کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8262312 | 1534836 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acute extracellular matrix, inflammatory and MAPK response to lengthening contractions in elderly human skeletal muscle
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
IL-13MCP-1DAPIECMp70S6KIL-4PKBIL-8MFIIFNγCXCLIP-10FBSSMADJnkIL-7CCL2IL-6VASMyHCI-TACInterleukin 9TGF-βribosomal protein S6 kinase beta-1TNFαmothers against decapentaplegic homologPBSNF-κBTGF-βRIImonokine induced by gamma interferon4′,6-diamidino-2-phenylindole - 4 '، 6-دیامیدینو-2-فنیلینولBSA - BSAc-Jun N-terminal kinase - C-Jun N-terminal kinaseERK1/2 - ERK1 / 2IL-1b - IL-1BMAPK - MAPKMIG - MEbovine serum albumin - آلبومین سرم گاوSTAT - آمارinflammation - التهاب( توروم) Lengthening contractions - انقباضات طولانی مدتCSA - ایالات مؤتلفهٔ آمریکاinterleukin 1 beta - اینترلوکین 1 بتاInterleukin 4 - اینترلوکین 4interleukin 6 - اینترلوکین 6Interleukin 7 - اینترلوکین 7Interleukin 8 - اینترلوکین 8Muscle regeneration - بازسازی عضلاتtransforming growth factor-beta - تبدیل فاکتور رشد بتاtumor necrosis factor alpha - تومور نکروز عامل آلفاMyosin heavy chain - زنجیره سنگین میوزینAging - سالخوردگیfetal bovine serum - سرم جنین گاوextracellular-signal regulated kinase - سیگنال تنظیم شده سیگنال خارج سلولیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیnuclear factor kappa-light-chain-enhancer of activated B cells - فاکتور هسته ای kappa-light-chain-enhancer از سلول های B فعال شده استPhosphate buffered saline - فسفات بافر شورExtracellular matrix - ماتریکس خارج سلولیcross-sectional area - مقطع عرضیvisual analog scale - مقیاس آنالوگ بصریmonocyte chemoattractant protein 1 - پروتئین cheoattractant monocyte 1protein kinase B - پروتئین کیناز Bmitogen activated protein kinase - پروتئین کیناز فعال Mitogen فعال استchemokine (C-C motif) ligand 2 - کیموکین (C-C motif) لیگاند 2Interferon gamma - گاما اینترفرون
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
To uncover potential factors that may be involved in the impaired regenerative capacity of aged skeletal muscle, we comprehensively assessed the molecular stress response following muscle damage in old and young individuals. 10 young (22.7â¯Â±â¯2.25â¯yrs) and 8 physically active old (70.9â¯Â±â¯7.5â¯yrs) subjects completed a bout of 300 lengthening contractions (LC), and muscle biopsies were taken pre-exercise and at 3, 24, and 72â¯h post-LC. Both age groups performed the same amount of work during LC, with the old group displaying a resistance to LC-induced fatigue during the exercise. Muscle damage was evident by soreness and losses in isokinetic force and power production, though older subjects experienced reduced force and power losses relative to the young group. The acute extracellular matrix (ECM) response was characterized by substantial increases in the glycoproteins tenascin C and fibronectin in the young, which were blunted in the old muscle following damage. Old muscle displayed a generally heightened and asynchronous inflammatory response compared to young muscle, with higher expression of MCP-1 that appeared at later time points, and increased NF-κb activity. Expression of the stress-related MAPKs P38 and JNK increased only in the old groups following muscle damage. In summary, aberrations appear in the inflammatory, ECM and MAPK responses of aged skeletal muscle following damaging LC, each of which may individually or collectively contribute to the deterioration of muscle repair mechanisms that accompanies aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 106, June 2018, Pages 28-38
Journal: Experimental Gerontology - Volume 106, June 2018, Pages 28-38
نویسندگان
Jacob R. Sorensen, Caitlin Skousen, Alex Holland, Kyle Williams, Robert D. Hyldahl,