Keywords: Cancer metabolism; Combinatory therapy; Glutaminase isoenzymes; Glutamine; Glutaminase inhibitors; Metabolic reprogramming; DON; 6-diazo-5-oxy-L-norleucine; EATC; Ehrlich ascites tumour cells; ERK; extracellular signal-regulated kinases; GA; glutaminase;
مقالات ISI (ترجمه نشده)
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Keywords: Antiplatelet; Preclinical studies; Structure-activity relationship (SAR) studies; Pharmacokinetic parameters; Safety profile; AA; arachidonic acid; ADP; adenosine diphosphate; ATP; adenosine triphosphate; CNS; central nervous system; COX-1; cyclooxygenase
Keywords: BSA; bovine serum albumin; C1P; ceramide 1-phosphate; PKB; protein kinase B; ERK; extracellularly regulated kinases; FBS; fetal bovine serum; PTX; pertussis toxin; PI3K; phosphatidylinositol 3-kinase; DMH4; 6-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-phenylpy
Keywords: AD; Alzheimer's disease; BBB; blood brain barrier; RAGE; Receptor for Advanced Glycation End products; AGE; advanced glycation end products; IL1β; interleukin 1 beta; Aβ; amyloid beta; TNF â;  tumor necrosis factor alpha; TGFβ; transforming growth
Keywords: AIPC; Androgen-independent prostate cancer; AKAP1; cAMP signaling; AML; acute myeloid leukemia; BAK; Bcl-2 homologous antagonist killer; BAX; Bcl-2-associated X protein; BCL-2; B-cell lymphoma 2; BMRP; BCL-2 interacting mitochondrial ribosomal protein; C7
Keywords: Diabetic embryopathy; Phospholipid; PTEN; PKB; AKT; mTOR; Reactive oxygen species; Mitochondrion;
Keywords: Breast cancer; Necrosis; Apoptosis; Cytotoxicity; Cancer therapeutics; HMA; 5-(N,N-hexamethylene) amiloride; DCFH-DA; carboxy-2â²,7â²-dichloro-dihydro-fluorescein diacetate; ROS; reactive oxygen species; PI3K; phosphatidylinositol-3 kinase; PKB; protein
Keywords: Oligodendrocytes; Brain injury; Adult; Neonatal; Remyelination; Regeneration; Repair; Development; Pharmaceutical; CNS; Central nervous system; WM; white matter; OPC; oligodendrocyte progenitor cell; OL; oligodendrocyte; SVZ; subventricular zone; EAE; exp
Keywords: AD; Alzheimer's disease; T2DM; type II diabetes mellitus; Aβ; amyloid beta; NFT; neurofibrillary tangles; IR; insulin resistance; InsR; insulin receptors; IRS; InsR substrate; IGF; insulin growth factor; ICV; intracerebroventricular; STZ; streptozotocin;
Keywords: 8-OHdG; 8-oxo-2â²-deoxyguanosine; AMPK; AMP-activated protein kinase; ANT; adenine nucleotide translocator; Bad; Bcl2-associated agonist of cell death; BKA; bongkrekic acid; CAT; catalase; CsA; cyclosporine A; Cu/Zn-SOD; Cu/Zn-superoxide dismutase; DR4;
Keywords: OS; oxidative stress; CNS; central nervous system; ROS; reactive oxygen species; SOD; superoxide dismutase; CAT; catalase; Cu; copper; Zn; zinc; Mn; manganese; Fe; iron; Ni; nickel; DA; dopamine; PHOX; NADPH oxidase; Nrf2; nuclear factor erythroid 2-relat
Keywords: ACTH; adrenocorticotropic hormone; DN; double negative; Dll; delta-like ligand; DP; double positive; HPA-axis; hypothalamus-pituitary-adrenal axis; HSD; hydroxysteroid-dehydrogenase; IL; interleukin; SP; single positive; IFN; interferon; TEC; thymic epith
Keywords: Adrenomedullin; Fetal HPMEC; Hyperoxic injury; Inflammation; Akt; AM; adrenomedullin; Adm; adrenomedullin gene; ARDS; acute respiratory distress syndrome; BPD; bronchopulmonary dysplasia; CM-H2DCF-DA; 5-(and-6)-chloromethyl-2â², 7â²-dichlorodihydrofluor
Keywords: pKa; pKb; Supercritical; Water; Corrosion
Keywords: ABCA1; ATP-binding cassette transporter A1; ABCG1; ATP-binding cassette transporter G1; SR-BI; scavenger receptor BI; SR-A; scavenger receptor class A; ACAT1; acyl coenzyme A:cholesterol acyltransferase-1; nCEH; neutral cholesteryl ester hydrolase; ox-LDL
