کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1390640 983117 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Straightforward synthesis of novel Akt inhibitors based on a glucose scaffold
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Straightforward synthesis of novel Akt inhibitors based on a glucose scaffold
چکیده انگلیسی
Glucose-based analogues of phosphatidylinositol 3-phosphate were straightforwardly synthesised from 2,3,4,6-tetra-O-acetyl-d-glucosyl bromide as protein kinase B (PKB/Akt) inhibitors. β-d-Glucuronyl diethyl phosphoramidate was identified as a promising hit through biological screening in two different cellular systems. In addition, RNA interference experiments (siRNA) provide evidence of the ability of the compound to exert biological effects specifically through Akt signalling.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 345, Issue 10, 2 July 2010, Pages 1291-1298
نویسندگان
, , , , , , ,