کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8516338 | 1556575 | 2018 | 43 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Group I metabotropic glutamate receptors generate two types of intrinsic membrane oscillations in hippocampal oriens/alveus interneurons
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کلمات کلیدی
HEPES(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acidLY 3673852-aminoethoxydiphenylborateCGP55845SR95531ACPD2-APBMPEPNBQXmGluRAPVN-methyl-d-aspartateDHPGDICFFAAMPAaCSFNMDATTX(S)-3,5-dihydroxyphenylglycine - (S) -3،5-دی هیدروکسی فنیل گلیسین1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid - 1،2-bis (2-aminophenoxy) ethane-N، N، N '، N'-tetraacetic acid2-methyl-6-(phenylethynyl)pyridine hydrochloride - 2- متیل-6- (فنیل اتیینیل) پیریدین هیدروکلراید2-amino-5-phosphonopentanoic acid - 2-آمینو-5-فسفونوپنتانوئیک اسید4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid - 4- (2-hydroxyethyl) -1-piperazineethanesulfonic acidα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid - اسید α-آمینو 3-هیدروکسی-5-متیل-4-ایزوکسول پپونیکflufenamic acid - اسید فلوفنامیکexcitotoxicity - اکسید سمیتBAPTA - بیایپیتیایtetrodotoxin - تترو دوتوکسین Seizures - تشنجartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیaction potential - پتانسیل عمل TRP channels - کانال های TRPdifferential interference contrast - کنتراست تداخل دیفرانسیلMetabotropic glutamate receptors - گیرنده های متابوتروپیک گلوتاماتMetabotropic glutamate receptor - گیرنده گلوتامات متابوتروپیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Group I metabotropic glutamate receptors generate two types of intrinsic membrane oscillations in hippocampal oriens/alveus interneurons Group I metabotropic glutamate receptors generate two types of intrinsic membrane oscillations in hippocampal oriens/alveus interneurons](/preview/png/8516338.png)
چکیده انگلیسی
GABAergic interneurons in the hippocampus are critically involved in almost all hippocampal circuit functions including coordinated network activity. Somatostatin-expressing oriens-lacunosum moleculare (O-LM) interneurons are a major subtype of dendritically projecting interneurons in hippocampal subregions (e.g., CA1), and express group I metabotropic glutamate receptors (mGluRs), specifically mGluR1 and mGluR5. Group I mGluRs are thought to regulate hippocampal circuit functions partially through GABAergic interneurons. Previous studies suggest that a group I/II mGluR agonist produces slow supra-threshold membrane oscillations (<0.1â¯Hz), which are associated with high-frequency action potential (AP) discharges in O-LM interneurons. However, the properties and underlying mechanisms of these slow oscillations remain largely unknown. We performed whole-cell patch-clamp recordings from mouse interneurons in the stratum oriens/alveus (O/A interneurons) including CA1 O-LM interneurons. Our study revealed that the selective mGluR1/5 agonist (S)-3,5-dihydroxyphenylglycine (DHPG) induced slow membrane oscillations (<0.1â¯Hz), which were associated with gamma frequency APs followed by AP-free perithreshold gamma oscillations. The selective mGluR1 antagonist (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid (LY367385) reduced the slow oscillations, and the selective mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine hydrochloride (MPEP) partially blocked them. Blockade of nonselective cation-conducting transient receptor potential channels, L-type Ca2+ channels, or ryanodine receptors all abolished the slow oscillations, suggesting the involvement of multiple mechanisms. Our findings suggest that group I mGluR activation in O/A interneurons may play an important role in coordinated network activity, and O/A interneuron vulnerability to excitotoxicity, in disease states like seizures, is at least in part due to an excessive rise in intracellular Ca2+.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 139, 1 September 2018, Pages 150-162
Journal: Neuropharmacology - Volume 139, 1 September 2018, Pages 150-162
نویسندگان
Gubbi Govindaiah, Young-Jin Kang, Hannah Elisabeth Smashey Lewis, Leeyup Chung, Ethan M. Clement, Lazar John Jr., Edgar Garcia-Rill, Sang-Hun Lee,