Pharmacological interference with metabotropic glutamate receptor subtype 7 but not subtype 5 differentially affects within- and between-session extinction of Pavlovian conditioned fear

► We examined mGluR5 and -7 drugs on extinction of Pavlovian conditioned fear. ► mGluR5 blockade with MPEP had no effect on extinction of fear. ► The mGluR7 activator AMN082 inhibited within-session fear extinction. ► AMN082-, but not MPEP-treated rats showed facilitated between-session extinction. ► Our results suggest discrete clinical application modes for mGluR7 drugs.