Over-expression of AQP7 contributes to improve insulin resistance in adipocytes
Keywords: Aquaglyceroporin 7 (AQP7); PKB; 3T3-L1 adipocytes; Insulin resistance;
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The role of amino acid transporters in GSH synthesis in the blood-brain barrier and central nervous system
Keywords: AA; amino acid; AARE; amino acids response elements; ApN; aminopeptidase N; ARE; antioxidant response element; BBB; blood-brain barrier; BEC; brain endothelial cell; CNS; central nervous system; CSF; cerebrospinal fluid; EC; endothelial cell; ERK; extra
The phosphoinositide 3-kinase inhibitor LY294002, decreases aminoacyl-tRNA synthetases, chaperones and glycolytic enzymes in human HT-29 colorectal cancer cells
Keywords: CRC; colorectal cancer; DMSO; dimethyl sulfoxide; ECL; enhanced chemiluminescence; ESI; electrospray ionization; FCS; fetal calf serum; HRP; horse-radish peroxidase; IC50; half maximal inhibitory concentration; IEF; isoelectric focusing; IPG; immobilized
mTOR inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes
Keywords: BCA; bicinchoninic acid protein; ECL; enhanced chemiluminescence; IR; insulin receptor; mTOR; mammalian target of rapamycin; mTORC1; mammalian target of rapamycin complex 1; mTORC2; mammalian target of rapamycin complex 2; NODAT; new onset diabetes after
Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice
Keywords: 5-HT; 5-hydroxytryptamine; 5-HIAA; 5-hydroxyindolacetic acid; AD; Alzheimer's disease; DA; Dopamine; DOPAC; 3,4-dihydroxyphenylacetic acid; EPI; Epinephrine; HPLC; high performance liquid chromatography; HVA; homovanillic acid; LTD; long-term depression
Calpain regulates N-terminal interaction of GSK-3β with 14-3-3ζ, p53 and PKB but not with axin
Keywords: GSK-3; Calpain; p53; Axin; PKB; 14-3-3ζ;
Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2
Keywords: PKB; AKT; CDK; Cancer;
Several agents and pathways regulate lipolysis in adipocytes
Keywords: Lipolysis; Adipose tissue; Intracellular signalling pathways; Hormone-sensitive lipase; Adipose triglyceride lipase; Antilipolysis; ACTH; adrenocorticotrophin hormone; AdPLA; adipose-specific phospholipase A2; Ang II; angiotensin II; ANP; atrial natriuret
Nuclear β-adrenergic receptors modulate gene expression in adult rat heart
Keywords: AC; adenylyl cyclase; ATP; adenosine triphosphate; βAR; β-adrenergic receptor; CAMKII; Ca2+/calmodulin-dependent protein kinase II; DNA; deoxyribonucleic acid; DTT; dithiothreitol; ET-1; endothelin 1; ERK; extracellular signal-regulated kinase; GPCR; G
Ligand-induced internalization of TNF receptor 2 mediated by a di-leucin motif is dispensable for activation of the NFκB pathway
Keywords: ADAM; a disintegrin and metalloproteinase; BSA; bovine serum albumin; CHO-TNFÎ[1-12]; Chinese Hamster Ovary cells transfected with TNFÎ[1-12]; DKO MEF; mouse embryonic fibroblasts from TNFR1-/-/TNFR2-/- mice; EEA1; early endosomal antigen 1;
Forebrain-specific constitutively active CaMKKα transgenic mice show deficits in hippocampus-dependent long-term memory
Keywords: ACSF; artificial cerebrospinal fluid; AMPK; 5Ⲡadenosine monophosphate-activated protein kinase; BDNF; brain-derived neurotrophic factor; CaM; Ca2+/calmodulin; CaMKI; CaM kinase I; CaMKIIα; Ca2+/calmodulin-dependent protein kinase IIα; CaMKIV; CaM kin
Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass
Keywords: 4E-BP1; 4E binding protein 1; 5â²UTR; 5â² untranslated region; AICAR; 5-aminoimidazole-4-carboxamide riboside; AMP; adenosine monophosphate; AMPK; 5â²-AMP-activated protein kinase; AMPK α1â/â; AMPK α1 subunit knockout; AMPKα1â/âα2â/â; A
