Influence of social isolation in the rat on serotonergic function and memory - Relevance to models of schizophrenia and the role  of 5-HT6 receptors

► The isolation reared rat is a preclinical neurodevelopmental model of schizophrenia. ► Isolation causes aberrant hippocampal neuronal plasticity impairing cognition. ► This review examines neural changes accompanying novel object discrimination deficits. ► 5-HT6 antagonists reverse discrimination impairments in isolation reared rats. ► Altered GABA and glutamate function by 5-HT6 antagonists may account for this effect.