Keywords: Anxiety; Bipolar disorder; Major depressive disorder; Metabotrobic glutamatergic receptor subtype 5; mGluR5; Positron emission tomography;
مقالات ISI (ترجمه نشده)
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Keywords: Arc/Arg3.1; Dynamin; mGluR5; Long-term synaptic depression; Synapse elimination;
Keywords: Aβ; amyloid Beta; AQP; aquaporin; AD; Alzheimer's disease; CNS; central nervous system; Cx; connexin; DS; Down syndrome; GJ; gap junction; GFAP; glial fibrillary acidic protein; GS; glutamine synthetase; HS; hippocampal sclerosis; IP3R2; inositol triph
Keywords: Transcranial electrical stimulation; tDCS; tACS; tRNS; Neuromodulation; Animal models; AC; alternating current; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDNF; brain-derived neurotrophic factor; DC; direct current; EEG; electroencephalo
Keywords: AA; amino acid; Aβo; oligomeric β-amyloid; Aβ; β-amyloid; AD; Alzheimer's disease; α7nAChR; α7 nicotinic acetylcholine receptor; ALS; amyotrophic lateral sclerosis; APLP1; amyloid beta precursor-like protein 1; APP; amyloid precursor protein; β-A
Keywords: Social fear conditioning extinction; MPEP; AMN082; mGluR5; mGluR7;
Keywords: Schizophrenia; Glutamate; Nicotine; mGluR5; Positron emission tomography;
Keywords: P2Â ÃÂ 7; purinergic receptor P2Â ÃÂ 7; mGluR5; metabotropic glutamate receptor 5; DAT; dopamine transporter; AQP4; aquaporin-4; DOPE; 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; GLT-1; glutamate transporter-1; Cav1.2; L-type voltage-gated calcium ch
Keywords: [18F]FPEB; Glutamate; 1H MRS; MDD; mGluR5; PET;
Keywords: Cannabinoid; Endocannabinoid; Pain; FAAH; MAGL; Stress; Stress-induced analgesia; Stress-induced hyperalgesia; mGluR5; mPFC; Amygdala; Cortical control of pain; AA-5-HT (PubChem CID: 10027372); BIA-102474 (PubChem CID: 46831476); JZL184 (PubChem CID: 2502
Keywords: Pain; Amygdala; ERK1/2; mGluR5;
Keywords: Abstinence; Addiction; Glutamate; mGluR5; Nicotine; Relapse;
Keywords: CNS; central nervous system; CRH; corticotropin releasing hormone; CRHR1; corticotropin releasing hormone receptor type 1; irCRH; immune-reactive CRH; PET; positron emission tomography; SPECT; single photon tomography; fMRI; functional magnetic resonance
Keywords: CHPG; (RS)-2-chloro-5-hydroxyphenylglycine; FRET; fluorescence resonance energy transfer; LPS; lipopolysaccharide; mGluR5; Group I metabotropic glutamate receptor 5; MTEP; 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine; NF-κB; nuclear factor-kappa B; PAM
Keywords: Amphetamine; Endocannabinoids; Glutamate; Monoamines; Endogenous opioids; Pharmacology; 5-HT; serotonin; ACh; acetylcholine; ADHD; attention-deficit/hyperactivity disorder; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDNF; brain-derived n
Keywords: Essential tremor; Brain; Genetics; Human population; Mouse models; Pathophysiology; ABA; Allen brain atlas; AβPPswe/PS1ÎE9; amyloid-β protein precursor and presenilin-1; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ATP; adenosine tri-ph
Keywords: mGluR2/3; mGluR5; mGluR7; LY379268; MPEP; AMN082; Sexual behavior;
Keywords: mGluR5; mGlu5; Metabotropic glutamate receptor 5; Schizophrenia; NMDA receptor; Positive allosteric modulator; PAM; Antipsychotic;
Keywords: mGluR5; Negative allosteric modulator; Hit to lead studies; CNS drug discovery
Keywords: mGluR5; Negative allosteric modulator; 4-Aryl-3-arylsulfonyl-quinolines
Neurogranin in the nucleus accumbens regulates NMDA receptor tolerance and motivation for ethanol seeking
