Keywords: Anti-inflammatory cytokines; Decoy receptors; Inhibitory factors; Innate immunity; Resolution of inflammation; Stress hormones; Toll-like receptor signalling; ACTH; adrenocorticotropic hormone; AP1; activator protein 1; A2M; alpha-2-macroglobulin; CCP; co
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Keywords: α-Syn; α-synuclein; AD; Alzheimer's disease; BP; Biological Process; CAMS; Chinese Academy of Medical Sciences; CAPS; calcium-dependent activator of secretion; CC; Cellular component; CCK; Cell counting kit; DA; dopamine; DAVID; Database for annotation,
Keywords: PRR; pattern recognition receptor; PAMP; pathogen-associated molecular pattern; DAMP; danger-associated molecular pattern; NLRP3; NOD-, LRR- and pyrin domain-containing 3; TLR; toll-like receptor; CLR; C-type lectin receptor; NLR; NOD-like receptor; RIG-I
Keywords: Ginger; Multiple sclerosis; Experimental autoimmune encephalomyelitis; Therapeutic potentials; AP-1; Activator protein 1; APCs; Antigen-presenting cells; ASC; apoptosis speck-like protein containing CARD; BAFF; B cell-activating factor belonging to the TN
Keywords: AP-1; activator protein 1; APC; antigen-presenting cells; ARE; AU-rich element; ASK; Apoptosis Signal regulating Kinase; ATF-2; Activating Transcription Factor 2; CRE; Cyclic AMP Responsive Element; CBP; CREB binding protein; CsA; ciclosporin A; ERK; Extr
Keywords: Bioactive fragments; Cryptome; Extracellular matrix; Matricryptins; Proteases; ADAM; A disintegrin and metalloproteinase; ADAMTS; A disintegrin and metalloproteinase with thrombospondin motif; ATP; Adenosine triphosphate; BMP-1; Bone morphogenetic protein
Keywords: Clarithromycin (PubChem CID: 84029); poly I:C (PubChem CID: 32744); Pam3CSK4 (PubChem CID: 130704); CAM; clarithromycin; CARD; caspase activation and recruitment domain; CCL5; chemokine (C-C motif) ligand 5; CF; cystic fibrosis; COPD; chronic obstructive
Keywords: AP-1; activator protein; CD14; cluster of differentiation 14; ERK; extracellular signal-regulated kinase; IκBα; inhibitor of NFκB; IKK; inhibitor of NFκB kinase; IRAK; IL-1 receptor-associated kinase; IRF; interferon regulatory factor; JNK; c-Jun N-te
Keywords: AKT; protein kinase B; ATM; ataxia-telangiectasia mutated; ELISA; enzyme-linked immunosorbent assay; EMT; epithelial-mesenchymal transition; ERK; extracellular signal-regulated kinase; GSK; glycogen synthase kinase; hSAEC; human small airway epithelial
Keywords: I/R; ischemia/reperfusion; ECs; endothelial cells; TNF-α; tumor necrosis factor α; DAMPs; danger-associated molecular patterns; TLRs; toll-like receptors; IRF; interferon regulatory factor; TRAF; TNF receptor-associated factors; ECM; extracellular matri
Keywords: CD 14; cluster determinant 14; TLR; toll like receptor; TNF; tumor necrotic factor; EGFR; epidermal growth factor receptor; ODE; ordinary differential equation; PCA; principal component analysis; NIK; NFκB-inducing kinase; MKK; mitogen kinase kinases; PI
Keywords: AIM2; absent in melanoma 2; AP-1; activating protein-1; APOBEC; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like; AZT; azidothymidine; CCCR5; C-C chemokine receptor type 5; CDK1; cyclin-dependent kinase 1; CXCR4; C-X-C chemokine receptor t
Keywords: AP-1; jun proto-oncogene; BAI3; brain-specific angiogenesis inhibitor 3; CADM2; cell adhesion molecule 2; CAGE; cap analysis of gene expression; cDNA; DNA complementary to RNA; ChIP; chromatin immunoprecipitation; FGF14; fibroblast growth factor 14; GADD4
Keywords: ACTDs; autoimmune connective tissue diseases; SLE; systemic lupus erythematosus; RA; rheumatoid arthritis; SSc; systemic sclerosis; SS; Sjögren's syndrome; MCTD; mixed connective tissue disease; TLRs; IL-1R-like receptors; DAMPs; danger-associated molecu
Keywords: Abl; Abelson leukemia proto-oncogene; ADAP; adhesion and degranulation promoting adapter protein (Fyb, SLAP-130); Asc; apoptosis-associated speck-like protein containing a CARD; BCR; B-cell receptor; C3G; Crk SH3 domain-binding guanine nucleotide exchange
Dexmedetomidine mitigate acute lung injury by inhibiting IL-17-induced inflammatory reaction
