دانلود مقالات ISI درباره Mpep + ترجمه فارسی

لوواستاتین باعث کاهش هیجانی و تشنج در مدل سندرم آنجلمن می شود

Lovastatin suppresses hyperexcitability and seizure in Angelman syndrome model

Keywords: AS; Angelman syndrome; BMI; (−)-bicuculline methiodide; DHPG; (RS)-3,5-dihydroxyphenylglycine; EEG; electroencephalogram; FXS; fragile X syndrome; LTD; long-term depression; mGluR; metabotropic glutamate receptor; MPEP; 2-Methyl-6-(phenylethynyl)pyridin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

آسیب پذیری جدی گانگلیوی پایه به محرومیت انرژی: شواهد تجربی و بالینی

Selective basal ganglia vulnerability to energy deprivation: Experimental and clinical evidences

Keywords: 3-HK; 3-hydroxykynurenine; 3-NP; 3-nitropropionic acid; 6−OHDA; 6-hydroxidopamine; AADC; aromatic amino acid decarboxylase; ACA; anterior cerebral artery; ADP; adenosine-5′-diphosphate; ALDH; aldehyde dehydrogenases; ALS; amyotrophic lateral sclerosis

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2018 سفارش ترجمه

اثرات پیش و پس از تزریق گلوتامات در لانه زنبوری قورباغه

Pre- and Postsynaptic Effects of Glutamate in the Frog Labyrinth

Keywords: Glu; l-glutamic acid monosodium salt monohydrate; DMSO; dimethyl sulphoxide; mEPSP; miniature excitatory postsynaptic potential; ICa; calcium current; IKD; delayed potassium current; PKA; protein kinase A; ER; endoplasmic reticulum; LY341495; (2S)-2-amino

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

توسعه نوروپاتولوژی پس از مسمومیت انسانی و اقدامات پزشکی

Development of neuropathology following soman poisoning and medical countermeasures

Keywords: ACh; Acetylcholine; A-P; Anterior-posterior; AChE; Acetylcholinesterase; AD; Alzheimer's disease; Akt; Serine/threonine kinase; ALA; Aplpha linoleic acid; AM; Amygdala; AMPA; α-Amino- 3-hydroxy-5-methyl-4-isoxazolepropionic acid; AP-7; 2-amino-7-phosph

دانلود رایگان متن کامل مقاله ISI 88 صفحه سال انتشار : 2018 سفارش ترجمه

مدولاسیون فارماکولوژیک نوع 5 و 7 گیرنده متولد شده متابوتروپیک گلوتامات، منجر به انقراض ترس اجتماعی در یک زمان وابسته به زمان می شود

Pharmacological modulation of metabotropic glutamate receptor subtype 5 and 7 impairs extinction of social fear in a time-point-dependent manner

Keywords: Social fear conditioning extinction; MPEP; AMN082; mGluR5; mGluR7;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

انتقال های ناشی از نویز و مطالعه توپولوژیک یک سیستم دوره ای استوار است

Noise induced transitions and topological study of a periodically driven system

Keywords: MPEP; Large deviation theory; Lagrangian manifold; Singularities;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

فارماکولوژی پیش از قاعدگی آمفتامین: پیامدهای درمان اختلالات روانپزشکی

Preclinical pharmacology of amphetamine: Implications for the treatment of neuropsychiatric disorders

Keywords: Amphetamine; Endocannabinoids; Glutamate; Monoamines; Endogenous opioids; Pharmacology; 5-HT; serotonin; ACh; acetylcholine; ADHD; attention-deficit/hyperactivity disorder; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDNF; brain-derived n

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

اثرات لیگاند های گیرنده های متابوتروپیک گلوتامات بر رفتار جنس نر در موش صحرایی

Effects of metabotropic glutamate receptor ligands on male sexual behavior in rats

Keywords: mGluR2/3; mGluR5; mGluR7; LY379268; MPEP; AMN082; Sexual behavior;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Distinct Roles of NMDAR and mGluR5 in Light Exposure Reversal of Feedforward Synaptic Strength in V1 of Juvenile Mice after Binocular Vision Deprivation

Keywords: CPP; carboxypiperazin-4-yl-propyl-1-phosphonic acid; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; LTD; long-term depression; LTP; long-term potentiation; MPEP; 2-methyl-6-(phenylethynyl) pyridine hydrochloride; NMDAR; NMDA receptor; visual c

