Metabotropic glutamate receptor 5 in the pathology and treatment of schizophrenia

► mGluR5 is of interest as a novel therapeutic target for schizophrenia. ► mGluR5 potentiates the NMDAR in brain regions implicated in schizophrenia. ► We review data that supports and refutes the involvement of mGluR5 in schizophrenia. ► We discuss the potential of mGluR5 modulators in the therapy of schizophrenia.