Rapamycin prevents bronchiolitis obliterans through increasing infiltration of regulatory BÂ cells in a murine tracheal transplantation model

Mammalian target of rapamycin inhibition decreases the development of bronchiolitis obliterans via inhibition of proinflammatory cytokines and increasing regulatory B lymphocytes cell infiltration, which subsequently produces anti-inflammatory cytokines and upregulates regulatory T lymphocyte cells.