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Renal Function and exposure to Bisphenol A and phthalates in children with Chronic Kidney Disease

Keywords: DEHP; Di (2-ethylhexyl) phthalate; DOP; dioctyl phthalate; HMW; high molecular weight; LMW; low molecular weight; MBP; monobutyl phthalate; MBZP; monobenzyl phthalate; MCHPP; mono-(7-carboxy-n-heptyl) phthalate; MCMHP; mono(2-carboxymethylhexyl) phthalate

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

Endocannabinoid Signaling in Embryonic Neuronal Motility and Cell-Cell Contact - Role of mGluR5 and TRPC3 Channels

Keywords: 2-AG; 2-arachidonoyl glycerol; [Ca2+]i; intracellular free calcium concentration; Afatinib; N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; AM251; 1-(2,4-dichlorophenyl)-5-(4-iodophe

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2018 سفارش ترجمه

Group I metabotropic glutamate receptors generate two types of intrinsic membrane oscillations in hippocampal oriens/alveus interneurons

Keywords: Somatostatin-expressing interneurons; Metabotropic glutamate receptors; Perithreshold membrane oscillations; Excitotoxicity; Seizures; ACPD; 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid; ACSF; artificial cerebrospinal fluid; AMPA; α-Amino-3-hydroxy-5-

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Rescue of Fmr1KO phenotypes with mGluR5 inhibitors: MRZ-8456 versus AFQ-056

Keywords: mGluR5; Fmr1; MRZ-8456; AFQ-056; MPEP; Amyloid-beta precursor protein; Aβ; amyloid-beta; ABC-C; Aberrant Behavior Checklist-Community Edition; AGS; audiogenic-induced seizures; APP; amyloid-beta protein precursor; CNS; central nervous system; CTEP; 2-chl

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson's disease

Keywords: mGlu; Metabotropic glutamate receptor; PD; Parkinson's disease; T10; Triptolide; LPS; lipopolysaccharide; NO; nitric oxide; iNOS; inducible nitric oxide synthase; TNF; tumor necrosis factor; IL; interleukin; SN; substantia nigra; COX; cyclooxygenase; JN

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2018 سفارش ترجمه

Glutamate mGlu5 receptor antagonist, MPEP, reduces the quinpirole-induced compulsive-like checking in rats

Keywords: Obsessive compulsive disorder; Quinpirole; MGluR5; MPEP; Compulsive checking;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Short communicationThe glutamate receptor antagonists CNQX and MPEP decrease fast ripple events in rats treated with kainic acid

Keywords: CNQX; Fast ripples; Hippocampus; Kainic acid; MPEP; Status epilepticus;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Metabotropic glutamate receptor, mGlu5, mediates enhancements of hippocampal long-term potentiation after environmental enrichment in young and old mice

Keywords: Mouse; Murine; Synaptic plasticity; LTD; LTP; in vivo; Environmental enrichment; MPEP; mGlu5;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Metabotropic glutamate receptor 5 mediates the suppressive effect of 6-OHDA-induced model of Parkinson's disease on liver cancer

Keywords: PD; Parkinson's disease; 6-OHDA; 6-hydroxydopamine; mGluR5; metabotropic glutamate receptor 5; TH; tyrosine hydroxylase; MPEP; 2-methyl-6-(phenylethyl)-pyridine; DHPG; (S)-3,5-dihydroxyphenylglycine; CREB; cAMP-response element binding protein; ERK; ext

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

The mGluR5 antagonist MPEP suppresses the expression and reinstatement, but not the acquisition, of the ethanol-conditioned place preference in mice

Keywords: mGluR5; MPEP; Conditioned place preference; Rewarding effects; Mice; Ethanol;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Acute inhibition of mGluR5 disrupts behavioral flexibility

Keywords: mGluR5; metabotropic glutamate receptor 5; MPEP; [2-Methyl-6-(phenylethynyl) pyridine hydrochloride]; PTSD; post-traumatic stress disorder; Extinction; Contextual fear memory; Spatial memory; mGluR5; MPEP; PTSD;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Blockade of metabotropic glutamate receptor 5 protects against DNA damage in a rotenone-induced Parkinson's disease model

