative adverse outcome pathway (AOP) construct was developed to explore key events for the most commonly observed cardiac dysmorphologies, particularly those involved with epithelial-mesenchymal transition (EMT) of endothelial origin (EndMT); several candidate pathways were identified. A hypothesis-driven weight-of-evidence analysis of epidemiological, toxicological, in vitro, in ovo, and mechanistic/AOP data concluded that TCE has the potential to cause cardiac defects in humans when exposure occurs at sufficient doses during a sensitive window of fetal development. The study by Johnson et al. [51] was reaffirmed as suitable for hazard characterization and reference value derivation, though acknowledging study limitations and uncertainties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 65, October 2016, Pages 321-358
Journal: Reproductive Toxicology - Volume 65, October 2016, Pages 321-358
نویسندگان
Susan L. Makris, Cheryl Siegel Scott, John Fox, Thomas B. Knudsen, Andrew K. Hotchkiss, Xabier Arzuaga, Susan Y. Euling, Christina M. Powers, Jennifer Jinot, Karen A. Hogan, Barbara D. Abbott, E. Sidney III, Michael G. Narotsky,