Keywords: پرورش جداسازی; ANOVA; analysis of variance; BrdU; 5-bromo-2â²-deoxyuridine; CFR; conditioned freezing response; GH; Group-housed; HPA; hypothalamic pituitary-adrenal axis; NeuN; neuronal nuclei; NOD; novel object discrimination; PFC; prefrontal cortex; SI; social isola
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Keywords: پرورش جداسازی; Schizophrenia; Isolation rearing; Early antipsychotic intervention; Prepulse inhibition; Dopamine efflux;
Keywords: پرورش جداسازی; Adolescence; Social stress; Play fighting; Social interaction; Isolation rearing; Social isolation; Social defeat; Hypothalamic-pituitary-adrenal axis; Corticosterone; Medial prefrontal cortex; Anxiety; Depression; Addiction; Substance abuse; Self-adminis
Keywords: پرورش جداسازی; Prepulse inhibition; Domoic acid; Isolation rearing; Animal models; Schizophrenia; Neurodevelopmental disorders;
Keywords: پرورش جداسازی; IR, Isolation rearing; RHA-I, Roman high-avoidance rats; RLA-I, Roman low-avoidance rats; PPI, Prepulse inhibition; MWM, Morris water mazeRoman high- and low-avoidance rats; Genetically-based rat model; Schizophrenia; Isolation rearing; Prepulse inhibitio
Keywords: پرورش جداسازی; Latent inhibition; Attentional processing; Domoic acid; Isolation rearing; Schizophrenia; Animal models;
Epigenetic regulation of dorsal raphe GABAB1a associated with isolation-induced abnormal responses to social stimulation in mice
Keywords: پرورش جداسازی; Isolation rearing; DNA methylation; Histone acetylation; GABAB receptor; Dorsal raphe nucleus; Social stimulation
DNA methylation of the GC box in the promoter region mediates isolation rearing-induced suppression of srd5a1 transcription in the prefrontal cortex
Keywords: پرورش جداسازی; DNA methylation; Isolation rearing; Luciferase assay; Transcription factor;
Targeting neurosteroid synthesis as a therapy for schizophrenia-related alterations induced by early psychosocial stress
Keywords: پرورش جداسازی; 5α-Reductase; Isolation rearing; Sensorimotor gating; Neurosteroids; Schizophrenia; Prepulse inhibition;
Effects of REM sleep deprivation on sensorimotor gating and startle habituation in rats: Role of social isolation in early development
Keywords: پرورش جداسازی; Isolation rearing; Prepulse inhibition; REM sleep deprivation; Schizophrenia; Startle habituation;
ReviewForebrain gene expression predicts deficits in sensorimotor gating after isolation rearing in male rats
Keywords: پرورش جداسازی; Catechol-O-methyltransferase; Isolation rearing; Medial prefrontal cortex; Nucleus accumbens; Prepulse inhibition; Schizophrenia;
Isolation rearing reduces mechanical allodynia in a mouse model of chronic inflammatory pain
Keywords: پرورش جداسازی; Isolation rearing; Freund's complete adjuvant (FCA); Mechanical allodynia; Thermal hyperalgesia; Serotonin (5-HT)1A receptor
Social isolation produces anxiety-like behaviors and changes PSD-95 levels in the forebrain
Keywords: پرورش جداسازی; Isolation rearing; Anxiety; Novelty-induced hypophagia; PSD-95; Synapse;
Isolation rearing as a preclinical model of attention/deficit-hyperactivity disorder
Keywords: پرورش جداسازی; Isolation rearing; Locomotor activity; Methylphenidate; Dopamine transporter; Attention-deficit/hyperactivity disorder; Rat
Environmental enrichment with nesting material accelerates wound healing in isolation-reared rats
Keywords: پرورش جداسازی; Environmental enrichment; Isolation rearing; Wound healing; Bedding; Nesting
Isolation rearing attenuates social interaction-induced expression of immediate early gene protein products in the medial prefrontal cortex of male and female rats
Keywords: پرورش جداسازی; Isolation rearing; Prefrontal cortex; Arc; c-Fos; BDNF; Social interaction; Sex differences;
Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity
Keywords: پرورش جداسازی; Schizophrenia; Psychosis; Stress; Mismatch hypothesis; Cumulative stress hypothesis; Maternal care; Maternal separation; Isolation rearing; Prepulse inhibition; Gnawing;
Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats
Keywords: پرورش جداسازی; Anxiety; Isolation rearing; Social interaction; Prefrontal cortex; Female rats; Synaptic marker; Glutamate receptor
Research ReportIsolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats
Keywords: پرورش جداسازی; Aggression; Dopamine; Isolation rearing; Nucleus accumbens; Prefrontal cortex; Serotonin; Social interaction;