Keywords: IL-17; interleukin-17; TNF; tumor necrosis factor; Dex; dexmedetomidine; TRAF; tumor necrosis factor receptor-associated factor; Dexmedetomidine; IL-17; Lung injury; Inflammation; NF-κB;
TNF receptor associated factor 5 controls oncostatin M-mediated lung inflammation
Keywords: Oncostatin M; Lung endothelial cell; Lung stromal/fibroblast cells; VCAM-1; Traf5; OSM; oncostatin M; TRAF; TNF receptor associated factor; IBD; inflammatory bowel disease; MLF; mouse lung stromal/fibroblast cell; DMEM; Dulbecco's Modified Eagle medium; O
Upregulation of miR-215 exerts neuroprotection effects against ischemic injury via negative regulation of Act1/IL-17RA signaling
Keywords: Act1; nuclear factor activator 1; CCA; common carotid artery; ECA; external carotid artery; FITC; fluorescein isothiocyanate; HEK293T; human embryonic kidney 293T; ICA; internal carotid artery; IL-17RA; interleukin-17 receptor A; JNK; c-JuneN-terminal kin
Seeing is understanding: Salmonella's way to penetrate the intestinal epithelium
Keywords: ARNO; adenosine diphosphate (ADP) ribosylation factor nucleotide exchange factor; BMP; bone morphogenetic protein; Cdc42; cell division control protein 42 homolog; CFU; colony forming unit; EGF; epithelial growth factor; Ets; E26 transformation-specific;
Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease
Keywords: AChE; acetylcholine esterase; AD; Alzheimer's disease; AP1; activator protein 1; APP; amyloid precursor protein; Aβ; amyloid beta; BACE1; β-site of APP cleaving enzyme; Bax; Bcl-2-associated X protein; BBB; blood-brain barrier; Bcl-2; B-cell lymphoma
Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis
Keywords: atherosclerosis; drug development; immunology; inflammation; nanotechnology; Apoe; apolipoprotein E; BMDM; bone marrow-derived macrophage; CVD; cardiovascular disease; DC; dendritic cell; NF-κB; nuclear factor kappa-light-chain-enhancer of activated B ce
Regulation of inflammation by β-arrestins: Not just receptor tales
Keywords: βarr; β-arrestin; IL; interleukin; IκBα; inhibitor α of NFκB; IKK; IκB kinase; MEF; mouse embryo fibroblast; LPA; lysophosphatidic acid; TLR4; Toll-like receptor-4; TNF; tumor necrosis factor; TNFR1; TNF receptor-1; TRAF; TNFR-associated factor; 7T
NOD1 and NOD2: Molecular targets in prevention and treatment of infectious diseases
Keywords: AMP; antimicrobial peptide; CARD; caspase activation and recruitment domain; CMV; cytomegalovirus; DC; dendritic cell; ER; endoplasmic reticulum; GlcNAc; N-acetyl-d-glycosamine; GMDP; glucosaminyl muramyl dipeptide (N-acetyl-d-glucosaminyl-N-acetyl-d-mura
Promising new therapeutic targets for regulation of inflammation and immunity: RING-type E3 ubiquitin ligases
Keywords: ALS; amyotrophiclateral sclerosis; AP-1; activator protein 1; APC; antigen-presenting cell; APC/C; anaphase promoting complex/cyclosome; CLR; C-type lectin receptor; CRL; Cullin RING ligase; ERK; extracellular signalregulated kinase; FANC; Fanconi anemia
Rig-I is involved in inflammation through the IPS-1/TRAF6 pathway in astrocytes under chemical hypoxia
Keywords: RIG-I; retinoic acid-inducible gene I; IPS-1; interferon-β promoter stimulator-1; TRAF; TNF receptor-associated factor; PRRs; pattern recognition receptors; TLRs; toll-like receptors; NLRs; NOD-like receptors; RLRs; RIG-like receptors; MDA5; melanoma dif
Helicobacter pylori induces direct activation of the lymphotoxin beta receptor and non-canonical nuclear factor-kappa B signaling
Keywords: CagA; cytotoxin-associated gene A; cagPAI; cytotoxin-associated gene pathogenicity island; cIAP; cellular inhibitor of apoptosis protein; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HBV; hepatitis B virus; HCV; hepatitis C virus; IκBα; NF-kappa-B i
Regulation of cancer immune escape: The roles of miRNAs in immune checkpoint proteins
Keywords: Immune checkpoint proteins (ICPs); miRNAs; Cancer immune escape; Antigen-MHC; antigen-major histocompatibility complex; ICPs; immune checkpoint proteins; 3â²UTR; 3â² untransltated region; PD-1; programmed cell death protein; Tregs; regulatory T cells; H
Neuregulin 1 discovered as a cleavage target for the HCV NS3/4A protease by a microfluidic membrane protein array
Keywords: HCV; hepatitis C virus; HCC; hepatocellular carcinoma; NS; nonstructural protein; TIR; toll/interleukin 1 receptor; TRIF; (TIR)-domain-containing adapter-inducing interferon-β; IIR; innate immune response; RIG-I; retinoic acid inducible gene; MAVS; mitoc
Madecassoside protects BV2 microglial cells from oxygen-glucose deprivation/reperfusion-induced injury via inhibition of the toll-like receptor 4 signaling pathway
Keywords: COX-2; cyclooxygenase-2; DMSO; dimethyl sulfoxide; IRAK; IL-1R-associated kinase; IKK; IκB kinase; IL; interleukin; iNOS; inducible nitric oxide synthase; I/R; ischemia/reperfusion; IRF; interferon regulatory factor; MA; madecassoside; MyD88; myeloid dif
MicroRNA regulation of Toll-like receptor signaling pathways in teleost fish
Keywords: MicroRNA; Toll-like receptors; Fish; Immune response; AP-1; activator protein; CCR3; CC chemokine receptor 3; CDS; coding region; COX2; cyclooxygenase-2 enzyme; CQ; chloroquine; ER; endoplasmic reticulum; Flg 22; amino-terminal fragment of flagellin; GCRV
Ca2+ signaling and Src-kinases-controlled cellular functions
Keywords: Ca2+ channels; Cell signaling; Phosphatases; Receptors; Src-family kinases; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxyli
Smac mimetic induces an early wave of gene expression via NF-κB and AP-1 and a second wave via TNFR1 signaling
Keywords: Smac mimetics; Microarray; Breast cancer; Cell death; IAP proteins; Cytokines; AP-1; activator protein 1; BIR; baculovirus IAP repeat; cIAP; cellular IAP; DEG; differential regulated gene; FADD; FAS-associated protein with death domain; FCS; fetal calf se
Flaviviridae virus nonstructural proteins 5 and 5A mediate viral immune evasion and are promising targets in drug development
Keywords: AAF; IFN-α-activated factor; ATA; Aurintricarboxylic acid; BDV; border disease virus; BPgV; GBV-D; BVDV-1; bovine viral diarrhea virus-1; C; capsid protein; CLRs; C-type lectin receptors; Core; core protein; CSFV; classical swine fever virus; DENV; dengu
Research paperSTRAP positively regulates TLR3-triggered signaling pathway
Keywords: STRAP; serine/threonine kinase receptor associated protein; TLR; Toll-like receptor; IFN; interferon; IRF; IFN regulatory factor; TBK1; TANK binding kinase 1; TRAF; TNF receptor associated factor; TAK1; transforming growth factor β-activated kinase 1; ST
Characterization of non-lethal West Nile Virus (WNV) infection in horses: Subclinical pathology and innate immune response
Keywords: Flavivirus; Arbovirus; Equine; Interferons; Innate immune response; CNS; central nervous system; CXCL10; chemokine (C-X-C motif) ligand 10; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HE; hematoxylin and eosin; HIF-1α; hypoxia inducible factor 1α; IF
The good and the bad faces of STAT1 in solid tumours
Keywords: BAD; Bcl2-associated agonist of cell death; Bcl; B-cell lymphoma; CD; cluster of differentiation; CDK; cyclin-dependent kinase; CTL; cytotoxic T lymphocyte; CUG; cancer upregulated gene; CXCL; C-X-C motive ligand; DC; dendritic cells; DAMP; danger-associa
The anticancer functions of RIG-I-like receptors, RIG-I and MDA5, and their applications in cancer therapy
Keywords: 5â²PP; 5â²-diphosphate; 5â²ppp; 5â²triphosphorylated; Bcl2; B-cell lymphoma-2; BIRC3; baculoviral IAP repeat-containing 3; CARDs; caspase activation and recruitment domains; CRC; colorectal cancer; CTD; C-terminal domain; CTLs; cytotoxic T lymphocytes
Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-κB activation and leads to incontinentia pigmenti
Keywords: Incontinentia pigmenti; IKBKG; NF-κB essential modulator; nuclear factor κB; linear ubiquitin assembly complex; linear ubiquitination; SHANK-associated RH domain-interacting protein; EDA-ID; Anhidrotic ectodermal dysplasia with immunodeficiency; HA; H
Glycyrrhetinic acid attenuates lipopolysaccharide-induced fulminant hepatic failure in d-galactosamine-sensitized mice by up-regulating expression of interleukin-1 receptor-associated kinase-M
Keywords: LPS; lipopolysaccharide; D-GalN; d-galactosamine; ALT; alanine aminotransferase; AST; aspartate aminotransferase; TNF-α; tumor necrosis factor-α; TLR4; toll like receptor 4; IRAKs; interleukin-1 receptor-associated kinases; MAPKs; mitogen-activated prot
New insight into the interaction of TRAF2 C-terminal domain with lipid raft microdomains
Keywords: TRAF; TNF receptor-associated factor; JNK; c-Jun N-terminal kinase; LUV; large unilamellar vesicles; GUVs; giant unilamellar vesicles; BBMs; brush border membranes; DOPC; 1,2-dioleoyl-sn-glycero-3-phosphocholine; POPC; 1-palmitoyl-2-oleoyl-sn-glycero-3-ph
Functional motifs responsible for human metapneumovirus M2-2-mediated innate immune evasion
Keywords: hMPV; M2-2 motif; TRAF; MAVS; Innate immune response;
Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling
Keywords: Ubiquitin; Innate immunity; TNF; TLR3; NOD1; LUBAC; AMSH-LP; AMSH-like protein; λ-PPase; bacteriophage λ protein phosphatase; BMDM; bone marrow-derived macrophages; JNK; c-Jun N-terminal kinase; cIAP; cellular Inhibitor of Apoptosis; DUB; deubiquitylase
Identification of an S100A8 Receptor Neuroplastin-β and its Heterodimer Formation with EMMPRIN
Keywords: AD; atopic dermatitis; EMMPRIN; extracellular matrix metalloproteinase inducer; ERK; extracellular signal-regulated kinase; NPTN; neuroplastin; RAGE; receptor for advance glycation end-products; TLR; Toll-like receptor; TNCB; trinitrochlorobenzene; TNF; t
Staphylococcal LTA-Induced miR-143 Inhibits Propionibacterium acnes-Mediated Inflammatory Response in Skin
Keywords: IL-6; interleukin-6; LTA; lipoteichoic acid; miRNAs; microRNAs; SECM; S. epidermidis culture medium; TNF; tumor necrosis factor; TRAF; TNF receptor-associated factor; TLR; toll-like receptor; OxPAPC; oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phospho
The Paracaspase MALT1
Keywords: NF-κB signaling; Protease; Caspase; Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1); ABC; activated B cell-like; ABC-DLBCL; activated B cell-like diffuse large B cell lymphoma; Ac; acetyl; ALL; acute lymphomblastic leukemia; AM
The immune signaling pathways of Manduca sexta
Keywords: Insect immunity; RNA-Seq; Transcriptome; Gene annotation; Expression profiling; Atg; autophagy-related protein; aPKC; atypical protein kinase C; CF; control fat body; CH; control hemocytes; IF; induced fat body; IH; induced hemocytes; Deaf; deformed epide
γ-Glutamyl cysteine and γ-glutamyl valine inhibit TNF-α signaling in intestinal epithelial cells and reduce inflammation in a mouse model of colitis via allosteric activation of the calcium-sensing receptor
Keywords: CaSR; calcium-sensing receptor; GPCR; G-protein-coupled receptor; IBD; inflammatory bowel disease; CD; Crohn's disease; UC; ulcerative colitis; γ-EC; γ-glutamyl cysteine; γ-EV; γ-glutamyl valine; GRK; GPCR kinase; TRAF; TNF-receptor-associated factor;
Boerhavia diffusa L. ethanol extract suppresses inflammatory responses via inhibition of Src/Syk/TRAF6
Keywords: Bd-EE; Boerhavia diffusa L. ethanol extract; HPLC; high performance liquid chromatography; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; TLR; Toll-like receptor (TLR); NF-κB; nuclear factor-κB; AP-1; Activat
The Nuclear Factor κB pathway: A link to the immune system in the radiation response
Keywords: Nuclear Factor κB; Immune system; Cellular radiation response; Linear energy transfer; Bystander effect; Chemokines; A20 (TNFAIP3); tumor necrosis factor inducible protein 3; ARD; ankyrin repeat domain; ATM; ataxia telangiectasia mutated protein; β-TrCP
The functions of the avian receptor activator of NF-κB ligand (RANKL) and its receptors, RANK and osteoprotegerin, are evolutionarily conserved
Keywords: Aa; amino acids; APC; antigen presenting cells; BMDC; bone marrow-derived dendritic cells; BMM; BM-macrophages; Ca2+; calcium ions; CRD; cysteine rich domain; Ct; cycle threshold; DC; dendritic cells; DD; death domain; OPG; osteoprotegerin; PKC; protein k