Keywords: DHPG; (s)-3,5- dihydroxy-phenylglycine; DMSO; dimethylsulfoxide; ERK; extracellular signal-regulated kinase; MAPK; mitogen-activated protein kinase; mGluR5; metabotropic glutamate receptor 5; MPEP; 2-methyl-6-(phenylethynyl)pyridine; PD; Parkinson's dis

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model

Keywords: Morphine: CID:5288826; MPEP: CID:3025961; Hyperalgesia; Fibrosarcoma; MPEP; Inflammatory pain;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Delayed treatments with pharmacological modulators of pre- and postsynaptic mGlu receptors rescue the hippocampus from kainate-induced neurodegeneration

Keywords: Excitotoxicity; Kainic acid; Hippocampus; MPEP; LY354740; Fluoro-Jade;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat

Keywords: Bortezomib; Neuropathy; Metabotropic glutamate receptor; glutamate reuptake; Hyperalgesia; BINP; Bortezomib induced neuropathy; MPEP; Methyl-6-(phenylethynyl)-pyridine; mGluR5; Metabotropic glutamate receptor 5; SNCV; sensory nerve conduction velocity;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Development of allosteric modulators of GPCRs for treatment of CNS disorders

Keywords: 5MPEP; 5-methyl-6-(phenylethynyl)-pyridine; 6-OHDA; 6-hydroxydopamine; 7TMR; seven transmembrane receptor; 77-LH-28-1; 1-[3-(4-butyl-1-piperidinyl)propyl]-3,4-dihydro-2(1H)-quinolinone; AC-42; 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine; ACh

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2014 سفارش ترجمه

Long-term treatment with l-DOPA and an mGlu5 receptor antagonist prevents changes in brain basal ganglia dopamine receptors, their associated signaling proteins and neuropeptides in parkinsonian monkeys

Keywords: Dopamine receptor; Preproenkephalin; Preprodynorphin; ERK1/2; Akt/GSK3; MPEP;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2014 سفارش ترجمه

Neuropharmacology and analgesiaCapacities of metabotropic glutamate modulators in counteracting soman-induced seizures in rats

Keywords: DCG-IV; HI-6; Levetiracetam; MPEP; Procyclidine; Soman;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

MPEP, an mGlu5 receptor antagonist, reduces the development of l-DOPA-induced motor complications in de novo parkinsonian monkeys: Biochemical correlates

Keywords: mGlu5 receptor; Dyskinesia; l-DOPA; MPTP-lesioned monkey; MPEP;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Is the mGlu5 receptor a possible target for new antidepressant drugs?

Keywords: antidepressant drugs; ketamine; mGlu5 receptor; MTEP; MPEP; NMDA receptor

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats

Keywords: AM251; Amygdala; Bicuculline; Cannabinoid1 (CB1) receptor; MPEP; Pain;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Glutamate receptor dysfunction and drug targets across models of autism spectrum disorders

Keywords: mGluR; Kainate; NMDA; SHANK; Neuroligin; PSD-95; MPEP

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 prevents reinstatement of extinguished ethanol-induced conditioned place preference in mice

Keywords: AMN082; N,N′-Bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride; BEC; blood ethanol concentrations; CPP; conditioned place preference; mGluR; metabotropic glutamate receptor; MMPIP; 6-(4-methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Blockade of metabotropic glutamate receptors inhibits cognition and neurodegeneration in an MPTP-induced Parkinson's disease rat model

Keywords: Parkinson's disease; Dementia; Metabotropic glutamate receptor; MPEP; Cognition;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Orthosteric and allosteric drug binding sites in the Caenorhabditis elegans mgl-2 metabotropic glutamate receptor

Keywords: Allosteric modulator; Calcium-sensing receptor; Family C; MPEP; Pharmacophore; Phylogenetic; Venus flytrap;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Pharmacological interference with metabotropic glutamate receptor subtype 7 but not subtype 5 differentially affects within- and between-session extinction of Pavlovian conditioned fear

Keywords: AMN082; DCS; Fear extinction; L-glutamate; MPEP; mGluR5; mGluR7;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Extracellular cysteine (Cys)/cystine (CySS) redox regulates metabotropic glutamate receptor 5 activity

