کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4341038 1295821 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synaptic receptor trafficking: The lateral point of view
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Synaptic receptor trafficking: The lateral point of view
چکیده انگلیسی
Activity dependent modification of receptors in the post-synaptic density is a key determinant in regulating the strength of synaptic transmission during development and plasticity. A major mechanism for this recruitment and removal of postsynaptic proteins is the lateral diffusion in the plane of the plasma membrane. Therefore, the processes that regulate this lateral mobility are of fundamental importance. In recent years significant progress has been achieved using optical approaches such as single particle tracking (SPT) and fluorescence recovery after photobleach (FRAP). Here, we provide an overview of the principles and methodology of these techniques and highlight the contributions they have made to current understanding of protein mobility in the plasma membrane.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 158, Issue 1, 12 January 2009, Pages 19-24
نویسندگان
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