Keywords: Ethanol; Neurogranin; Operant conditioning; Glutamate receptors; Nucleus accumbens; Motivation; NMDAR; of N-methyl-d-aspartate receptors; Ng; Neurogranin; AUD; alcohol use disorders; mGluR5; metabotropic glutamate receptor 5; NAc; nucleus accumbens; AAV;
mGluR5 upregulation and the effects of repeated methamphetamine administration and withdrawal on the rewarding efficacy of ketamine and social interaction
Keywords: Ketamine; Methamphetamine; Superfusion; Dopamine; mGluR5;
PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease
Keywords: Alzheimer's disease; Mouse model; Non-receptor tyrosine protein kinase; Pyk2; Src; 5XFAD; mice transgenic for human APP and presenilin1 with 5 mutations found in familial Alzheimer's disease; AAV; adeno-associated virus; Aβ; amyloid β; AD; Alzheimer's d
Effects of short- and long-term aripiprazole treatment on Group I mGluRs in the nucleus accumbens: Comparison with haloperidol
Keywords: mGluR1; mGluR5; Norbin; Homer1a; Homer1b/c; Ventral striatum; Antipsychotic;
Impact of Thalamocortical Input on Barrel Cortex Development
Keywords: AC1; adenylyl cyclase 1; CTAs; corticothalamic axons; ION; infraorbital nerve injury; mGluR5; metabotropic glutamate receptor 5; PSPB; pallial-subpallial boundary; RIM; Rab3 interacting molecules; TCAs; thalamocortical axons; VPM; ventro-posteromedial nuc
The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?
Keywords: 13C MRS; carbon-13 magnetic resonance spectroscopy; ABP; aminoacid-based pathology; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; BDNF; brain derived neurotrophic factor; BOLD; blood oxygen level dependent; CSP; chronic stress pat
Aβ pathology downregulates brain mGluR5 density in a mouse model of Alzheimer
Keywords: Alzheimer's disease; 5xFAD mice; [18F]FPEB; β-Amyloid; mGluR5; PET;
Endocannabinoid Signaling in Embryonic Neuronal Motility and Cell-Cell Contact - Role of mGluR5 and TRPC3 Channels
Keywords: 2-AG; 2-arachidonoyl glycerol; [Ca2+]i; intracellular free calcium concentration; Afatinib; N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; AM251; 1-(2,4-dichlorophenyl)-5-(4-iodophe
Rescue of Fmr1KO phenotypes with mGluR5 inhibitors: MRZ-8456 versus AFQ-056
Keywords: mGluR5; Fmr1; MRZ-8456; AFQ-056; MPEP; Amyloid-beta precursor protein; Aβ; amyloid-beta; ABC-C; Aberrant Behavior Checklist-Community Edition; AGS; audiogenic-induced seizures; APP; amyloid-beta protein precursor; CNS; central nervous system; CTEP; 2-chl
Synthesis and optimization of 4,5,6,7-tetrahydrooxazolo[4,5-c]pyridines as potent and orally-active metabotropic glutamate receptor 5 negative allosteric modulators
Keywords: mGluR5; Negative allosteric modulator; CNS drug discovery; Anti-depressant agent;
Glutamate mGlu5 receptor antagonist, MPEP, reduces the quinpirole-induced compulsive-like checking in rats
Keywords: Obsessive compulsive disorder; Quinpirole; MGluR5; MPEP; Compulsive checking;
Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [11C]ABP688 PET imaging and ex vivo immunoblotting
Keywords: PET; Alzheimer's disease; mGluR5; [11C]ABP688;
Research articleActivated mGluR5 protects BV2 cells against OGD/R induced cytotoxicity by modulating BDNF-TrkB pathway
Keywords: mGluR5; OGD/R; BV2 cells; BDNF/TrkB pathway;
Structural and molecular determinants regulating mGluR5 surface expression
Keywords: GPCR; mGluR5; Truncation; Membrane trafficking; Dimerization; Ligand binding; Metabotropic glutamate receptor;
Metabotropic glutamate receptor 5 mediates the suppressive effect of 6-OHDA-induced model of Parkinson's disease on liver cancer