Influence of social isolation in the rat on serotonergic function and memory - Relevance to models of schizophrenia and the role  of 5-HT6 receptors
Keywords: پرورش جداسازی; Serotonin; 5-Hydroxytryptamine; Glutamate; Cognition; Learning and memory; Novel object discrimination; Schizophrenia; Isolation rearing; MPEP; 2-methyl-6-(phenylethynyl)-pyridine; CER; conditioned emotional response; PFC; prefrontal cortex; PPI; prepulse
Isolation rearing-induced reduction of brain 5α-reductase expression: Relevance to dopaminergic impairments
Keywords: پرورش جداسازی; 5α-reductase; Isolation rearing; Dopamine; Nucleus accumbens; Medial prefrontal cortex
CRF2 null mutation increases sensitivity to isolation rearing effects on locomotor activity in mice
Keywords: پرورش جداسازی; CRF; CRH; Social isolation; Locomotor activity; Schizophrenia; Isolation rearing; Developmental stress
Developmental emergence of reelin deficits in the prefrontal cortex of Wistar rats reared in social isolation
Keywords: پرورش جداسازی; prepulse inhibition; GABAergic interneurons; isolation rearing; layer I; immunofluorescence; prelimbic cortexANOVA, analysis of variance; BSA, bovine serum albumin; EDTA, ethylenediamine tetra acetic acid; HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfo
Research reportEmotional learning enhances stimulus-specific top-down modulation of sensorimotor gating in socially reared rats but not isolation-reared rats
Keywords: پرورش جداسازی; Fear conditioning; Isolation rearing; Perceptual fusion; Perceived spatial separation; Prepulse inhibition; Schizophrenia; Selective attention;
Chronic fluoxetine differentially modulates the hippocampal microtubular and serotonergic system in grouped and isolation reared rats
Keywords: پرورش جداسازی; Isolation rearing; Fluoxetine; Microtubules; Alpha-tubulin; Neuronal plasticity; Depression
Antidepressant-like effects of the glucocorticoid receptor antagonist RU-43044 are associated with changes in prefrontal dopamine in mouse models of depression
Keywords: پرورش جداسازی; Glucocorticoid receptor antagonist; Antidepressant; Dopamine; Prefrontal cortex; Isolation rearing; Corticosterone
Isolation rearing impairs wound healing and is associated with increased locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile rats
Keywords: پرورش جداسازی; immediate early gene; isolation rearing; wound healing; burn injury; childhood adversity; gene expressionFDR, false discovery rate; GAPDH, glyceraldehyde 3-phophate dehydrogenase; GO, gene ontology; HPA, hypothalamic–pituitary–adrenal; IEG, immediate earl
Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders
Keywords: پرورش جداسازی; Social isolation; Isolation rearing; Schizophrenia; Serotonin; Dopamine; Cognition; Aggression; Prepulse inhibition; Neophobia; Nucleus accumbens; Hippocampus; Frontal cortexDA, dopamine; ED, extra-dimensional; GABA, gamma-amino butyric acid; 5-HT, 5-hydr
Isolation rearing and hyperlocomotion are associated with reduced immediate early gene expression levels in the medial prefrontal cortex
Keywords: پرورش جداسازی; open field; isolation rearing; adolescence; immediate early gene; neuroplasticity; hyperactivity; ADHD; attention deficit hyperactivity disorder; Ap1g1; adaptor-related protein complex 1; Arc; activity related, cytoskeleton-associated; Btg2; B cell transl
Isolation rearing of mice induces deficits in prepulse inhibition of the startle response
Keywords: پرورش جداسازی; Isolation rearing; Prepulse inhibition; Startle; Development; Behavior; Strains; Sensorimotor gating
Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats
Keywords: پرورش جداسازی; Animal model; Atypical antipsychotic; Isolation rearing; Prepulse inhibition; Psychosis; Schizophrenia
Early postnatal isolation reduces dopamine levels, elevates dopamine turnover and specifically disrupts prepulse inhibition in Nurr1-null heterozygous mice
Keywords: پرورش جداسازی; NR4A2; isolation rearing; sensorimotor gating; catecholamine; schizophrenia; ANOVA; analysis of variance; DOPAC; 3,4-dihydroxyphenylacetic acid; +/â; Nurr1-null heterozygous; +/+; Nurr1 wild-type; PPI; prepulse inhibition;
Interaction between isolation rearing and social development on exploratory behavior in male rats
Keywords: پرورش جداسازی; Isolation rearing; Exploratory behavior; Social development; Anxiety; Rats;