Keywords: NO; nitric oxide; NOS; nitric oxide synthase; iNOS; inducible nitric oxide synthase; LPS; lipopolysaccharide; AD; Alzheimer's disease; CNS; central nervous system; ESR; electron spin resonance; PKB; protein kinase B; RT-PCR; reverse transcriptase polyme
Keywords: Abl; Abelson leukemia proto-oncogene; ADAP; adhesion and degranulation promoting adapter protein (Fyb, SLAP-130); Asc; apoptosis-associated speck-like protein containing a CARD; BCR; B-cell receptor; C3G; Crk SH3 domain-binding guanine nucleotide exchange
Keywords: AP-1; adaptor protein 1; ASL; airway surface liquid; CCO; cytochrome c oxidase; CF; cystic fibrosis; COX-2; cyclooxygenase 2; Csk; c-src kinase; DMEM; Dulbeccos' minimal essential medium; DMT1; divalent metal ion transporter 1; DUOX; dual oxidase; EGFR;
Keywords: Inositol; Insulin resistance; Diabetes; Polycystic ovary syndrome; Metabolic syndrome; Diabetic neuropathy; AC; adenylyl cyclase; ACC; acetyl-coenzyme A carboxylase; AGEs; advanced glycation end products; AMP; adenosine monophosphate; cAMP; cyclic AMP; AM
Keywords: AMPK; AMP activated protein kinase; ECM; extracellular matrix; EGFR; epidermal growth factor receptor; EMT; epithelial-mesenchymal transition; ERK; extracellular signal-regulated kinase; FLIP; FLICE inhibitory protein; FAK; focal adhesion kinase; GSK-3;
The mechanisms and clinical significance of PDCD4 in colorectal cancer
Keywords: Abbreviations; Full name in English; 3â²-UTR; 3â²-untranslated region; AA; asiatic acid; AOM; azoxymethane; AP-1; activating protein 1; AR; aldose reductase; ATF; activating transcription factor; Bcl-2; B-cell lymphoma 2; CAC; colitis-associated CRC; CD
Different concentrations of docosahexanoic acid supplement during lactation result in different outcomes in preterm Sprague-Dawley rats
Keywords: DHA; Docosahexanoic acid; LCPUFA; long chain polyunsaturated fatty acid; PKB; protein kinase B; mTORC1; mammalian target of rapamycin complex 1; Sug; sufficient DHA Group; Eng; enriched DHA Group; Exg; excess DHA Group; DeG; deficient DHA Group; PND; post
Rho kinase, a potential target in the treatment of metabolic syndrome
Keywords: WHO; World Health Organization; NCEP-ATP III; the National Cholesterol Education Program Adult Treatment Panel III; IDF; the International Diabetes Federation; JIS; the Joint Interim Societies; NCEP; National Cholesterol Education Program; MetS; metabolic
Combined Fluoroscopy and Ultrasound-Guided Transjugular Kidney Biopsy in Cirrhotic Patients
Keywords: PKB; percutaneous kidney biopsy; TJKB; transjugular kidney biopsy;
6,7,4â²-Trihydroxyisoflavone suppressed the estrogen receptor negative breast cancer growth via regulating glycogen synthase kinase-3β/β-catenin signaling
Keywords: Breast cancer; β-catenin; Cell cycle; Glycogen synthase kinase-3β; Trihydroxyisoflaovone; CDK; cyclin dependent kinase; CDKI; cyclin dependent kinase inhibitor; ER; estrogen receptor; ERK; extracellular signal-regulated kinase; GSK; glycogen synthase ki
Role of SOCE architects STIM and Orai proteins in Cell Death
Keywords: SOCE; store operated Ca2+ entry; STIM1/2; stromal interaction molecule 1/2; NFAT; nuclear factor of activated T-cells; IP3; inositol trisphosphate; ARC; arachidonic acid-regulated channels; LRC; leukotriene C4-regulated channels; PKB; protein kinase B; PK
Prep1 deficiency improves metabolic response in white adipose tissue
Keywords: C/EBP; CCAAT/enhancer binding protein; CD; cluster of differentiation; FABP4; fatty acid binding protein 4; GLUT4; glucose transporter 4; HK1; hexokinase 1; IFNgamma; interferon gamma; IR; insulin receptor; MCP1; monocyte chemotactic protein 1; MIP-1; mac
Re-evaluating the role of FOXOs in cancer
Keywords: RTK; receptor tyrosine kinase; GF; growth factor; PI3K; Phosphatidylinositol-4,5-bisphosphate 3-kinase; PKB; protein kinase B; AKT; RAC-alpha serine/threonine-protein kinase; FOXO; forkhead box O; GFR; growth factor receptor; PDPK1; Phosphoinositide-depen
Acute extracellular matrix, inflammatory and MAPK response to lengthening contractions in elderly human skeletal muscle
Keywords: LC; lengthening contractions; ECM; extracellular matrix; TGF-β; transforming growth factor-beta; TGF-βRII; transforming growth factor-beta receptor II; SMAD; Mothers against decapentaplegic homolog; MAPK; mitogen activated protein kinase; JNK; c-Jun N-t
The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes
Keywords: Akt2-KO; Akt2 gene deletion; CHO; Chinese hamster ovary; DM; diabetes mellitus; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; GLUT4; glucose transporter type-4; GS; glycogen synthase; GSK-3; glycogen synt
HBP1 phosphorylation by AKT regulates its transcriptional activity and glioblastoma cell proliferation
Keywords: DNMT1; DNA-methyltransferase 1; FOXO; Forkhead box O transcription factors; GST; glutathione S-transferase; HBP1; HMG-box protein 1; HEK; human embryonic kidney; HMG; high mobility group; HPLC; high performance liquid chromatography; KD; kinase dead; MS;
Inhibition of protein tyrosine phosphatase 1B by flavonoids: A structure - activity relationship study
Keywords: Diabetes mellitus; PTP1B inhibition; Flavonoids; Enzymatic inhibition type; DM; Diabetes mellitus; GLUT4; glucose transporter 4; IR; insulin receptor; IRS; insulin receptor substrates; Km; Michaelis constant; PKB; protein kinase B; pNPP; p-nitrophenyl pho
Pharmacological inhibition of 2-arachidonoilglycerol hydrolysis enhances memory consolidation in rats through CB2 receptor activation and mTOR signaling modulation
Keywords: JZL184; Rat; Monoacylglycerol lipase (MAGL); Inhibitory avoidance; Fear memory; Behavior; JZL184 [4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester]; MAGL inhibitor; SR141716 [5-(4-chlorophenyl)-1-(2,4-dichlorophen
Mitochondria-associated membranes (MAMs): An emerging platform connecting energy and immune sensing to metabolic flexibility
Keywords: Organelle communication; Mitochondria-associated membranes; Nutrients; Microbiome; Innate immunity; Insulin sensitivity; Metabolic diseases; Ca2+; calcium; CLRs; C-type lectin receptors; CypD; cyclophilin D; DAMPs; Danger-Associated Molecular patterns; ER
The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance
Keywords: ABCB1; ATP-binding cassette sub-family B member 1; AML; acute myeloid leukaemia; AMPK; adenosine monophosphate-activated protein kinase; ATM; Ataxia-telangiectasia mutated; AURKA; aurora kinase A; BER; base excision repair; Bim; B-cell lymphoma 2 interact
Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway
Keywords: Agmatine; Akt; HT22; Ketamine; Neuroprotection; p70S6 kinase; PSD95; 4E-BPs; 4E binding proteins; ANOVA; analysis of variance; DMEM; Dulbecco's Modified Eagle Medium; ECT; electroconvulsive therapy; CUS; chronic unpredictable stress; FST; forced swim test
Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin
Keywords: Nrf2 activation; Pyridone; Enone; Aldol condensation; Nrf2; nuclear factor erythroid 2 related factor 2; CNS; central nervous system; Keap1; Kelch-like ECH associated protein 1; NF-κB; nuclear factor kappa-light-chain enhancer of activated B cells; Maf;
Selective serotonin reuptake inhibitors affect structure, function and metabolism of skeletal muscle: A systematic review
Keywords: Serotonin (Pubchem CID: 5202); Fluoxetine (Pubchem CID: 3386); Citalopram (Pubchem CID: 2771); Escitalopram (Pubchem CID:146570); Fluvoxamine (Pubchem CID: 5324346); Dexamethasone (Pubchem CID: 5743); Insulin (Pubchem CID:70678557); SSRIs; selective serot
AGC kinases, mechanisms of regulation âand innovative drug development
