کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1936006 1050680 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of AMP-activated protein kinase in autophagy and proteasome function
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Role of AMP-activated protein kinase in autophagy and proteasome function
چکیده انگلیسی

In this work, we have examined the possible role of AMP-activated protein kinase (a key energy sensor) in regulating intracellular protein degradation. We have found that AICAR, a known activator of AMPK, has a dual effect. On one hand, it inhibits autophagy by a mechanism independent of AMPK activity; AICAR decreases class III PI3-kinase binding to beclin-1 and this effect counteracts and reverses the known positive effect of AMPK activity on autophagy. On the other hand, AICAR inhibits the proteasomal degradation of proteins by an AMPK-dependent mechanism. This is a novel function of AMPK that allows the regulation of proteasomal activity under conditions of energy demand.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 369, Issue 3, 9 May 2008, Pages 964–968
نویسندگان
, , , , , , ,