PKCdelta is a positive regulator of chondrogenesis in chicken high density micromass cell cultures
Keywords: Rottlerin; MEK-ERK; Sox9; shRNA; Cartilage formation; BMP; bone morphogenic protein; BSA; bovine serum albumin; CaM-KIII; calcium/calmodulin dependent protein kinase III; CMF-PBS; calcium/magnesium free PBS; DAG; diacyl-glycerol; DMMB; dimethyl-methylen
Fluorescent adducts formed by reaction of oxidized unsaturated fatty acids with amines increase macrophage viability
Keywords: HHE; 4-hydroxyhexenal; HNE; 4-hydroxynonenal; AA; arachidonic acid; AOP-LDL; arachidonate oxidation product-modified LDL; apo; apolipoprotein; BHT; butylated hydroxytoluene; ESI; electrospray ionization; FBS; fetal bovine serum; isoLG; isolevuglandin; LA;
Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1
Keywords: AMPK; AMP-activated protein kinase; HEK293; human embryo kidney 293 cells; IIS; insulin/insulin-like signaling; IRS; insulin receptor substrate; MAPK; mitogen activated protein kinase; PGC-1α; PPARγ general co-activator 1α; PI3K; phosphoinositide 3-kin
The PKB/FOXO switch in aging and cancer
Keywords: PKB; FOXO; Aging; Cancer; Cell and tissue homeostasis
Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas
Keywords: Cannabinoids; Cannabinoid receptors; Food intake; Obesity; Insulin secretion; Islets of Langerhans; β-cells; AC; adenylate cyclase; ACEA; N-(2-chloroethyl)5,8,11,14-eicosaetraenamide; AEA; N-arachidonoyl ethanolamine; 2-AG; 2-arachidonoyl glycerol; AM251
Mechanisms involved in the enhancement of mammalian target of rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice
Keywords: PKB; protein kinase B; mTOR; mammalian target of rapamycin; GDF-8; growth differentiation factor-8; TGF-β; transforming growth factor-β; 4E-BP1; eukaryotic translation initiation factor 4E-binding protein-1; rpS6; ribosomal protein S6; COX IV; cytochrom
A role of nitric oxide in neurite outgrowth of neuroblastoma cells triggered by mevastatin or serum reduction
Keywords: Neuroblastoma; Nitric oxide; Akt; PKB; Neurite outgrowth; Statin
Azole-based inhibitors of AKT/PKB for the treatment of cancer
Keywords: PKB; AKT; Cancer; SAR studies
Manganese-mediated up-regulation of HIF-1α protein in Hep2 human laryngeal epithelial cells via activation of the family of MAPKs
Keywords: ATF-2; activating transcription factor-2; CHX; cycloheximide; COX-2; cyclooxygenase-2; ECL; enzyme-linked chemiluminescence; ERK-1/2; extracellular-regulated protein kinase-1/2; FBS; fetal bovine serum; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HRE
Inhibition of C5a receptor alleviates experimental CNS lupus
Keywords: SLE; System lupus erythematosus; IC; Immune complex; qRT-PCR; Quantitative RT-PCR; C5aRant; Antagonist of C5aR; PKB; Protein kinase B; CNS; Central nervous system; MAC; Membrane attack complex; Crry; CR1-related protein y; CSF; Cerebrospinal fluid; MRL/lp
Straightforward synthesis of novel Akt inhibitors based on a glucose scaffold
Keywords: Sugar phosphoramidates; Enzyme inhibitors; PKB; Glycolipid analogues; Cyclitol analogues; Glucose;
Refining the minimal sequence required for ERK1/2-dependent poly-ubiquitination and proteasome-dependent turnover of BIM
Keywords: BIM, Bcl-2-interacting mediator of cell death; BOP, BH3-only protein; Cbl, Casitas B-lineage lymphoma oncogene; DLC1, dynein light chain 1; ERD, ERK1/2-responsive domain; ERK1/2, extracellular signal-regulated kinases 1 and 2; MEK, MAPK or ERK kinase; PKB
Ras signalling regulates differentiation and UCP1 expression in models of brown adipogenesis
Keywords: AEBP1; AE-binding protein 1; C/EBP; CCAAT/enhancer-binding protein; CS; citrate synthase; DMEM; Dulbecco's Modified Eagle's Medium; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated kinase; FABP4; fatty acid-binding protein 4; FBS; foetal bovi
Coupling of mitochondria to store-operated Ca2+-signaling sustains constitutive activation of protein kinase B/Akt and augments survival of malignant melanoma cells
Keywords: Calcium; Mitochondrium; PKB; Melanoma; Apoptosis;
Intracellular Ca2+ storage in health and disease: A dynamic equilibrium
Keywords: Aβ; amyloid-β; AD; Alzheimer's disease; ADPKD; autosomal dominant polycystic kidney disease; APP; amyloid precursor protein; Bax; Bcl-2-associated Xprotein; BI-1; Bax Inhibitor-1; [Ca2+]cyt; cytosolic Ca2+ concentration; [Ca2+]ER; endoplasmic-reticulum
Aminofurazans as potent inhibitors of AKT kinase
Keywords: AKT; PKB; Kinase inhibitor; Serine/threonine kinase
Acid–base behavior of 3-aminoquinoline in its ground and excited states
Keywords: Fluorescence; Photophysics; pKb; Nafion
Phosphatidylinositol-3-Kinase/Akt Signaling Pathway and Kidney Cancer, and the Therapeutic Potential of Phosphatidylinositol-3-Kinase/Akt Inhibitors
Keywords: kidney; carcinoma; renal cell; D 21266; 1-phosphatidylinositol 3-kinase; mTOR protein; 17-HWT; 17-hydroxy-wortmannin; APC; alkylphosphocholine; ERK; extracellular regulated kinase; GSK3; glycogen synthase kinase-3; HIF; hypoxia-inducible factor; IC50; hal
Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: Implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration
Keywords: PH; partial hepatectomy; SGK1; serum and glucocorticoid-inducible protein kinase1; PKB; protein kinase B; ERK; extracellular signal-regulated kinase; MEK; mitogen-activated protein kinase kinase; GST; glutathione S-transferase; NF-κB; MAP kinase; Liver r
Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis
Keywords: CTMP; PKB; Mitochondria; Apoptosis
Cell death in the injured brain: Roles of metallothioneins
Keywords: ADP; adenosine diphosphate; AIF; apoptosis-inducing factor; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolyl-propionic acid; Apaf-1; apoptotic protease-activating factor 1; Atg; autophagy gene; Bak; Bcl-2-homologous antagonist/killer; Bax; Bcl-2-associated
Protein kinase CβI interacts with the β1-adrenergic signaling pathway to attenuate lipolysis in rat adipocytes
Keywords: β-AR; β-adrenergic receptor; PKA; protein kinase A; PKB; protein kinase B; PKC; protein kinase C; cPKC; conventional PKC; nPKC; novel PKC; aPKC; atypical PKC; PI3K; phosphatidylinositol 3-kinase; HSL; hormone-sensitive lipase; PDE3B; phosphodiesterase 3
Differences in endothelin receptor types in the vasculature of Bothrops jararaca (Viperidae) and Oxyrhopus guibei (Colubridae) snakes
Keywords: Ach; acetylcholine; AI; angiotensin I; Bj; Bothrops jararaca or B. jararaca; CCRC; cumulative concentration-response curve; ETA; endothelin receptor type A; ETB; endothelin receptor type B; ETs; endothelins; ET-1; endothelin-1; Emax; maximum effect; l-N
The anti-apoptotic activity associated with phosphatidylinositol transfer protein α activates the MAPK and Akt/PKB pathway
Keywords: PI-TP; phosphatidylinositol transfer protein; PI; phosphatidylinositol; PC; phosphatidylcholine; PLA; phospholipase A; MAPK; mitogen-activated protein kinase; ERK; extracellular signalling related kinase; IAP; inhibitor of apoptosis protein; PKB; protein
Linker region of Akt1/protein kinase Bα mediates platelet-derived growth factor-induced translocation and cell migration
Keywords: PDGF; platelet-derived growth factor; PKB; protein kinase B; PI3K; phosphatidylinositol 3-kinase; MEF; mouse embryo fibroblast; P-Rex1; PIP3-dependent Rac exchanger1; Girdin; girders of actin filaments; Migration; PI3K; Akt/PKB; Linker region; PDGF;
In vitro and in vivo bioactivity of recombinant canine hepatocyte growth factor
Keywords: HGF; c-MET; PKB; ERK1/2; PCNA; Partial hepatectomy; Liver regeneration; Dogs
The docking properties of SHIP2 influence both JIP1 tyrosine phosphorylation and JNK activity
Keywords: SHIP2; SH2-domain containing inositol polyphosphate 5-phosphatase 2; JNK; c-Jun N-terminal kinase; JIP1; JNK-interacting protein 1; MLK3; mixed-lineage kinase3; MAPK; mitogen-activated protein kinase; MKK7; MAPK kinase 7; DLK; dual leucine zipper-bearing
The involvement of phosphatidylinositol 3-kinase in gonadotropin-releasing hormone-induced gonadotropin α- and FSHβ-subunit genes expression in clonal gonadotroph LβT2 cells
Keywords: PKB; PI3K; ERK; LβT2; Gonadotroph; Gonadotropin
Serine 396 of PDK1 is required for maximal PKB activation
Keywords: PDK1; PKB; Akt; Protein phosphorylation; Signal transduction
The nerve growth factor and its receptors in airway inflammatory diseases
Keywords: ADAM; a disintegrin and metalloprotease domain; AP-1; activating protein 1; AP-2; clathrin adaptative protein-2; APPL; amyloid precursor protein-like; ARMS; ankyrin repeat-rich membrane spanning; BDNF; brain-derived neurotrophic factor; bFGF; basic fibrob
Differential activation of CREB by Akt1 and Akt2
Keywords: Akt1; Akt2; PKB; CREB; Gene expression; Regulation;
Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes
Keywords: Insulin signaling; Insulin resistance; Liver; Hepatocytes; PKB; Akt; mTOR; Fatty acid; Palmitate; Metformin
Pirfenidone inhibits TGF-β expression in malignant glioma cells
Keywords: boc-RVRR-amc; butoxycarbonyl-Arg-Val-Arg-Arg-7-amido-4-methylcoumarine; dec-RVKR-cmk; decanoyl-Arg-Val-Lys-Arg-chloromethylketone; DMEM; Dulbecco's modified Eagle's medium; FCS; fetal calf serum; LDH; lactate dehydrogenase; LAP; latency associated pro
Protein kinase C-dependent antilipolysis by insulin in rat adipocytes
Keywords: β-AR; β-adrenergic receptor; α-AR; α-adrenergic receptor; PKA; protein kinase A; PKC; protein kinase C; PKB; protein kinase B; PDK; phosphoinositide-dependent protein kinase; PI3K; phosphatidylinositol 3-kinase; PIP3; phosphatidylinositol 3,4,5-tripho
Rotenone-induced neurotoxicity of THP-1 cells requires production of reactive oxygen species and activation of phosphatidylinositol 3-kinase
Keywords: PD; Parkinson's disease; ROS; reactive oxygen species; PI3K; phosphatidylinositol 3-kinase; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; PKB; protein kinase B; COX-2; cyclooxygenase-2; PGE2; prostaglandin E2; CM; conditioned media
Synthesis and structure–activity relationship of 3,4′-bispyridinylethylenes: Discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer
Keywords: Inhibitors of Akt; Akt1; Akt2; Akt3; PKA; PKB; protein kinase B; GSK3; FL5.12-Akt1; X-ray; Anticancer; Apoptosis; Antitumor; Pharmacokinetics; Kinase inhibitors; Structure-based design
Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCα
Keywords: PI 3-kinase; phosphoinositide 3-kinase; PKB; protein kinase B; PDK-1; phosphoinositide-dependent kinase-1; PKC; protein kinase C; mTOR; mammalian target of rapamycin; c48/80; compound 48/80; BAPTA; bis-(o-aminophemoxy)-ethane-N,N,Nâ²,Nâ²-tetraacetic aci
Pertussis toxin promotes macrophage survival through inhibition of acid sphingomyelinase and activation of the phosphoinositide 3-kinase/protein kinase B pathway
Keywords: PTX; Pertussis toxin; BMDM; bone marrow-derived macrophages; C1P; ceramide 1-phosphate; C2-; acetyl; M-CSF; macrophage colony stimulating factor; MAPK; mitogen-activated protein kinase; ERK; extracellular regulated kinase; MEK; MAPK/ERK kinase; MTS; [3-(4