Keywords: AGC kinase; group of kinases related to PKA PKG and PKC; PKA; protein kinase A; PKC; protein kinase C; PKG; protein kinase G; PRK; protein kinase C related kinase (also termed PKN protein kinase N); PDK1; 3-phosphoinositide-dependent protein kinase 1; PKB
Neuroprotective effect of zolpidem against glutamate-induced toxicity is mediated via the PI3K/Akt pathway and inhibited by PK11195
Keywords: ANC; adenine nucleotide carrier; H2O2; hydrogen peroxide; LDH; lactate dehydrogenase; mPTP; mitochondrial permeability transition pore; PI3K; phosphatidylinositol-3-kinase; PK11195; 1-(-2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents
Keywords: MAPK; RAF inhibitors; Anti-cancer agents; Abl; Abelson murine leukemia viral oncogene; ATP; Adenine triphosphate; Bcl-2; B-cell lymphoma; CNS; Central nervous system; COX-2; Cyclo-oxygenase enzyme-2; CR; Conserved region; CRD; Cysteine-rich domain; DFG; A
ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway
Keywords: Akt; oncogene in the transforming retrovirus, AKT8; AP-1; activator protein 1; ARAF; v-raf murine sarcoma 3611 viral oncogene homologue; ASK1; apoptosis signal-regulating kinase 1; BCL2; B-cell lymphoma 2; BCL-XL; B-cell lymphoma extra large; BRAF; v-raf
Hyaluronan carried by tumor-derived microvesicles induces IL-10 production in classical (CD14++CD16â) monocytes via PI3K/Akt/mTOR-dependent signalling pathway
Keywords: DCs; dendritic cells; HA; hyaluronan; IRF; interferon regulatory factor; MOI; multiplicity of infection; PKB; protein kinase B; RNI; reactive nitrogen intermediates; ROI; reactive oxygen species; mTOR; mammalian target of rapamycin; TIM; tumor-infiltratin
Research paperSodC modulates ras and PKB signaling in Dictyostelium
Keywords: Ras; PKB; Superoxide;
Identification of natural allosteric inhibitor for Akt1 protein through computational approaches and in vitro evaluation
Keywords: PKB; protein kinase B; CPH; common pharmacophore hypothesis; RMSE; root mean-square error; PLS; partial least-squares; QSAR; quantitative structure-activity relationship; TCM; traditional Chinese medicine; HTVS; high-throughput virtual screening; SP; stan
Fructose induced neurogenic hypertension mediated by overactivation of p38 MAPK to impair insulin signaling transduction caused central insulin resistance
Keywords: BP; blood pressure; CNS; central nervous system; eNOS; endothelial nitric oxide synthase; ERK; extracellular signal-regulated kinases; HR; heart rate; IRS; insulin receptor substrate; MAPK; mitogen-activated protein kinase; MEK; MAP kinase-ERK kinase; NO;
Cytochrome P450-derived eicosanoids and heart function
Keywords: AA; arachidonic acid; ACS; acute coronary syndrome; ALA; alpha-linolenic acid; AMI; acute myocardial infarction; AMPK; 5Ⲡadenosine monophosphate-activated protein kinase; Ang II; angiotensin II; ANP; atrial natriuretic peptide; BaP; benzo(α)pyrene; BK
MAP kinase signaling and Elk1 transcriptional activity in hibernating thirteen-lined ground squirrels
Keywords: ATF2; activating transcription factor 2; bZIP; basic leucine zipper; Ca2Â +; Â calcium; CREB; cAMP-responsive element binding protein; DPI-ELISA; DNA-protein interaction enzyme-linked immunosorbent assay; EA; early arousal; EC; euthermic control; Elk1; ET
Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes
Keywords: 4E-BP1; eukaryotic initiation factor 4E-binding protein 1; AMPK; AMP-activated protein kinase; BSA; bovine serum albumin; ConA; concanavalin A; eEF2; eukaryotic elongation factor 2; eIF; eukaryotic initiation factor; ERK; extracellular-signal-regulated
The RAS/PI3K Pathway is Involved in the Impairment of Long-term Potentiation Induced by Acute Aluminum Treatment in Rats
Keywords: Aluminum; Long-term potentiation; RAS; PKB; AMPA receptor;