Keywords: Extracellular cysteine (Cys)/cystine (CySS); Metabotropic glutamate receptor 5; Parkinson's disease; AMS; 4-Acetamide-4′-maleimidylstilbene-2,2′-disulfonic acid, disodium salt; BCA; Bradford Protein Assay; CRD; cysteine-rich domain; Cys; cysteine; C

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Invited reviewMetabotropic glutamate receptors as therapeutic targets for schizophrenia

Keywords: Metabotropic; Glutamate; Schizophrenia; NMDA; allosteric; CNS; central nervous system; DA; dopamine; mGlu; metabotropic glutamate receptor; PAM; positive allosteric modulator; NAM; negative allosteric modulator; MPEP; 2-methyl-6-(phenylethynyl)pyridine; N

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series

Keywords: Glutamate; mGluR5; MPEP; Antagonist

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5

Keywords: mGluR5; MPEP; CDPPB; Allosteric modulators

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Research reportComplex effects of mGluR5 antagonism on sociability and stereotypic behaviors in mice: Possible implications for the pharmacotherapy of autism spectrum disorders

Keywords: Balb/c mice; Autism spectrum disorders; Sociability; Stereotypies; Metabotropic glutamate receptors; NMDA receptor; MPEP;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats

Keywords: Nicotine; Self-administration; Motivation; Food self-administration; Microinjections; VTA; ventral tegmental area; NAcc; nucleus accumbens; MPEP; 2-methyl-6-(phenylethynyl)pyridine; AMPA; amino-3-hydroxy-5-methyl-4-isoxazolepropionate/kainate; NMDA; N-met

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Functional rescue of excitatory synaptic transmission in the developing hippocampus in Fmr1-KO mouse

Keywords: Fragile X syndrome; EPSC; Glutamate; Hippocampus; Development; MPEP

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Influence of social isolation in the rat on serotonergic function and memory - Relevance to models of schizophrenia and the role  of 5-HT6 receptors

Keywords: Serotonin; 5-Hydroxytryptamine; Glutamate; Cognition; Learning and memory; Novel object discrimination; Schizophrenia; Isolation rearing; MPEP; 2-methyl-6-(phenylethynyl)-pyridine; CER; conditioned emotional response; PFC; prefrontal cortex; PPI; prepulse

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Chronic, systemic treatment with a metabotropic glutamate receptor 5 antagonist produces anxiolytic-like effects and reverses abnormal firing activity of projection neurons in the basolateral nucleus of the amygdala in rats with bilateral 6-OHDA lesions

Keywords: Anxiety; Basolateral nucleus of amygdala; MPEP; Parkinson's disease; Extracellular recording;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices

Keywords: Alzheimer’s disease; Amyloid beta; Memantine; Ro 25-6981; MPEP; LTP

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Metabotropic glutamate receptor 5 promotes proliferation of human neural stem/progenitor cells with activation of mitogen-activated protein kinases signaling pathway in vitro

Keywords: neural stem/progenitor cells; proliferation; metabotropic glutamate receptors; mitogen-activated protein kinases; cyclin D1; bFGF; basic fibroblast growth factor; CNS; central nervous system; DHPG; (S)-3,5-dihydroxyphenylglycine hydrate; DMEM/F12; Dulbecc

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Induction of theta-frequency oscillations in the rat medial septal diagonal band slice by metabotropic glutamate receptor agonists

Keywords: metabotropic glutamate receptors; septal region; theta oscillation; ACPD; (1S, 3R)-1-aminocyclopentane-1,3-dicarboxylic acid; ACSF; artificial cerebrospinal fluid; ChAT; choline acetyltransferase; CPCCOEt; 7-(hydroxyimino) cyclopropa[b]chromen-1a-carboxyl

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Lipopolysaccharide-stimulated interleukin-10 release from neonatal spinal cord microglia is potentiated by glutamate

Keywords: inflammation; lipopolysaccharide; microglia; APDC; (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate; BAPTA-AM; 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester); chelerythrine chloride; 1,2-dimethoxy-N-methyl(1,3)benzo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Assessment of GABA-B, metabotropic glutamate, and opioid receptor involvement in an animal model of binge drinking

Keywords: Mice; Alcohol; Operant; Naltrexone; Baclofen; MPEP

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death

Keywords: Amyotrophic lateral sclerosis; Motor neuron; Astrocyte; Excitotoxicity; Metabotropic glutamate receptor 5; MPEP; BDNF;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه