دانلود مقالات ISI درباره Mglur5 + ترجمه فارسی

The identification of novel orally active mGluR5 antagonist GSK2210875

Keywords: mGluR; mGluR5; Brain free fraction; Negative allosteric modulator; Allosteric modulator; GPCR; Family C GPCR; Metabotropic glutamate receptor

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

4-Aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators

Keywords: mGluR5; Positive allosteric modulator; Schizophrenia

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs

Keywords: mGluR5; Negative allosteric modulator; Parallel synthesis;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

NMDA but not AMPA glutamatergic receptors are involved in the antidepressant-like activity of MTEP during the forced swim test in mice

Keywords: mGluR5; MTEP; forced swim test; NMDA; AMPA; ligands;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Protective effect of metabotropic glutamate mGluR5 receptor elimination in a 6-hydroxydopamine model of Parkinson's disease

Keywords: Neuroprotection; mGluR5; Dopamine level; Behavioral tests; Parkinson's disease

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Effect of the metabotropic glutamate receptor type 5 antagonists MPEP and MTEP in parkinsonian monkeys

Keywords: mGluR5; Dyskinesia; Levodopa; MPTP monkey; MPEP; MTEP;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Effects of a positive allosteric modulator of mGluR5 ADX47273 on conditioned avoidance response and PCP-induced hyperlocomotion in the rat as models for schizophrenia

Keywords: Locomotor activity; Catalepsy; CAR; Phencyclidine; ADX47273; Olanzapine; Aripiprazole; Haloperidol; mGluR5

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Nicotine-induced conditioned place preference in rats: Sex differences and the role of mGluR5 receptors

Keywords: Nicotine; Acetylcholine; Conditioned place preference; Sex differences; mGluR5; MPEP

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Regulation of group I metabotropic glutamate receptor expression in the rat striatum and prefrontal cortex in response to amphetamine in vivo

Keywords: mGluR1; mGluR5; Dopamine; Stimulant; Cortex; Caudate; Nucleus accumbens; Addiction; Reward

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Differential distribution of group I metabotropic glutamate receptors in developing human cortex

Keywords: Metabotropic glutamate receptor; Human cortex; Cortical development; Immunocytochemistry; mGluR1; mGluR5

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Structure–activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5

Keywords: mGluR, metabotropic glutamate receptor; iGluR, ionotropic glutamate receptor; MPEP, 2-methyl-6-(phenylethynyl)pyridine; MTEP, 3-((2-methyl-4-thiazolyl)ethynyl)pyridineMetabotropic glutamate receptor subtype 5; mGluR5; MPEP; MTEP; Drug abuse

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Metabotropic Glutamate Receptor 5 Activity in the Nucleus Accumbens Is Required for the Maintenance of Ethanol Self-Administration in a Rat Genetic Model of High Alcohol Intake

Keywords: Alcohol drinking; alcoholism; caudate; LY379268; mGluR2/3; mGluR5; MPEP; nucleus accumbens; P-rats; prefrontal cortex; reinforcement; self-administration

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Metabotropic glutamate receptors 1 and 5 differentially regulate bulbar dopaminergic cell function

Keywords: Olfactory bulb; Dopaminergic neuron; Glutamate; mGluR; mGluR5; Patch-clampt-ACPD, 1-aminocyclopentane-trans-1,3-dicarboxylic acid; AP5, d-2-amino-5-phosphonopentanoic acid; BAPTA, 1,2-bis-(2-aminophenoxy)-N,N,N′,N′-tetra acetic acid; BMI, bicuculline meth

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2010 سفارش ترجمه

Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator

Keywords: mGluR5; Glutamate; Allosteric; Positive allosteric modulator; Rat; Mouse

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Positive Allosteric Modulation of mGluR5 Receptors Facilitates Extinction of a Cocaine Contextual Memory

Keywords: Cocaine; conditioned place preference; contextual memory; extinction learning; mGluR5

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype

Keywords: mGluR5; Metabotropic; Glutamate

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS

Keywords: mGluR5; Negative allosteric modulator; Positive allosteric modulator

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Expression of Metabotropic Glutamate Receptor mGluR5 in Human Dental Pulp

