کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8304498 | 1538409 | 2016 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Proteases decode the extracellular matrix cryptome
ترجمه فارسی عنوان
پروتئازها رمزگشایی ماتریس خارج سلولی را رمزگشایی می کنند
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کلمات کلیدی
ECMMatricryptinsmammalian tolloidmTldBMP1BMP-1SPARCTRAFADAMTSEGFMMPADAM - آدامAdenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPa disintegrin and metalloproteinase - تخریب و متالوپروتئینازCub - تولهTIMP - زمانepidermal growth factor - عامل رشد اپیدرمیFibronectin - فیبرونکتینExtracellular matrix - ماتریکس خارج سلولیmatrix metalloproteinase - ماتریکس متالوپروتئینازTissue inhibitor of metalloproteinases - مهار کننده های متالوپروتئینازهای بافتProteases - پروتئازsecreted protein acidic and rich in cysteine - پروتئین اسیدی و غنی از سیتین را ترشح می کندbone morphogenetic protein-1 - پروتئین مورفوژنیک استخوان 1
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
The extracellular matrix is comprised of 1100 core-matrisome and matrisome-associated proteins and of glycosaminoglycans. This structural scaffold contributes to the organization and mechanical properties of tissues and modulates cell behavior. The extracellular matrix is dynamic and undergoes constant remodeling, which leads to diseases if uncontrolled. Bioactive fragments, called matricryptins, are released from the extracellular proteins by limited proteolysis and have biological activities on their own. They regulate numerous physiological and pathological processes such as angiogenesis, cancer, diabetes, wound healing, fibrosis and infectious diseases and either improve or worsen the course of diseases depending on the matricryptins and on the molecular and biological contexts. Several protease families release matricryptins from core-matrisome and matrisome-associated proteins both in vitro and in vivo. The major proteases, which decrypt the extracellular matrix, are zinc metalloproteinases of the metzincin superfamily (matrixins, adamalysins and astacins), cysteine proteinases and serine proteases. Some matricryptins act as enzyme inhibitors, further connecting protease and matricryptin fates and providing intricate regulation of major physiopathological processes such as angiogenesis and tumorigenesis. They strengthen the role of the extracellular matrix as a key player in tissue failure and core-matrisome and matrisome-associated proteins as important therapeutic targets.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 122, March 2016, Pages 300-313
Journal: Biochimie - Volume 122, March 2016, Pages 300-313
نویسندگان
Sylvie Ricard-Blum, Sylvain D. Vallet,