Keywords: PD; Parkinson's disease; 6-OHDA; 6-hydroxydopamine; mGluR5; metabotropic glutamate receptor 5; TH; tyrosine hydroxylase; MPEP; 2-methyl-6-(phenylethyl)-pyridine; DHPG; (S)-3,5-dihydroxyphenylglycine; CREB; cAMP-response element binding protein; ERK; ext
Shifting towards a model of mGluR5 dysregulation in schizophrenia: Consequences for future schizophrenia treatment
Keywords: Metabotropic glutamate receptor 5; mGluR5; Protein regulation; Glutamate; Schizophrenia; Novel therapy; 7TMD; 7-transmembrane domain; BA; Brodmann Area; BDNF; brain-derived neurotrophic factor; CA; Cornu ammonis; Ca2+; Calcium ions; Calcineurin/PPB2; prot
Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box
Keywords: mGluR5; mGlu5; Positive allosteric modulator; Silent allosteric modulator; Schizophrenia; Cognition;
Computer-aided design of negative allosteric modulators of metabotropic glutamate receptor 5 (mGluR5): Comparative molecular field analysis of aryl ether derivatives
Keywords: mGluR5; Negative allosteric modulators; Aryl ethers; CoMFA; 3-D QSAR
Difluorocyclobutylacetylenes as positive allosteric modulators of mGluR5 with reduced bioactivation potential
Keywords: mGluR5; PAMs; Cognition; Schizophrenia; Bioactivation;
Acute inhibition of mGluR5 disrupts behavioral flexibility
Keywords: mGluR5; metabotropic glutamate receptor 5; MPEP; [2-Methyl-6-(phenylethynyl) pyridine hydrochloride]; PTSD; post-traumatic stress disorder; Extinction; Contextual fear memory; Spatial memory; mGluR5; MPEP; PTSD;
The mGluR5 antagonist MPEP suppresses the expression and reinstatement, but not the acquisition, of the ethanol-conditioned place preference in mice
Keywords: mGluR5; MPEP; Conditioned place preference; Rewarding effects; Mice; Ethanol;
Metabotropic Glutamate Receptor and Fragile X Signaling in a Female Model of Escalated Aggression
Keywords: Aggression; Fragile X; mGluR5; Nucleus accumbens; Plasticity; PSD-95;
The anti-absence effect of mGlu5 receptor amplification with VU0360172 is maintained during and after antiepileptogenesis
Keywords: Antiepileptogenesis; mGluR5; Electroencephalography; Genetic absence epilepsy model; WAG/Rij rats; Ethosuximide; Western blots; Y-maze learning
Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice
Keywords: Circuit; Constitutive activity; mGluR5; Obsessive-compulsive disorder; Positive allosteric modulator; Striatum;
Repeated low-dose kainate administration in C57BL/6J mice produces temporal lobe epilepsy pathology but infrequent spontaneous seizures
Keywords: Temporal lobe epilepsy; Seizure; C57 (C57BL/6J); Kainate; Valproic acid; Astrogliosis; mGluR5; Cell death; Neurodegeneration;
Astrocytes in physiological aging and Alzheimer's disease
Keywords: 3xTg-AD; triple transgenic mice model of Alzheimer's disease; AD; Alzheimer's disease; APP; amyloid precursor protein; ATP; adenosine triphosphate; CA1; Cornu Ammonis 1; CNS; Central nervous system; DG; dentate gyrus; GABA; γ-aminobutyric acid; GFAP;
Convergent evidence for mGluR5 in synaptic and neuroinflammatory pathways implicated in ASD
Keywords: mGluR5; Glutamate; Autism spectrum disorder; Neurodevelopment; GRM5; Neuroinflammation; Microglia;
Combined behavioral studies and in vivo imaging of inflammatory response and expression of mGlu5 receptors in schnurri-2 knockout mice
Keywords: Schnurri-2 (Shn-2) knockout (KO) mice; PET; mGluR5; Inflammation; Schizophrenia;
Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Lead optimization
Keywords: mGluR5; Negative allosteric modulator; Thieno[2,3-b]pyridines
The selective mGluR5 agonist CHPG attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells
Keywords: SO2; Microglia; Inflammation; mGluR5; TSG-6; NF-κB