Keywords: Immunocytochemistry; mGluR5; nociception; tooth pulp; TRPV1

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Inhibitory effects of Group I metabotropic glutamate receptors antagonists on the expression of NMDA receptor NR1 subunit in morphine tolerant rats

Keywords: CNS; central nervous system; iGluRs; ionotropic glutamate receptors; NMDAR; N-methyl-d-aspartic acid receptor; NR1; NMDA-R1 subunit; mGluRs; metabotropic glutamate receptors; mGluR1; mGlu receptor subtype 1; mGluR5; mGlu receptor subtype 5; AIDA; (RS)-1-A

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Synaptic receptor trafficking: The lateral point of view

Keywords: synapse; receptor; diffusion; FRAP; single particle tracking; ANQX; 6-azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione; FCS; fluorescence correlation spectroscopy; FRAP; fluorescence recovery after photobleaching; GFP; green fluorescent protein; mGFP; membr

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking

Keywords: Relapse; Addiction; Psychostimulant; Glutamate; Metabotropic; mGluR5; MPEP; MTEP

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Astrocytic control of synaptic transmission and plasticity: a target for drugs of abuse?

Keywords: Astrocyte; Glia; mGluR5; CB-1; GABAB; Cocaine; Gliotransmission; Tripartite synapse; Synaptic plasticity

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Modification upon aging of the density of presynaptic modulation systems in the hippocampus

Keywords: Aging; Nerve terminals; Density; Adenosine; A1; A2A; CB1; P2Y1; Metabotropic; Glutamate; MGluR5; GABA; Acetylcholine; Synaptophysin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

CB1 receptor knockout mice are hyporesponsive to the behavior-stimulating actions of d-amphetamine: Role of mGlu5 receptors

Keywords: CB1 receptor; mGluR5; d-amphetamine; MK-801; Locomotor activity; Dopamine; Microdialysis

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Age-dependent anticonvulsant action of antagonists of group I glutamate metabotropic receptors in rats

Keywords: Rat; Ontogeny; Pentetrazol; Convulsions; mGluR5; mGluR1

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Locomotor sensitization to cocaine is associated with distinct pattern of glutamate receptor trafficking to the postsynaptic density in prefrontal cortex: Early versus late withdrawal effects

Keywords: AMPA; NMDA; mGluR5; Addiction; Scaffolding proteins; Synaptic plasticity; Prefrontal cortex; Anterior cingulate cortex; Cocaine; Locomotor sensitization; Postsynaptic density

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Dopamine D1 receptor-dependent modifications in the dopamine and cAMP-regulated phosphoprotein of Mr 32 kDa phosphorylation pattern in striatal areas of morphine-sensitized rats

Keywords: caudate putamen; nucleus accumbens; metabotropic glutamate receptor 5; MGluR5; μ-opioid receptor; unavoidable stressANOVA, analysis of variance; CPu, caudate-putamen; DARPP-32, dopamine and cAMP-regulated phosphoprotein of Mr 32 kDa; mGluR5, metabotropic

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2009 سفارش ترجمه

Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: Unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold

Keywords: Allosteric; mGluR5; Partial antagonism; Positive allosteric modulation; Antagonist

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Involvement of group I mGluRs in LTP induced by strong high frequency stimulation in the dentate gyrus in vitro

Keywords: LTP; mGluR5; Ryanodine; Dentate gyrus

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Phenylethynyl-pyrrolo[1,2-a]pyrazine: A new potent and selective tool in the mGluR5 antagonists arena

Keywords: mGluR5; Metabotropic; 7-TM; Receptor; Antagonists

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Increased glutamate receptor gene expression in the cerebral cortex of insulin induced hypoglycemic and streptozotocin-induced diabetic rats

Keywords: hypoglycemia; glutamate excitotoxicity; cerebral cortex; NMDA2B; mGluR5; ANOVA; analysis of variance; Bmax; maximal binding; CT; threshold cycle; IIH; insulin-induced hypoglycemia; Kd; equilibrium dissociation constant; mGluR; metabotropic glutamate recep

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Duration of ultrasonic vocalizations in the isolated rat pup as a behavioral measure: Sensitivity to anxiolytic and antidepressant drugs

Keywords: Anxiety; USV; Benzodiazepine; Depression; mGluR5; 5HT1A; SSRI; Tricylic

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Effects of subtype-selective group I mGluR antagonists on synchronous activity induced by 4-aminopyridine/CGP 55845 in adult guinea pig hippocampal slices

Keywords: GABA; mGluR1; mGluR5; Metabotropic glutamate receptor; Electrophysiology

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: Blockade by the mGluR5 antagonist MPEP

Keywords: Alcoholism; Alcohol reinforcement; Relapse; Cue-induced reinstatement; ERK/MAPK; ERK1/2; mGluR5; MPEP; Alcohol-preferring P-rats

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Involvement of metabotropic glutamate 5 receptor in visceral pain

Keywords: Colorectal distension; Visceral pain; Visceromotor response; Colonic afferents; mGluR5; Glutamate

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

mGluR5 metabotropic glutamate receptors and dyskinesias in MPTP monkeys

Keywords: Basal ganglia; Parkinson's disease; Dyskinesias; mGluR5; NMDA antagonist; Cabergoline

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the nucleus accumbens of cocaine-treated rats

Keywords: immunogold; mGluR1a; mGluR5; nucleus accumbens; cocaine; DHPGDAB, 3,3′-diaminobenzidine tetrahydrochloride; DHPG, (RS)-3,5-dihydroxyphenylglycine; GPCR, G-protein-coupled receptor; LTD, long-term depression; mGluR, metabotropic glutamate receptor; NGS, no

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

Receptor-receptor interactions within receptor mosaics. Impact on neuropsychopharmacology

Keywords: Heteromerization; Striatum; Dopamine receptor; CB1 receptor; Adenosine receptor; mGluR5; 5-HT1A receptor; Galanin receptor; Parkinson's disease; Schizophrenia; Drug addiction; Depression; Treatment strategy;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2008 سفارش ترجمه

Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists

Keywords: mGluR5; Antagonist; MPEP

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

Rational design, synthesis, and structure–activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure

Keywords: mGluR5; Fenobam; Anxiety; MPEP; Benzoxazolone

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists

Keywords: mGluR5; Fenobam; Anxiety; MPEP; Pharmacophore

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Challenges in the development of mGluR5 positive allosteric modulators: The discovery of CPPHA

Keywords: MGluR5; Allosteric modulator; Potentiation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Induction of astrogliosis by activated microglia is associated with a down-regulation of metabotropic glutamate receptor 5

Keywords: Microglia; Reactive astrocytes; Neuroinflammation; Cytokines; mGluR5

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Radiolabeling and in vitro and in vivo evaluation of [18F]-FE-DABP688 as a PET radioligand for the metabotropic glutamate receptor subtype 5

Keywords: mGluR5; quad-HIDAC; Small-animal PET imaging; [18F]-FE-DABP688

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Species differences in mGluR5 binding sites in mammalian central nervous system determined using in vitro binding with [18F]F-PEB

Keywords: mGluR5; Radioligand binding; CNS; Species differences

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Phenyl ureas of creatinine as mGluR5 antagonists. A structure–activity relationship study of fenobam analogues

Keywords: Fenobam; Metabotropic glutamate receptor; mGluR5; Anxiolytic

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2006 سفارش ترجمه

Involvement of mGluR5 in the ethanol-induced neuropathic pain-like state in the rat

Keywords: Ethanol; Neuropathy; mGluR5; Spinal cord;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists

Keywords: Metabotropic glutamate receptor subtype 5; mGluR5; Noncompetitive antagonists

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists

Keywords: mGluR5; Metabotropic glutamate receptor; Anxiolytic; Anxiolysis

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

The role of group I metabotropic glutamate receptors in memory consolidation and reconsolidation in the passive avoidance task in 1-day-old chicks

Keywords: Metabotropic glutamate receptors; mGluR5; Memory reconsolidation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه